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Article: Local enrichment of fatty acid-binding protein 4 in the pericardial cavity of cardiovascular disease patients

TitleLocal enrichment of fatty acid-binding protein 4 in the pericardial cavity of cardiovascular disease patients
Authors
Keywordsadult
aged
cardiovascular disease
cardiovascular surgery
coronary artery bypass surgery
Issue Date2018
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2018, v. 13 n. 11, p. article no. e0206802 How to Cite?
AbstractBackground: The pericardial fluid may be representative of the interstitium of the heart. The aim of this study was to discriminate in cardiovascular disease patients between adipocytokines that are produced locally by the heart and those supplied by the circulation. Methods: Enzyme-linked immunosorbent assays (ELISA) were used to determine levels of N-terminal pro-brain natriuretic peptide (NT-pBNP), fatty acid-binding protein 4 (FABP4), leptin, lipocalin-2, neutrophil elastase, proteinase-3, high sensitivity C-reactive protein (hsCRP) and adiponectin in venous plasma and pericardial fluid harvested during elective cardio-thoracic surgery (n = 132–152). Results: In pericardial fluid compared to plasma, the levels were significantly smaller (p < 0.001) for leptin, lipocalin-2, neutrophil elastase, proteinase-3, hsCRP and adiponectin. For these biomarkers, the ratio of pericardial fluid-to-plasma level ([PF]/[P], median (interquartile range)) was 0.65 (0.47–1.01), 0.78 (0.56–1.09), 0.23 (0.11–0.60), 0.17 (0.09–0.36), 0.14 (0.08–0.35), and 0.25 (0.15–0.34), respectively. In contrast, pericardial fluid was significantly enriched (p < 0.001) in NT-pBNP ([PF]/[P]: 1.9 (1.06–2.73)) and even more so for FABP4 ([PF]/[P]: 3.90 (1.47–9.77)). Moreover, in pericardial fluid, the adipocytokines interrelated all significantly positive and correlated negative to hsCRP, whereas for NT-pBNP only a significantly positive correlation with adiponectin was found. These interrelations were distinct from those in the plasma, as were the correlations of the pericardial biomarkers with patient characteristics compared to plasma. Conclusions In cardiovascular disease patients, the pericardial cavity is a distinct adipocytokine microenvironment in which especially FABP4 is mainly derived from the heart.
Persistent Identifierhttp://hdl.handle.net/10722/273932
ISSN
2019 Impact Factor: 2.74
2015 SCImago Journal Rankings: 1.395
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorEllie, AGIM-
dc.contributor.authorBloksgaard, M-
dc.contributor.authorSun, WY-
dc.contributor.authorYang, K-
dc.contributor.authorMan, AWC-
dc.contributor.authorXu, A-
dc.contributor.authorIrmukhamedov, A-
dc.contributor.authorRiber, LP-
dc.contributor.authorWang, Y-
dc.contributor.authorDe Mey, JGR-
dc.date.accessioned2019-08-18T14:51:37Z-
dc.date.available2019-08-18T14:51:37Z-
dc.date.issued2018-
dc.identifier.citationPLoS One, 2018, v. 13 n. 11, p. article no. e0206802-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/273932-
dc.description.abstractBackground: The pericardial fluid may be representative of the interstitium of the heart. The aim of this study was to discriminate in cardiovascular disease patients between adipocytokines that are produced locally by the heart and those supplied by the circulation. Methods: Enzyme-linked immunosorbent assays (ELISA) were used to determine levels of N-terminal pro-brain natriuretic peptide (NT-pBNP), fatty acid-binding protein 4 (FABP4), leptin, lipocalin-2, neutrophil elastase, proteinase-3, high sensitivity C-reactive protein (hsCRP) and adiponectin in venous plasma and pericardial fluid harvested during elective cardio-thoracic surgery (n = 132–152). Results: In pericardial fluid compared to plasma, the levels were significantly smaller (p < 0.001) for leptin, lipocalin-2, neutrophil elastase, proteinase-3, hsCRP and adiponectin. For these biomarkers, the ratio of pericardial fluid-to-plasma level ([PF]/[P], median (interquartile range)) was 0.65 (0.47–1.01), 0.78 (0.56–1.09), 0.23 (0.11–0.60), 0.17 (0.09–0.36), 0.14 (0.08–0.35), and 0.25 (0.15–0.34), respectively. In contrast, pericardial fluid was significantly enriched (p < 0.001) in NT-pBNP ([PF]/[P]: 1.9 (1.06–2.73)) and even more so for FABP4 ([PF]/[P]: 3.90 (1.47–9.77)). Moreover, in pericardial fluid, the adipocytokines interrelated all significantly positive and correlated negative to hsCRP, whereas for NT-pBNP only a significantly positive correlation with adiponectin was found. These interrelations were distinct from those in the plasma, as were the correlations of the pericardial biomarkers with patient characteristics compared to plasma. Conclusions In cardiovascular disease patients, the pericardial cavity is a distinct adipocytokine microenvironment in which especially FABP4 is mainly derived from the heart.-
dc.languageeng-
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLoS One-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectadult-
dc.subjectaged-
dc.subjectcardiovascular disease-
dc.subjectcardiovascular surgery-
dc.subjectcoronary artery bypass surgery-
dc.titleLocal enrichment of fatty acid-binding protein 4 in the pericardial cavity of cardiovascular disease patients-
dc.typeArticle-
dc.identifier.emailSun, WY: kiwisun@hku.hk-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.emailWang, Y: yuwanghk@hku.hk-
dc.identifier.authorityXu, A=rp00485-
dc.identifier.authorityWang, Y=rp00239-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0206802-
dc.identifier.pmid30395653-
dc.identifier.pmcidPMC6218069-
dc.identifier.scopuseid_2-s2.0-85056243848-
dc.identifier.hkuros301599-
dc.identifier.volume13-
dc.identifier.issue11-
dc.identifier.spagearticle no. e0206802-
dc.identifier.epagearticle no. e0206802-
dc.publisher.placeUnited States-

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