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Conference Paper: Clinical associations with serum syndecan-1 level in patients with lupus nephritis

TitleClinical associations with serum syndecan-1 level in patients with lupus nephritis
Authors
Issue Date2018
PublisherAmerican Society of Nephrology. The Journal's web site is located at http://www.jasn.org
Citation
American Society of Nephrology (ASN) Kidney Week 2018, San Diego, California, USA, 23-28 October 2018. In Journal of the American Society of Nephrology, 2018, v. 29 n. Abstract Suppl., p. 334 How to Cite?
AbstractBackground: Cardiovascular disease is an important long-term complication in patients with lupus nephritis. The endothelial glycocalyx regulates the adhesiveness of circulating cells to vascular endothelial cells and vascular permeability. Syndecan-1 is a component of the endothelial glycocalyx, and syndecan-1 shedding occurs in endothelial cell activation or injury. Methods: Serial serum samples from patients with biopsy-proven Class III/IV lupus nephritis were obtained at intervals of 3-4 months over two years. In addition, paired samples with one obtained during flare and the other during remission were included. Sera from age- and sex-matched patients with IgA nephropathy (IgAN), SLE patients without nephritis, and healthy subjects were included as controls (n=25 for each group). Serum syndecan-1 level was determined by ELISA. Results: Four hundred and sixty sera from 29 lupus nephritis patients (20 females and 9 males; age 39.0±10.2 years; disease duration 7.6±8.6 years) were studied. Serum syndecan-1 level was significantly higher during active lupus nephritis compared with remission, and also the IgAN, non-renal lupus, and healthy control groups (P<0.001, for all). Syndecan-1 level correlated with SLEDAI (r=0.535, P<0.001), anti-dsDNA antibody level (r=0.407, P=0.003), serum creatinine level (r=0.262, P=0.05), proteinuria (r=0.571, P<0.001), and inversely correlated with serum C3 (r=-0.443, P=0.001) and albumin levels (r=-0.568, P<0.001). Circulating syndecan-1 level showed a temporal relationship with disease activity and changes in anti-dsDNA antibody and C3 levels. ROC curve analysis showed that serum syndecan-1 level distinguished active lupus nephritis from healthy subjects with sensitivity and specificity rates of 96.3% and 96.0% respectively, from IgAN patients with respective rates of 85.2% and 91.3%, and from non-renal lupus patients with respective rates of 85.7% and 70.4% (P<0.0001, for all). Conclusions: Active lupus nephritis is associated with increased circulating syndecan-1 level, and thus may contribute towards the pathogenesis of cardiovascular complications in patients with lupus nephritis.
DescriptionPoster presentation - Session: Glomerular Diseases: Immunology and Inflammation - I: abstract no. TH-PO825
Persistent Identifierhttp://hdl.handle.net/10722/273442
ISSN
2019 Impact Factor: 9.274
2015 SCImago Journal Rankings: 4.699

 

DC FieldValueLanguage
dc.contributor.authorYung, SSY-
dc.contributor.authorYu, K-
dc.contributor.authorChau, KM-
dc.contributor.authorCheung, KF-
dc.contributor.authorChan, DTM-
dc.date.accessioned2019-08-06T09:29:02Z-
dc.date.available2019-08-06T09:29:02Z-
dc.date.issued2018-
dc.identifier.citationAmerican Society of Nephrology (ASN) Kidney Week 2018, San Diego, California, USA, 23-28 October 2018. In Journal of the American Society of Nephrology, 2018, v. 29 n. Abstract Suppl., p. 334-
dc.identifier.issn1046-6673-
dc.identifier.urihttp://hdl.handle.net/10722/273442-
dc.descriptionPoster presentation - Session: Glomerular Diseases: Immunology and Inflammation - I: abstract no. TH-PO825-
dc.description.abstractBackground: Cardiovascular disease is an important long-term complication in patients with lupus nephritis. The endothelial glycocalyx regulates the adhesiveness of circulating cells to vascular endothelial cells and vascular permeability. Syndecan-1 is a component of the endothelial glycocalyx, and syndecan-1 shedding occurs in endothelial cell activation or injury. Methods: Serial serum samples from patients with biopsy-proven Class III/IV lupus nephritis were obtained at intervals of 3-4 months over two years. In addition, paired samples with one obtained during flare and the other during remission were included. Sera from age- and sex-matched patients with IgA nephropathy (IgAN), SLE patients without nephritis, and healthy subjects were included as controls (n=25 for each group). Serum syndecan-1 level was determined by ELISA. Results: Four hundred and sixty sera from 29 lupus nephritis patients (20 females and 9 males; age 39.0±10.2 years; disease duration 7.6±8.6 years) were studied. Serum syndecan-1 level was significantly higher during active lupus nephritis compared with remission, and also the IgAN, non-renal lupus, and healthy control groups (P<0.001, for all). Syndecan-1 level correlated with SLEDAI (r=0.535, P<0.001), anti-dsDNA antibody level (r=0.407, P=0.003), serum creatinine level (r=0.262, P=0.05), proteinuria (r=0.571, P<0.001), and inversely correlated with serum C3 (r=-0.443, P=0.001) and albumin levels (r=-0.568, P<0.001). Circulating syndecan-1 level showed a temporal relationship with disease activity and changes in anti-dsDNA antibody and C3 levels. ROC curve analysis showed that serum syndecan-1 level distinguished active lupus nephritis from healthy subjects with sensitivity and specificity rates of 96.3% and 96.0% respectively, from IgAN patients with respective rates of 85.2% and 91.3%, and from non-renal lupus patients with respective rates of 85.7% and 70.4% (P<0.0001, for all). Conclusions: Active lupus nephritis is associated with increased circulating syndecan-1 level, and thus may contribute towards the pathogenesis of cardiovascular complications in patients with lupus nephritis.-
dc.languageeng-
dc.publisherAmerican Society of Nephrology. The Journal's web site is located at http://www.jasn.org-
dc.relation.ispartofJournal of the American Society of Nephrology-
dc.relation.ispartofAmerican Society of Nephrology Kidney Week 2018-
dc.titleClinical associations with serum syndecan-1 level in patients with lupus nephritis-
dc.typeConference_Paper-
dc.identifier.emailYung, SSY: ssyyung@hku.hk-
dc.identifier.emailChan, DTM: dtmchan@hkucc.hku.hk-
dc.identifier.authorityYung, SSY=rp00455-
dc.identifier.authorityChan, DTM=rp00394-
dc.identifier.hkuros299786-
dc.identifier.volume29-
dc.identifier.issueAbstract Suppl.-
dc.identifier.spage334-
dc.identifier.epage334-
dc.publisher.placeUnited States-

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