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Article: A Multifunctional Hydrogel Delivers Gold Compound and Inhibits Human Lung Cancer Xenograft

TitleA Multifunctional Hydrogel Delivers Gold Compound and Inhibits Human Lung Cancer Xenograft
Authors
Keywordscancer
gel-PEG-Cys
gold porphyrin
in situ interpenetrating network system (IPN)
Issue Date2019
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741
Citation
Pharmaceutical Research, 2019, v. 36, p. article no. 61 How to Cite?
AbstractPurpose: Interpenetrating network system (IPN), consisting of polyethylene glycol (PEG) –diacrylate (PEGdA) and modified gelatin, is a biocompatible and biodegradable hydrogel and has been studied for the local delivery of bioactive molecules and drugs. Gold(III) porphyrin(AuP) is a stable metal compound in the development for anticancer application when administered systemically. The aim of this work is to develop a novel formulation for AuP based on IPN for local delivery. Methods: IPN loaded with AuP hydrogel was optimized and synthesized. Drug release kinetics, cytotoxicity against tumor cells, and antitumor activity in lung cancer bearing nude mice were studied. Results: AuP released from the IPN followed a first order kinetics in vitro. The AuP loaded IPN showed higher cytotoxicity against human lung cancer cell lines compared to IPN only. In mice bearing human lung cancer xenograft, AuP loaded IPN inhibited tumor growth and reduced angiogenesis. No sign of systemic toxicity was observed for all treatment groups. Conclusion: AuP loaded IPN provides an improved formulation over systemic delivery for tumor inhibition to complement surgical intervention.
Persistent Identifierhttp://hdl.handle.net/10722/272835
ISSN
2017 Impact Factor: 3.335
2015 SCImago Journal Rankings: 1.189

 

DC FieldValueLanguage
dc.contributor.authorLee, P-
dc.contributor.authorLok, CN-
dc.contributor.authorChe, CM-
dc.contributor.authorKao, WJ-
dc.date.accessioned2019-08-06T09:17:27Z-
dc.date.available2019-08-06T09:17:27Z-
dc.date.issued2019-
dc.identifier.citationPharmaceutical Research, 2019, v. 36, p. article no. 61-
dc.identifier.issn0724-8741-
dc.identifier.urihttp://hdl.handle.net/10722/272835-
dc.description.abstractPurpose: Interpenetrating network system (IPN), consisting of polyethylene glycol (PEG) –diacrylate (PEGdA) and modified gelatin, is a biocompatible and biodegradable hydrogel and has been studied for the local delivery of bioactive molecules and drugs. Gold(III) porphyrin(AuP) is a stable metal compound in the development for anticancer application when administered systemically. The aim of this work is to develop a novel formulation for AuP based on IPN for local delivery. Methods: IPN loaded with AuP hydrogel was optimized and synthesized. Drug release kinetics, cytotoxicity against tumor cells, and antitumor activity in lung cancer bearing nude mice were studied. Results: AuP released from the IPN followed a first order kinetics in vitro. The AuP loaded IPN showed higher cytotoxicity against human lung cancer cell lines compared to IPN only. In mice bearing human lung cancer xenograft, AuP loaded IPN inhibited tumor growth and reduced angiogenesis. No sign of systemic toxicity was observed for all treatment groups. Conclusion: AuP loaded IPN provides an improved formulation over systemic delivery for tumor inhibition to complement surgical intervention.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741-
dc.relation.ispartofPharmaceutical Research-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: http://dx.doi.org/[insert DOI]-
dc.subjectcancer-
dc.subjectgel-PEG-Cys-
dc.subjectgold porphyrin-
dc.subjectin situ interpenetrating network system (IPN)-
dc.titleA Multifunctional Hydrogel Delivers Gold Compound and Inhibits Human Lung Cancer Xenograft-
dc.typeArticle-
dc.identifier.emailLee, P: puiyanle@HKUCC-COM.hku.hk-
dc.identifier.emailLok, CN: cnlok@hkucc.hku.hk-
dc.identifier.emailChe, CM: chemhead@hku.hk-
dc.identifier.emailKao, WJ: wjkao@hku.hk-
dc.identifier.authorityLok, CN=rp00752-
dc.identifier.authorityChe, CM=rp00670-
dc.identifier.authorityKao, WJ=rp02076-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11095-019-2581-z-
dc.identifier.pmid30850894-
dc.identifier.scopuseid_2-s2.0-85062590886-
dc.identifier.hkuros299663-
dc.identifier.volume36-
dc.identifier.spagearticle no. 61-
dc.identifier.epagearticle no. 61-
dc.publisher.placeUnited States-

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