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Article: Is subchondral bone cyst formation in non-load-bearing region of osteoarthritic knee a vascular problem?

TitleIs subchondral bone cyst formation in non-load-bearing region of osteoarthritic knee a vascular problem?
Authors
Issue Date2017
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/mehy
Citation
Medical Hypotheses, 2017, v. 109, p. 80-83 How to Cite?
AbstractSubchondral bone cyst is common in the progressive knee osteoarthritis yet its underlying mechanism remains unclear. In addition to the existing theories such as synovial fluid influx and mechanical contusion, we identified the potential link between vascular pathology and osteoarthritic bone pathologies including cystic lesion formation, particularly in the non-load-bearing region. This new hypothesis for SBC formation in non-load-bearing region for knee, which cannot be explained by the existing theories, will provide us a new angle to understand the pathomechanism and pathophysiology of subchondral bone disturbance in osteoarthritis in addition to the classical biomechanical overloading theories. It might guide us to develop a novel diagnostic and therapeutic approach to treat progressive osteoarthritis via targeting vascular pathology.
Persistent Identifierhttp://hdl.handle.net/10722/260548
ISSN
2019 Impact Factor: 1.375
2015 SCImago Journal Rankings: 0.464
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, PMB-
dc.contributor.authorWen, C-
dc.contributor.authorYang, WC-
dc.contributor.authorYan, CH-
dc.contributor.authorChiu, PKY-
dc.date.accessioned2018-09-14T08:43:32Z-
dc.date.available2018-09-14T08:43:32Z-
dc.date.issued2017-
dc.identifier.citationMedical Hypotheses, 2017, v. 109, p. 80-83-
dc.identifier.issn0306-9877-
dc.identifier.urihttp://hdl.handle.net/10722/260548-
dc.description.abstractSubchondral bone cyst is common in the progressive knee osteoarthritis yet its underlying mechanism remains unclear. In addition to the existing theories such as synovial fluid influx and mechanical contusion, we identified the potential link between vascular pathology and osteoarthritic bone pathologies including cystic lesion formation, particularly in the non-load-bearing region. This new hypothesis for SBC formation in non-load-bearing region for knee, which cannot be explained by the existing theories, will provide us a new angle to understand the pathomechanism and pathophysiology of subchondral bone disturbance in osteoarthritis in addition to the classical biomechanical overloading theories. It might guide us to develop a novel diagnostic and therapeutic approach to treat progressive osteoarthritis via targeting vascular pathology.-
dc.languageeng-
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/mehy-
dc.relation.ispartofMedical Hypotheses-
dc.titleIs subchondral bone cyst formation in non-load-bearing region of osteoarthritic knee a vascular problem?-
dc.typeArticle-
dc.identifier.emailYan, CH: yanchoi@hku.hk-
dc.identifier.emailChiu, PKY: pkychiu@hkucc.hku.hk-
dc.identifier.authorityYan, CH=rp00303-
dc.identifier.authorityChiu, PKY=rp00379-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.mehy.2017.09.027-
dc.identifier.pmid29150301-
dc.identifier.scopuseid_2-s2.0-85030327822-
dc.identifier.hkuros291573-
dc.identifier.volume109-
dc.identifier.spage80-
dc.identifier.epage83-
dc.identifier.isiWOS:000418221200018-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0306-9877-

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