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Article: Nanoscale imaging and force probing of biomolecular systems using atomic force microscopy: from single molecules to living cells

TitleNanoscale imaging and force probing of biomolecular systems using atomic force microscopy: from single molecules to living cells
Authors
Issue Date2017
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/journals/journalissues/nr#!recentarticles&all
Citation
Nanoscale, 2017, v. 9, p. 17643-17666 How to Cite?
AbstractDue to the lack of adequate tools for observation, native molecular behaviors at the nanoscale have been poorly understood. The advent of atomic force microscopy (AFM) provides an exciting instrument for investigating physiological processes on individual living cells with molecular resolution, which attracts the attention of worldwide researchers. In the past few decades, AFM has been widely utilized to investigate molecular activities on diverse biological interfaces, and the performances and functions of AFM have also been continuously improved, greatly improving our understanding of the behaviors of single molecules in action and demonstrating the important role of AFM in addressing biological issues with unprecedented spatiotemporal resolution. In this article, we review the related techniques and recent progress about applying AFM to characterize biomolecular systems in situ from single molecules to living cells. The challenges and future directions are also discussed.
Persistent Identifierhttp://hdl.handle.net/10722/262332

 

DC FieldValueLanguage
dc.contributor.authorLi, M-
dc.contributor.authorDang, D-
dc.contributor.authorXi, N-
dc.contributor.authorWang, Y-
dc.contributor.authorLiu, L-
dc.date.accessioned2018-09-28T04:57:30Z-
dc.date.available2018-09-28T04:57:30Z-
dc.date.issued2017-
dc.identifier.citationNanoscale, 2017, v. 9, p. 17643-17666-
dc.identifier.urihttp://hdl.handle.net/10722/262332-
dc.description.abstractDue to the lack of adequate tools for observation, native molecular behaviors at the nanoscale have been poorly understood. The advent of atomic force microscopy (AFM) provides an exciting instrument for investigating physiological processes on individual living cells with molecular resolution, which attracts the attention of worldwide researchers. In the past few decades, AFM has been widely utilized to investigate molecular activities on diverse biological interfaces, and the performances and functions of AFM have also been continuously improved, greatly improving our understanding of the behaviors of single molecules in action and demonstrating the important role of AFM in addressing biological issues with unprecedented spatiotemporal resolution. In this article, we review the related techniques and recent progress about applying AFM to characterize biomolecular systems in situ from single molecules to living cells. The challenges and future directions are also discussed.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/journals/journalissues/nr#!recentarticles&all-
dc.relation.ispartofNanoscale-
dc.titleNanoscale imaging and force probing of biomolecular systems using atomic force microscopy: from single molecules to living cells-
dc.typeArticle-
dc.identifier.emailXi, N: xining@hku.hk-
dc.identifier.authorityXi, N=rp02044-
dc.identifier.doi10.1039/C7NR07023C-
dc.identifier.hkuros292802-
dc.identifier.volume9-
dc.identifier.spage17643-
dc.identifier.epage17666-

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