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Article: The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer’s disease

TitleThe role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer’s disease
Authors
KeywordsSleep
Circadian rhythm
Alzheimer’s disease
Glymphatic
Dural lymphatics
Orexin
Oxidative stress
Melatonin
Stress granules
Issue Date2019
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yfrne
Citation
Frontiers in Neuroendocrinology, 2019, v. 54, article no. 100764 How to Cite?
AbstractEmerging evidence suggests that sleep deprivation (SD) and circadian rhythm disruption (CRD) may interact and increase the risk for the development of Alzheimer’s disease (AD). This review inspects different pathophysiological aspects of SD and CRD, and shows that the two may impair the glymphatic-vascular-lymphatic clearance of brain macromolecules (e.g., β-amyloid and microtubule associated protein tau), increase local brain oxidative stress and diminish circulatory melatonin levels. Lastly, this review looks into the potential association between sleep and circadian rhythm with stress granule formation, which might be a new mechanism along the AD pathogenic pathway. In summary, SD and CRD is likely to be associated with a positive risk in developing Alzheimer’s disease in humans.
Persistent Identifierhttp://hdl.handle.net/10722/276229
ISSN
2019 Impact Factor: 9.059
2015 SCImago Journal Rankings: 4.068
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, H-
dc.contributor.authorDunnett, S-
dc.contributor.authorHo, YS-
dc.contributor.authorChang, RCC-
dc.date.accessioned2019-09-10T02:58:37Z-
dc.date.available2019-09-10T02:58:37Z-
dc.date.issued2019-
dc.identifier.citationFrontiers in Neuroendocrinology, 2019, v. 54, article no. 100764-
dc.identifier.issn0091-3022-
dc.identifier.urihttp://hdl.handle.net/10722/276229-
dc.description.abstractEmerging evidence suggests that sleep deprivation (SD) and circadian rhythm disruption (CRD) may interact and increase the risk for the development of Alzheimer’s disease (AD). This review inspects different pathophysiological aspects of SD and CRD, and shows that the two may impair the glymphatic-vascular-lymphatic clearance of brain macromolecules (e.g., β-amyloid and microtubule associated protein tau), increase local brain oxidative stress and diminish circulatory melatonin levels. Lastly, this review looks into the potential association between sleep and circadian rhythm with stress granule formation, which might be a new mechanism along the AD pathogenic pathway. In summary, SD and CRD is likely to be associated with a positive risk in developing Alzheimer’s disease in humans.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yfrne-
dc.relation.ispartofFrontiers in Neuroendocrinology-
dc.subjectSleep-
dc.subjectCircadian rhythm-
dc.subjectAlzheimer’s disease-
dc.subjectGlymphatic-
dc.subjectDural lymphatics-
dc.subjectOrexin-
dc.subjectOxidative stress-
dc.subjectMelatonin-
dc.subjectStress granules-
dc.titleThe role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer’s disease-
dc.typeArticle-
dc.identifier.emailHo, YS: janiceys@hku.hk-
dc.identifier.emailChang, RCC: rccchang@hku.hk-
dc.identifier.authorityChang, RCC=rp00470-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.yfrne.2019.100764-
dc.identifier.pmid31102663-
dc.identifier.scopuseid_2-s2.0-85065925035-
dc.identifier.hkuros303900-
dc.identifier.volume54-
dc.identifier.spagearticle no. 100764-
dc.identifier.epagearticle no. 100764-
dc.identifier.isiWOS:000482544100004-
dc.publisher.placeUnited States-

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