Usefulness of lactate-free Asian Pacific Association for The Study of Liver acute-on-chronic liver failure research consortium ACLF score for predicting short-term mortality in patient with alcoholic liver disease

Abstract

Background and aims: Asian Pacific Association for the Study of Liver (APASL) acute-on-chronic liver failure (ACLF) Research Consortium (AARC) proposed new prognostic scoring system of ACLF including lactate. However, lactate is not routinely checked in clinical practice of patient with ACLF in Korea. Therefore, we aimed to investigate the predictive accuracy of lactate-free AARC-ACLF score for predicting short-term mortality in patients with alcoholic liver disease Method: A total of 749 ALD patients who had liver failure (bilirubin ≥ 5mg/dL and INR ≥ 1.5) in AARC database were investigated. Diagnostic performances for short-term mortality were compared according to the area under receiver operating characteristic (AUROC) curve. Predictive accuracy of lactate-free AARC-ACLF score were compared with other prognostic scores in 143 ALD patients with liver failure and 65 ALD patients with ACLF according to AARC definition in Korean ACLF cohort. Results: Among 749 patients, 28-day and 90-day mortality were 40.3% and 51.5%. There were no significant differences in AUROC for predicting 28-day and 90-day mortality between AARC-ACLF score and lactate-free AARC-ACLF score (28-day mortality: 0.758 vs. 0.759, P = 0.938, 90-day mortality: 0.747 vs. 0.740, P = 0.383). In Korean ACLF cohort, the AUROCs of lactate-free AARCACLF score for predicting 28-day and 90-day mortality were 0.861 and 0.846 in ALD with liver failure, and 0.865 and 0.873 in ALD patients with ACLF according to AARC definition, respectively. In Korean ALD patients with liver failure and ACLF according to AARC definition, diagnostic performance of lactate-free AARC-ACLF score for predicting 28-day and 90-day mortality was comparable to those of Model for End-stage Liver Disease (MELD), MELD-Na, Chronic Liver Failure-Sequential Organ Failure Assessment score. Conclusion: Lactate-free AARC-ACLF score is as excellent as AARC-ACLF score in predicting shortterm mortality in ALD patients with liver failure of AARC database and Korean ACLF cohort.