File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Enhancing the antitumor activity of tea polyphenols encapsulated in biodegradable nanogels by macromolecular self-assembly

TitleEnhancing the antitumor activity of tea polyphenols encapsulated in biodegradable nanogels by macromolecular self-assembly
Authors
KeywordsBiocompatibility
Cell death
Drug products
Macromolecules
Medical applications
Issue Date2019
PublisherRoyal Society of Chemistry: Open Access. The Journal's web site is located at http://pubs.rsc.org/en/journals/journalissues/ra
Citation
RSC Advances, 2019, v. 9, p. 10004-10016 How to Cite?
AbstractNanogels (NGs) with desirable stability have emerged as a promising platform for biomedical applications. Herein, a convenient approach was developed to encapsulate and protect tea polyphenols (TPs) by macromolecular self-assembly of lysozyme (Ly) and carboxymethyl cellulose (CMC) through a heating treatment. Biodegradable Ly–CMC NGs were formed on the basis of molecules driven by electrostatic interaction and hydrophobic forces. The particle size and morphology of the Ly–CMC NGs were analyzed using a Malvern particle size analyzer, fluorescence spectrophotometer, and scanning electron microscope. The results showed that the heated NGs were spherical with better stability and smaller particle size. The encapsulation efficiency of TP-loaded NGs was 89.05 ± 3.14%, and it indicated that the Ly–CMC NGs may have a strong binding force with TPs. Moreover, TP-loaded NGs showed a sustained release feature. The DPPH and ABTS-scavenging rates of the TP-loaded NGs were 76.5% and 86.1%, respectively. The antitumor activity of the TP-loaded NGs can effectively inhibit the proliferation of HepG2 cells. Furthermore, TP-loaded NGs were proven to significantly enhance the induction of apoptosis in hepatoma cells and exhibit obvious cell cycle arrest. Our results demonstrate that the Ly–CMC NGs have extensive application prospects as a biocompatible and biodegradable delivery carrier of food functional factors to improve their antitumor effects.
Persistent Identifierhttp://hdl.handle.net/10722/272517
ISSN
2018 Impact Factor: 3.049
2015 SCImago Journal Rankings: 0.990

 

DC FieldValueLanguage
dc.contributor.authorLiu, C-
dc.contributor.authorZhang, Z-
dc.contributor.authorKong, Q-
dc.contributor.authorZhang, R-
dc.contributor.authorYang, X-
dc.date.accessioned2019-07-20T10:43:48Z-
dc.date.available2019-07-20T10:43:48Z-
dc.date.issued2019-
dc.identifier.citationRSC Advances, 2019, v. 9, p. 10004-10016-
dc.identifier.issn2046-2069-
dc.identifier.urihttp://hdl.handle.net/10722/272517-
dc.description.abstractNanogels (NGs) with desirable stability have emerged as a promising platform for biomedical applications. Herein, a convenient approach was developed to encapsulate and protect tea polyphenols (TPs) by macromolecular self-assembly of lysozyme (Ly) and carboxymethyl cellulose (CMC) through a heating treatment. Biodegradable Ly–CMC NGs were formed on the basis of molecules driven by electrostatic interaction and hydrophobic forces. The particle size and morphology of the Ly–CMC NGs were analyzed using a Malvern particle size analyzer, fluorescence spectrophotometer, and scanning electron microscope. The results showed that the heated NGs were spherical with better stability and smaller particle size. The encapsulation efficiency of TP-loaded NGs was 89.05 ± 3.14%, and it indicated that the Ly–CMC NGs may have a strong binding force with TPs. Moreover, TP-loaded NGs showed a sustained release feature. The DPPH and ABTS-scavenging rates of the TP-loaded NGs were 76.5% and 86.1%, respectively. The antitumor activity of the TP-loaded NGs can effectively inhibit the proliferation of HepG2 cells. Furthermore, TP-loaded NGs were proven to significantly enhance the induction of apoptosis in hepatoma cells and exhibit obvious cell cycle arrest. Our results demonstrate that the Ly–CMC NGs have extensive application prospects as a biocompatible and biodegradable delivery carrier of food functional factors to improve their antitumor effects.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry: Open Access. The Journal's web site is located at http://pubs.rsc.org/en/journals/journalissues/ra-
dc.relation.ispartofRSC Advances-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBiocompatibility-
dc.subjectCell death-
dc.subjectDrug products-
dc.subjectMacromolecules-
dc.subjectMedical applications-
dc.titleEnhancing the antitumor activity of tea polyphenols encapsulated in biodegradable nanogels by macromolecular self-assembly-
dc.typeArticle-
dc.identifier.emailZhang, Z: zzhang01@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1039/C8RA07783E-
dc.identifier.scopuseid_2-s2.0-85063956186-
dc.identifier.hkuros298730-
dc.identifier.volume9-
dc.identifier.spage10004-
dc.identifier.epage10016-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats