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Article: Nanoscale Bupivacaine Formulations To Enhance the Duration and Safety of Intravenous Regional Anesthesia

TitleNanoscale Bupivacaine Formulations To Enhance the Duration and Safety of Intravenous Regional Anesthesia
Authors
Keywordsmicelle
bupivacaine
intravenous regional anesthesia
safety
liposome
Issue Date2019
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/ancac3/index.html
Citation
ACS Nano, 2019, v. 13 n. 1, p. 18-25 How to Cite?
AbstractIntravenous regional anesthesia (IVRA; Bier block) is commonly used to anesthetize an extremity for surgery. Limitations of the procedure include pain from the required tourniquet, the toxicity that can occur from systemic release of local anesthetics, and the lack of postoperative pain relief. We hypothesized that the nanoencapsulation of the local anesthetic would prolong local anesthesia and enhance safety. Here, we developed an ∼15 nm micellar bupivacaine formulation (M-Bup) and tested it in a rat tail vein IVRA model, in which active agents were restricted in the tail by a tourniquet for 15 min. After tourniquet removal, M-Bup provided local anesthesia for 4.5 h, which was two times longer than that from a larger dose of free bupivacaine. Approximately 100 nm liposomal bupivacaine (L-Bup) with the same drug dose as M-Bup did not cause anesthesia. Blood levels of bupivacaine after tourniquet removal were lower in animals receiving M-Bup than L-Bup or free bupivacaine, demonstrating enhanced safety. Tissue reaction to M-Bup was benign.
Persistent Identifierhttp://hdl.handle.net/10722/272788
ISSN
2017 Impact Factor: 13.709
2015 SCImago Journal Rankings: 7.120

 

DC FieldValueLanguage
dc.contributor.authorWeldon, C-
dc.contributor.authorJi, T-
dc.contributor.authorNguyen, MT-
dc.contributor.authorRwei, A-
dc.contributor.authorWang, W-
dc.contributor.authorHao, Y-
dc.contributor.authorZhao, C-
dc.contributor.authorMehta, M-
dc.contributor.authorWang, BY-
dc.contributor.authorTsui, J-
dc.contributor.authorMarini, RP-
dc.contributor.authorKohane, DS-
dc.date.accessioned2019-08-06T09:16:34Z-
dc.date.available2019-08-06T09:16:34Z-
dc.date.issued2019-
dc.identifier.citationACS Nano, 2019, v. 13 n. 1, p. 18-25-
dc.identifier.issn1936-0851-
dc.identifier.urihttp://hdl.handle.net/10722/272788-
dc.description.abstractIntravenous regional anesthesia (IVRA; Bier block) is commonly used to anesthetize an extremity for surgery. Limitations of the procedure include pain from the required tourniquet, the toxicity that can occur from systemic release of local anesthetics, and the lack of postoperative pain relief. We hypothesized that the nanoencapsulation of the local anesthetic would prolong local anesthesia and enhance safety. Here, we developed an ∼15 nm micellar bupivacaine formulation (M-Bup) and tested it in a rat tail vein IVRA model, in which active agents were restricted in the tail by a tourniquet for 15 min. After tourniquet removal, M-Bup provided local anesthesia for 4.5 h, which was two times longer than that from a larger dose of free bupivacaine. Approximately 100 nm liposomal bupivacaine (L-Bup) with the same drug dose as M-Bup did not cause anesthesia. Blood levels of bupivacaine after tourniquet removal were lower in animals receiving M-Bup than L-Bup or free bupivacaine, demonstrating enhanced safety. Tissue reaction to M-Bup was benign.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/ancac3/index.html-
dc.relation.ispartofACS Nano-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.subjectmicelle-
dc.subjectbupivacaine-
dc.subjectintravenous regional anesthesia-
dc.subjectsafety-
dc.subjectliposome-
dc.titleNanoscale Bupivacaine Formulations To Enhance the Duration and Safety of Intravenous Regional Anesthesia-
dc.typeArticle-
dc.identifier.emailWang, W: wangwp@hku.hk-
dc.identifier.authorityWang, W=rp02227-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acsnano.8b05408-
dc.identifier.pmid30351910-
dc.identifier.scopuseid_2-s2.0-85057518173-
dc.identifier.hkuros300383-
dc.identifier.volume13-
dc.identifier.issue1-
dc.identifier.spage18-
dc.identifier.epage25-
dc.publisher.placeUnited States-

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