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Article: Age-specific differences in the dynamics of protective immunity to influenza

TitleAge-specific differences in the dynamics of protective immunity to influenza
Authors
Keywordsantibody response
dynamics
enzyme linked immunosorbent assay
genetic difference
immune response
Issue Date2019
PublisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2019, v. 10 n. 1, p. article no. 1660 How to Cite?
AbstractInfluenza A viruses evolve rapidly to escape host immunity, causing reinfection. The form and duration of protection after each influenza virus infection are poorly understood. We quantify the dynamics of protective immunity by fitting individual-level mechanistic models to longitudinal serology from children and adults. We find that most protection in children but not adults correlates with antibody titers to the hemagglutinin surface protein. Protection against circulating strains wanes to half of peak levels 3.5–7 years after infection in both age groups, and wanes faster against influenza A(H3N2) than A(H1N1)pdm09. Protection against H3N2 lasts longer in adults than in children. Our results suggest that influenza antibody responses shift focus with age from the mutable hemagglutinin head to other epitopes, consistent with the theory of original antigenic sin, and might affect protection. Imprinting, or primary infection with a subtype, has modest to no effect on the risk of non-medically attended infections in adults.
Persistent Identifierhttp://hdl.handle.net/10722/271404
ISSN
2017 Impact Factor: 12.353
2015 SCImago Journal Rankings: 6.539
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorRanjeva, S-
dc.contributor.authorSubramanian, R-
dc.contributor.authorFang, VJ-
dc.contributor.authorLeung, GM-
dc.contributor.authorIp, DKM-
dc.contributor.authorPerera, RAPM-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorCowling, BJ-
dc.contributor.authorCobey, S-
dc.date.accessioned2019-06-24T01:09:12Z-
dc.date.available2019-06-24T01:09:12Z-
dc.date.issued2019-
dc.identifier.citationNature Communications, 2019, v. 10 n. 1, p. article no. 1660-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/271404-
dc.description.abstractInfluenza A viruses evolve rapidly to escape host immunity, causing reinfection. The form and duration of protection after each influenza virus infection are poorly understood. We quantify the dynamics of protective immunity by fitting individual-level mechanistic models to longitudinal serology from children and adults. We find that most protection in children but not adults correlates with antibody titers to the hemagglutinin surface protein. Protection against circulating strains wanes to half of peak levels 3.5–7 years after infection in both age groups, and wanes faster against influenza A(H3N2) than A(H1N1)pdm09. Protection against H3N2 lasts longer in adults than in children. Our results suggest that influenza antibody responses shift focus with age from the mutable hemagglutinin head to other epitopes, consistent with the theory of original antigenic sin, and might affect protection. Imprinting, or primary infection with a subtype, has modest to no effect on the risk of non-medically attended infections in adults.-
dc.languageeng-
dc.publisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectantibody response-
dc.subjectdynamics-
dc.subjectenzyme linked immunosorbent assay-
dc.subjectgenetic difference-
dc.subjectimmune response-
dc.titleAge-specific differences in the dynamics of protective immunity to influenza-
dc.typeArticle-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.emailIp, DKM: dkmip@hku.hk-
dc.identifier.emailPerera, RAPM: mahenp@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.authorityLeung, GM=rp00460-
dc.identifier.authorityIp, DKM=rp00256-
dc.identifier.authorityPerera, RAPM=rp02500-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityCowling, BJ=rp01326-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41467-019-09652-6-
dc.identifier.pmid30971703-
dc.identifier.pmcidPMC6458119-
dc.identifier.scopuseid_2-s2.0-85064244132-
dc.identifier.hkuros298023-
dc.identifier.volume10-
dc.identifier.issue1-
dc.identifier.spagearticle no. 1660-
dc.identifier.epagearticle no. 1660-
dc.publisher.placeUnited Kingdom-

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