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Article: Utility of Trial-to-Trial Latency Variability of Somatosensory Evoked Potentials for Diagnosis of Spinal Cord Demyelination

TitleUtility of Trial-to-Trial Latency Variability of Somatosensory Evoked Potentials for Diagnosis of Spinal Cord Demyelination
Authors
Keywordssecond order blind identification
single trial extraction
somatosensory evoked potentials (SEPs)
spinal cord demyelination
trial-to-trial latency variability
Issue Date2019
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neu
Citation
Journal of Neurotrauma, 2019, v. 36 n. 24, p. 3356-3362 How to Cite?
AbstractTraditional measurement of somatosensory evoked potentials (SEPs) depends on averaging of many recordings, which introduces loss of dynamic variability. Single trial extraction provides a new measurement of SEP latency variability for evaluation of the neurodynamic status of the somatosensory pathway. The aim of this study was to apply a single trial SEP to diagnose the severity of demyelination in a chronical spinal cord injury model. The severity of demyelination was measured by myelin area and staining intensity at the ventral column (VC), lateral column (LC), and dorsal column (DC) by histological examination with Luxol fast blue staining. Results showed that there was a strong negative correlation of the latency variability of trial-to-trial SEP with the myelin area in three columns (DC: r=-0.90, p<0.05; VC: r=-0.91, p<0.05; LC: r=-0.89, p<0.05), and the staining intensity in three columns (DC: r=-0.95, p<0.05; VC: r=-0.94, p<0.05; LC: r=-0.93, p<0.05). These data suggest that single trial SEP can provide a dynamic indicator of spinal cord demyelination.
Persistent Identifierhttp://hdl.handle.net/10722/276076
ISSN
2019 Impact Factor: 3.793
2015 SCImago Journal Rankings: 1.945

 

DC FieldValueLanguage
dc.contributor.authorCui, H-
dc.contributor.authorLi, H-
dc.contributor.authorLi, G-
dc.contributor.authorKang, C-
dc.contributor.authorYao, X-
dc.contributor.authorFeng, S-
dc.contributor.authorHu, Y-
dc.date.accessioned2019-09-10T02:55:28Z-
dc.date.available2019-09-10T02:55:28Z-
dc.date.issued2019-
dc.identifier.citationJournal of Neurotrauma, 2019, v. 36 n. 24, p. 3356-3362-
dc.identifier.issn0897-7151-
dc.identifier.urihttp://hdl.handle.net/10722/276076-
dc.description.abstractTraditional measurement of somatosensory evoked potentials (SEPs) depends on averaging of many recordings, which introduces loss of dynamic variability. Single trial extraction provides a new measurement of SEP latency variability for evaluation of the neurodynamic status of the somatosensory pathway. The aim of this study was to apply a single trial SEP to diagnose the severity of demyelination in a chronical spinal cord injury model. The severity of demyelination was measured by myelin area and staining intensity at the ventral column (VC), lateral column (LC), and dorsal column (DC) by histological examination with Luxol fast blue staining. Results showed that there was a strong negative correlation of the latency variability of trial-to-trial SEP with the myelin area in three columns (DC: r=-0.90, p<0.05; VC: r=-0.91, p<0.05; LC: r=-0.89, p<0.05), and the staining intensity in three columns (DC: r=-0.95, p<0.05; VC: r=-0.94, p<0.05; LC: r=-0.93, p<0.05). These data suggest that single trial SEP can provide a dynamic indicator of spinal cord demyelination.-
dc.languageeng-
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neu-
dc.relation.ispartofJournal of Neurotrauma-
dc.rightsJournal of Neurotrauma. Copyright © Mary Ann Liebert, Inc Publishers.-
dc.rightsFinal publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/neu.2018.6293-
dc.subjectsecond order blind identification-
dc.subjectsingle trial extraction-
dc.subjectsomatosensory evoked potentials (SEPs)-
dc.subjectspinal cord demyelination-
dc.subjecttrial-to-trial latency variability-
dc.titleUtility of Trial-to-Trial Latency Variability of Somatosensory Evoked Potentials for Diagnosis of Spinal Cord Demyelination-
dc.typeArticle-
dc.identifier.emailLi, H: lihanlei@hku.hk-
dc.identifier.emailHu, Y: yhud@hku.hk-
dc.identifier.authorityHu, Y=rp00432-
dc.description.naturepostprint-
dc.identifier.doi10.1089/neu.2018.6293-
dc.identifier.scopuseid_2-s2.0-85076061938-
dc.identifier.hkuros302702-
dc.identifier.volume36-
dc.identifier.issue24-
dc.identifier.spage3356-
dc.identifier.epage3362-
dc.publisher.placeUnited States-

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