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Article: Contribution of Mitophagy to Cell-Mediated Mineralization: Revisiting a 50-Year-Old Conundrum

TitleContribution of Mitophagy to Cell-Mediated Mineralization: Revisiting a 50-Year-Old Conundrum
Authors
Keywordsamorphous calcium phosphate
mineralization
mitophagy
osteogenesis
Issue Date2018
PublisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844
Citation
Advanced Science, 2018, v. 5 n. 10, p. article no. 1800873 How to Cite?
AbstractBiomineralization in vertebrates is initiated via amorphous calcium phosphate (ACP) precursors. These precursors infiltrate the extracellular collagen matrix where they undergo phase transformation into intrafibrillar carbonated apatite. Although it is well established that ACP precursors are released from intracellular vesicles through exocytosis, an unsolved enigma in this cell‐mediated mineralization process is how ACP precursors, initially produced in the mitochondria, are translocated to the intracellular vesicles. The present study proposes that mitophagy provides the mechanism for transfer of ACP precursors from the dysfunctioned mitochondria to autophagosomes, which, upon fusion with lysosomes, become autolysosomes where the mitochondrial ACP precursors coalesce to form larger intravesicular granules, prior to their release into the extracellular matrix. Apart from endowing the mitochondria with the function of ACP delivery through mitophagy, the present results indicate that mitophagy, triggered upon intramitochondrial ACP accumulation in osteogenic lineage‐committed mesenchymal stem cells, participates in the biomineralization process through the BMP/Smad signaling pathway.
Persistent Identifierhttp://hdl.handle.net/10722/273831
ISSN
2018 Impact Factor: 15.804
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorPei, DD-
dc.contributor.authorSun, JL-
dc.contributor.authorZhu, CH-
dc.contributor.authorTian, FC-
dc.contributor.authorJiao, K-
dc.contributor.authorAnderson, MK-
dc.contributor.authorYiu, C-
dc.contributor.authorHuang, C-
dc.contributor.authorJin, CX-
dc.contributor.authorBergeron, BE-
dc.contributor.authorChen, JH-
dc.contributor.authorTay, FR-
dc.contributor.authorNiu, LN-
dc.date.accessioned2019-08-18T14:49:26Z-
dc.date.available2019-08-18T14:49:26Z-
dc.date.issued2018-
dc.identifier.citationAdvanced Science, 2018, v. 5 n. 10, p. article no. 1800873-
dc.identifier.issn2198-3844-
dc.identifier.urihttp://hdl.handle.net/10722/273831-
dc.description.abstractBiomineralization in vertebrates is initiated via amorphous calcium phosphate (ACP) precursors. These precursors infiltrate the extracellular collagen matrix where they undergo phase transformation into intrafibrillar carbonated apatite. Although it is well established that ACP precursors are released from intracellular vesicles through exocytosis, an unsolved enigma in this cell‐mediated mineralization process is how ACP precursors, initially produced in the mitochondria, are translocated to the intracellular vesicles. The present study proposes that mitophagy provides the mechanism for transfer of ACP precursors from the dysfunctioned mitochondria to autophagosomes, which, upon fusion with lysosomes, become autolysosomes where the mitochondrial ACP precursors coalesce to form larger intravesicular granules, prior to their release into the extracellular matrix. Apart from endowing the mitochondria with the function of ACP delivery through mitophagy, the present results indicate that mitophagy, triggered upon intramitochondrial ACP accumulation in osteogenic lineage‐committed mesenchymal stem cells, participates in the biomineralization process through the BMP/Smad signaling pathway.-
dc.languageeng-
dc.publisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844-
dc.relation.ispartofAdvanced Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectamorphous calcium phosphate-
dc.subjectmineralization-
dc.subjectmitophagy-
dc.subjectosteogenesis-
dc.titleContribution of Mitophagy to Cell-Mediated Mineralization: Revisiting a 50-Year-Old Conundrum-
dc.typeArticle-
dc.identifier.emailYiu, C: ckyyiu@hkucc.hku.hk-
dc.identifier.emailTay, FR: franktay@hkucc.hku.hk-
dc.identifier.authorityYiu, C=rp00018-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/advs.201800873-
dc.identifier.pmid30356983-
dc.identifier.pmcidPMC6193168-
dc.identifier.scopuseid_2-s2.0-85051066696-
dc.identifier.hkuros301966-
dc.identifier.volume5-
dc.identifier.issue10-
dc.identifier.spagearticle no. 1800873-
dc.identifier.epagearticle no. 1800873-
dc.publisher.placeGermany-

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