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Article: Risk factors for the development of post-operative enterocolitis in short segment Hirschsprung’s disease

TitleRisk factors for the development of post-operative enterocolitis in short segment Hirschsprung’s disease
Authors
KeywordsHirschsprung’s disease
Enterocolitis
Defunctioning stoma
Dysbiosis
Issue Date2019
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00383/index.htm
Citation
Pediatric Surgery International, 2019, v. 35 n. 2, p. 187-191 How to Cite?
AbstractAim of the study: The objective of this study is to identify risk factors associated with the development of post-operative enterocolitis (HAEC), in short segment Hirschsprung’s disease (HSCR-S). Methods: A retrospective study was carried out for post-operative patients with HSCR-S from 1997 to 2017. HSCR-S was defined as the most proximal extension of aganglionosis limited to the sigmoid colon. An episode of HAEC was defined as the presence of (1) vomiting or explosive diarrhea; (2) abdominal distension; (3) fever and (4) leukocytosis. Risk factors for the development of HACE were determined using multivariate logistic regression. Main results: The medical records of 96 patients were reviewed. The overall incidence of HAEC was 20.8% (n = 20) and 65.0% (n = 13) of HAEC occurred within the first year of operation. After a univariate logistic regression analysis, three risk factors for HAEC were identified: (1) presence of other major anomalies [OR: 1.43 (1.12–2.32), p = 0.041]; (2) creation of pre-operative defunctioning stoma [OR: 2.28 (1.47–3.23), p = 0.035]; (3) extension of aganglionosis to the sigmoid colon [OR: 1.89 (1.05–3.19), p = 0.049]. After multivariate logistic regression analysis, a significant association was demonstrated for creation of pre-operative defunctioning stoma [OR: 1.81 (1.08–3.22), p = 0.045] and extension of aganglionosis to the sigmoid colon [OR: 1.91 (1.37–2.98), p = 0.038]. Conclusions: The requirement of pre-operative defunctioning stoma and a more proximal extension of aganglionosis are risk factors for the development of post-operative HAEC in HSCR-S. Patients with these risk factors should be closely followed up especially during the first year after the operation.
Persistent Identifierhttp://hdl.handle.net/10722/272977
ISSN
2019 Impact Factor: 1.668
2015 SCImago Journal Rankings: 0.409
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChung, PHY-
dc.contributor.authorYu, MON-
dc.contributor.authorWong, KKY-
dc.contributor.authorTam, PKH-
dc.date.accessioned2019-08-06T09:20:15Z-
dc.date.available2019-08-06T09:20:15Z-
dc.date.issued2019-
dc.identifier.citationPediatric Surgery International, 2019, v. 35 n. 2, p. 187-191-
dc.identifier.issn0179-0358-
dc.identifier.urihttp://hdl.handle.net/10722/272977-
dc.description.abstractAim of the study: The objective of this study is to identify risk factors associated with the development of post-operative enterocolitis (HAEC), in short segment Hirschsprung’s disease (HSCR-S). Methods: A retrospective study was carried out for post-operative patients with HSCR-S from 1997 to 2017. HSCR-S was defined as the most proximal extension of aganglionosis limited to the sigmoid colon. An episode of HAEC was defined as the presence of (1) vomiting or explosive diarrhea; (2) abdominal distension; (3) fever and (4) leukocytosis. Risk factors for the development of HACE were determined using multivariate logistic regression. Main results: The medical records of 96 patients were reviewed. The overall incidence of HAEC was 20.8% (n = 20) and 65.0% (n = 13) of HAEC occurred within the first year of operation. After a univariate logistic regression analysis, three risk factors for HAEC were identified: (1) presence of other major anomalies [OR: 1.43 (1.12–2.32), p = 0.041]; (2) creation of pre-operative defunctioning stoma [OR: 2.28 (1.47–3.23), p = 0.035]; (3) extension of aganglionosis to the sigmoid colon [OR: 1.89 (1.05–3.19), p = 0.049]. After multivariate logistic regression analysis, a significant association was demonstrated for creation of pre-operative defunctioning stoma [OR: 1.81 (1.08–3.22), p = 0.045] and extension of aganglionosis to the sigmoid colon [OR: 1.91 (1.37–2.98), p = 0.038]. Conclusions: The requirement of pre-operative defunctioning stoma and a more proximal extension of aganglionosis are risk factors for the development of post-operative HAEC in HSCR-S. Patients with these risk factors should be closely followed up especially during the first year after the operation.-
dc.languageeng-
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00383/index.htm-
dc.relation.ispartofPediatric Surgery International-
dc.subjectHirschsprung’s disease-
dc.subjectEnterocolitis-
dc.subjectDefunctioning stoma-
dc.subjectDysbiosis-
dc.titleRisk factors for the development of post-operative enterocolitis in short segment Hirschsprung’s disease-
dc.typeArticle-
dc.identifier.emailChung, PHY: chungphy@hku.hk-
dc.identifier.emailWong, KKY: kkywong@hku.hk-
dc.identifier.emailTam, PKH: paultam@hku.hk-
dc.identifier.authorityChung, PHY=rp02002-
dc.identifier.authorityWong, KKY=rp01392-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00383-018-4393-3-
dc.identifier.pmid30386902-
dc.identifier.scopuseid_2-s2.0-85055972845-
dc.identifier.hkuros299598-
dc.identifier.volume35-
dc.identifier.issue2-
dc.identifier.spage187-
dc.identifier.epage191-
dc.identifier.isiWOS:000456316100003-
dc.publisher.placeGermany-

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