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- Publisher Website: 10.1007/s11095-019-2581-z
- Scopus: eid_2-s2.0-85062590886
- PMID: 30850894
- WOS: WOS:000460785800001
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Article: A Multifunctional Hydrogel Delivers Gold Compound and Inhibits Human Lung Cancer Xenograft
| Title | A Multifunctional Hydrogel Delivers Gold Compound and Inhibits Human Lung Cancer Xenograft |
|---|---|
| Authors | |
| Keywords | cancer gel-PEG-Cys gold porphyrin in situ interpenetrating network system (IPN) |
| Issue Date | 2019 |
| Publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741 |
| Citation | Pharmaceutical Research, 2019, v. 36, p. article no. 61 How to Cite? |
| Abstract | Purpose:
Interpenetrating network system (IPN), consisting of polyethylene glycol (PEG) –diacrylate (PEGdA) and modified gelatin, is a biocompatible and biodegradable hydrogel and has been studied for the local delivery of bioactive molecules and drugs. Gold(III) porphyrin(AuP) is a stable metal compound in the development for anticancer application when administered systemically. The aim of this work is to develop a novel formulation for AuP based on IPN for local delivery.
Methods:
IPN loaded with AuP hydrogel was optimized and synthesized. Drug release kinetics, cytotoxicity against tumor cells, and antitumor activity in lung cancer bearing nude mice were studied.
Results:
AuP released from the IPN followed a first order kinetics in vitro. The AuP loaded IPN showed higher cytotoxicity against human lung cancer cell lines compared to IPN only. In mice bearing human lung cancer xenograft, AuP loaded IPN inhibited tumor growth and reduced angiogenesis. No sign of systemic toxicity was observed for all treatment groups.
Conclusion:
AuP loaded IPN provides an improved formulation over systemic delivery for tumor inhibition to complement surgical intervention. |
| Persistent Identifier | http://hdl.handle.net/10722/272835 |
| ISSN | 2021 Impact Factor: 4.580 2020 SCImago Journal Rankings: 0.815 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lee, P | - |
| dc.contributor.author | Lok, CN | - |
| dc.contributor.author | Che, CM | - |
| dc.contributor.author | Kao, WJ | - |
| dc.date.accessioned | 2019-08-06T09:17:27Z | - |
| dc.date.available | 2019-08-06T09:17:27Z | - |
| dc.date.issued | 2019 | - |
| dc.identifier.citation | Pharmaceutical Research, 2019, v. 36, p. article no. 61 | - |
| dc.identifier.issn | 0724-8741 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/272835 | - |
| dc.description.abstract | Purpose: Interpenetrating network system (IPN), consisting of polyethylene glycol (PEG) –diacrylate (PEGdA) and modified gelatin, is a biocompatible and biodegradable hydrogel and has been studied for the local delivery of bioactive molecules and drugs. Gold(III) porphyrin(AuP) is a stable metal compound in the development for anticancer application when administered systemically. The aim of this work is to develop a novel formulation for AuP based on IPN for local delivery. Methods: IPN loaded with AuP hydrogel was optimized and synthesized. Drug release kinetics, cytotoxicity against tumor cells, and antitumor activity in lung cancer bearing nude mice were studied. Results: AuP released from the IPN followed a first order kinetics in vitro. The AuP loaded IPN showed higher cytotoxicity against human lung cancer cell lines compared to IPN only. In mice bearing human lung cancer xenograft, AuP loaded IPN inhibited tumor growth and reduced angiogenesis. No sign of systemic toxicity was observed for all treatment groups. Conclusion: AuP loaded IPN provides an improved formulation over systemic delivery for tumor inhibition to complement surgical intervention. | - |
| dc.language | eng | - |
| dc.publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741 | - |
| dc.relation.ispartof | Pharmaceutical Research | - |
| dc.rights | This is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: http://dx.doi.org/[insert DOI] | - |
| dc.subject | cancer | - |
| dc.subject | gel-PEG-Cys | - |
| dc.subject | gold porphyrin | - |
| dc.subject | in situ interpenetrating network system (IPN) | - |
| dc.title | A Multifunctional Hydrogel Delivers Gold Compound and Inhibits Human Lung Cancer Xenograft | - |
| dc.type | Article | - |
| dc.identifier.email | Lee, P: puiyanle@HKUCC-COM.hku.hk | - |
| dc.identifier.email | Lok, CN: cnlok@hkucc.hku.hk | - |
| dc.identifier.email | Che, CM: chemhead@hku.hk | - |
| dc.identifier.email | Kao, WJ: wjkao@hku.hk | - |
| dc.identifier.authority | Lok, CN=rp00752 | - |
| dc.identifier.authority | Che, CM=rp00670 | - |
| dc.identifier.authority | Kao, WJ=rp02076 | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1007/s11095-019-2581-z | - |
| dc.identifier.pmid | 30850894 | - |
| dc.identifier.scopus | eid_2-s2.0-85062590886 | - |
| dc.identifier.hkuros | 299663 | - |
| dc.identifier.volume | 36 | - |
| dc.identifier.spage | article no. 61 | - |
| dc.identifier.epage | article no. 61 | - |
| dc.identifier.isi | WOS:000460785800001 | - |
| dc.publisher.place | United States | - |
| dc.identifier.issnl | 0724-8741 | - |