File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles

TitleIntravenous treatment of choroidal neovascularization by photo-targeted nanoparticles
Authors
Issue Date2019
PublisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2019, v. 10, p. 804 How to Cite?
AbstractChoroidal neovascularization (CNV) is the major cause of vision loss in wet age-related macular degeneration (AMD). Current therapies require repeated intravitreal injections, which are painful and can cause infection, bleeding, and retinal detachment. Here we develop nanoparticles (NP-[CPP]) that can be administered intravenously and allow local drug delivery to the diseased choroid via light-triggered targeting. NP-[CPP] is formed by PEG-PLA chains modified with a cell penetrating peptide (CPP). Attachment of a DEACM photocleavable group to the CPP inhibits cellular uptake of NP-[CPP]. Irradiation with blue light cleaves DEACM from the CPP, allowing the CPP to migrate from the NP core to the surface, rendering it active. In mice with laser-induced CNV, intravenous injection of NP-[CPP] coupled to irradiation of the eye allows NP accumulation in the neovascular lesions. When loaded with doxorubicin, irradiated NP-[CPP] significantly reduces neovascular lesion size. We propose a strategy for non-invasive treatment of CNV and enhanced drug accumulation specifically in diseased areas of the eye.
Persistent Identifierhttp://hdl.handle.net/10722/273369
ISSN
2017 Impact Factor: 12.353
2015 SCImago Journal Rankings: 6.539
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Y-
dc.contributor.authorLiu, CH-
dc.contributor.authorJi, T-
dc.contributor.authorMehta, M-
dc.contributor.authorWang, W-
dc.contributor.authorMarino, E-
dc.contributor.authorChen, J-
dc.contributor.authorKohane, DS-
dc.date.accessioned2019-08-06T09:27:37Z-
dc.date.available2019-08-06T09:27:37Z-
dc.date.issued2019-
dc.identifier.citationNature Communications, 2019, v. 10, p. 804-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/273369-
dc.description.abstractChoroidal neovascularization (CNV) is the major cause of vision loss in wet age-related macular degeneration (AMD). Current therapies require repeated intravitreal injections, which are painful and can cause infection, bleeding, and retinal detachment. Here we develop nanoparticles (NP-[CPP]) that can be administered intravenously and allow local drug delivery to the diseased choroid via light-triggered targeting. NP-[CPP] is formed by PEG-PLA chains modified with a cell penetrating peptide (CPP). Attachment of a DEACM photocleavable group to the CPP inhibits cellular uptake of NP-[CPP]. Irradiation with blue light cleaves DEACM from the CPP, allowing the CPP to migrate from the NP core to the surface, rendering it active. In mice with laser-induced CNV, intravenous injection of NP-[CPP] coupled to irradiation of the eye allows NP accumulation in the neovascular lesions. When loaded with doxorubicin, irradiated NP-[CPP] significantly reduces neovascular lesion size. We propose a strategy for non-invasive treatment of CNV and enhanced drug accumulation specifically in diseased areas of the eye.-
dc.languageeng-
dc.publisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleIntravenous treatment of choroidal neovascularization by photo-targeted nanoparticles-
dc.typeArticle-
dc.identifier.emailWang, W: wangwp@hku.hk-
dc.identifier.authorityWang, W=rp02227-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41467-019-08690-4-
dc.identifier.pmid30778060-
dc.identifier.scopuseid_2-s2.0-85061756191-
dc.identifier.hkuros300387-
dc.identifier.volume10-
dc.identifier.spage804-
dc.identifier.epage804-
dc.identifier.isiWOS:000458864600007-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats