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Article: Neuraminidase inhibitor susceptibility and evolutionary analysis of human influenza B isolates from three Asian countries during 2012–2015

TitleNeuraminidase inhibitor susceptibility and evolutionary analysis of human influenza B isolates from three Asian countries during 2012–2015
Authors
Issue Date2018
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/meegid
Citation
Infection, Genetics and Evolution, 2018, v. 62, p. 27-33 How to Cite?
AbstractInfluenza B viruses of both the Yamagata and the Victoria lineages are implicated in a large proportion of the morbidity and mortality associated with influenza outbreaks. In this study, we characterized the full genomes of 53 influenza B viruses isolated during 2012-2015 in three Asian countries: Japan, Myanmar, and Vietnam. Analysis of the hemagglutinin (HA) genes revealed co-circulation of both the Yamagata and Victoria lineages within the same season in these countries. Our analysis revealed, that a large proportion of viruses circulating during 2013-2014 in Japan and Vietnam were mismatched to the vaccine supporting the rationale for using quadrivalent vaccines. Molecular analysis of the neuraminidase (NA) genes did not reveal any of the previously reported substitutions associated with reduced susceptibility to neuraminidase inhibitors (NAIs). However, one isolate from Nagasaki displayed reduced inhibition by NAIs, associated with an NA-M426I substitution (N2-numbering). Phylogenetic analysis of the eight genome segments identified a 6 + 2 reassortant strain belonging to the Victoria lineage that circulated in Japan during the 2013-2014 season. This strain appears to have evolved from a descendent of a B/Brisbane/60/2008-like strain in an intra-lineage reassortment event involving the nucleoprotein (NP) and nonstructural (NS) genes. Therefore, influenza B strains circulating worldwide continue to evolve via complex reassortment events, which contribute to their survival and the emergence of new strains. These findings highlight the need for ongoing genome-wide studies of circulating viruses and assessing the implications of these evolutionary events on the vaccines.
Persistent Identifierhttp://hdl.handle.net/10722/263775
ISSN
2019 Impact Factor: 2.773
2015 SCImago Journal Rankings: 1.431
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHibino, A-
dc.contributor.authorMassaad, E-
dc.contributor.authorKondo, H-
dc.contributor.authorSaito, R-
dc.contributor.authorOdagiri, TY-
dc.contributor.authorTakemae, N-
dc.contributor.authorTsunekuni, R-
dc.contributor.authorSaito, T-
dc.contributor.authorKyaw, Y-
dc.contributor.authorLin, N-
dc.contributor.authorMyint, YY-
dc.contributor.authorTin, HH-
dc.contributor.authorLe Khanh Hang, N-
dc.contributor.authorMai, LQ-
dc.contributor.authorYagami, R-
dc.contributor.authorShobugawa, Y-
dc.contributor.authorLam, TY-
dc.contributor.authorZaraket, H-
dc.date.accessioned2018-10-22T07:44:17Z-
dc.date.available2018-10-22T07:44:17Z-
dc.date.issued2018-
dc.identifier.citationInfection, Genetics and Evolution, 2018, v. 62, p. 27-33-
dc.identifier.issn1567-1348-
dc.identifier.urihttp://hdl.handle.net/10722/263775-
dc.description.abstractInfluenza B viruses of both the Yamagata and the Victoria lineages are implicated in a large proportion of the morbidity and mortality associated with influenza outbreaks. In this study, we characterized the full genomes of 53 influenza B viruses isolated during 2012-2015 in three Asian countries: Japan, Myanmar, and Vietnam. Analysis of the hemagglutinin (HA) genes revealed co-circulation of both the Yamagata and Victoria lineages within the same season in these countries. Our analysis revealed, that a large proportion of viruses circulating during 2013-2014 in Japan and Vietnam were mismatched to the vaccine supporting the rationale for using quadrivalent vaccines. Molecular analysis of the neuraminidase (NA) genes did not reveal any of the previously reported substitutions associated with reduced susceptibility to neuraminidase inhibitors (NAIs). However, one isolate from Nagasaki displayed reduced inhibition by NAIs, associated with an NA-M426I substitution (N2-numbering). Phylogenetic analysis of the eight genome segments identified a 6 + 2 reassortant strain belonging to the Victoria lineage that circulated in Japan during the 2013-2014 season. This strain appears to have evolved from a descendent of a B/Brisbane/60/2008-like strain in an intra-lineage reassortment event involving the nucleoprotein (NP) and nonstructural (NS) genes. Therefore, influenza B strains circulating worldwide continue to evolve via complex reassortment events, which contribute to their survival and the emergence of new strains. These findings highlight the need for ongoing genome-wide studies of circulating viruses and assessing the implications of these evolutionary events on the vaccines.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/meegid-
dc.relation.ispartofInfection, Genetics and Evolution-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleNeuraminidase inhibitor susceptibility and evolutionary analysis of human influenza B isolates from three Asian countries during 2012–2015-
dc.typeArticle-
dc.identifier.emailLam, TY: ttylam@hku.hk-
dc.identifier.authorityLam, TY=rp01733-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.meegid.2018.04.016-
dc.identifier.scopuseid_2-s2.0-85045737752-
dc.identifier.hkuros294131-
dc.identifier.volume62-
dc.identifier.spage27-
dc.identifier.epage33-
dc.identifier.isiWOS:000453654100007-
dc.publisher.placeNetherlands-

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