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Article: Review: Revisiting the human cholinergic nucleus of the diagonal band of Broca

TitleReview: Revisiting the human cholinergic nucleus of the diagonal band of Broca
Authors
KeywordsAlzheimer's disease
Basal forebrain
Cholinergic system
Diagonal band of Broca
Lewy body dementia
Parkinson's disease
Issue Date2018
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2990
Citation
Neuropathology and Applied Neurobiology, 2018, v. 44 n. 7, p. 647-662 How to Cite?
AbstractAlthough the nucleus of the vertical limb of the diagonal band of Broca (nvlDBB) is the second largest cholinergic nucleus in the basal forebrain, after the nucleus basalis of Meynert, it has not generally been a focus for studies of neurodegenerative disorders. However, the nvlDBB has an important projection to the hippocampus and discrete lesions of the rostral basal forebrain have been shown to disrupt retrieval memory function, a major deficit seen in patients with Lewy body disorders. One reason for its neglect is that the anatomical boundaries of the nvlDBB are ill defined and this area of the brain is not part of routine diagnostic sampling protocols. We have reviewed the history and anatomy of the nvlDBB and now propose guidelines for distinguishing nvlDBB from other neighbouring cholinergic cell groups for standardizing future clinicopathological work. Thorough review of the literature regarding neurodegenerative conditions reveals inconsistent results in terms of cholinergic neuronal loss within the nvlDBB. This is likely to be due to the use of variable neuronal inclusion criteria and omission of cholinergic immunohistochemical markers. Extrapolating from those studies showing a significant nvlDBB neuronal loss in Lewy body dementia, we propose an anatomical and functional connection between the cholinergic component of the nvlDBB (Ch2) and the CA2 subfield in the hippocampus which may be especially vulnerable in Lewy body disorders.
Persistent Identifierhttp://hdl.handle.net/10722/276237
ISSN
2019 Impact Factor: 7.5
2015 SCImago Journal Rankings: 1.859
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, AKL-
dc.contributor.authorLim, EJ-
dc.contributor.authorAhmed, I-
dc.contributor.authorChang, RCC-
dc.contributor.authorPearce, RKB-
dc.contributor.authorGentleman, SM-
dc.date.accessioned2019-09-10T02:58:47Z-
dc.date.available2019-09-10T02:58:47Z-
dc.date.issued2018-
dc.identifier.citationNeuropathology and Applied Neurobiology, 2018, v. 44 n. 7, p. 647-662-
dc.identifier.issn0305-1846-
dc.identifier.urihttp://hdl.handle.net/10722/276237-
dc.description.abstractAlthough the nucleus of the vertical limb of the diagonal band of Broca (nvlDBB) is the second largest cholinergic nucleus in the basal forebrain, after the nucleus basalis of Meynert, it has not generally been a focus for studies of neurodegenerative disorders. However, the nvlDBB has an important projection to the hippocampus and discrete lesions of the rostral basal forebrain have been shown to disrupt retrieval memory function, a major deficit seen in patients with Lewy body disorders. One reason for its neglect is that the anatomical boundaries of the nvlDBB are ill defined and this area of the brain is not part of routine diagnostic sampling protocols. We have reviewed the history and anatomy of the nvlDBB and now propose guidelines for distinguishing nvlDBB from other neighbouring cholinergic cell groups for standardizing future clinicopathological work. Thorough review of the literature regarding neurodegenerative conditions reveals inconsistent results in terms of cholinergic neuronal loss within the nvlDBB. This is likely to be due to the use of variable neuronal inclusion criteria and omission of cholinergic immunohistochemical markers. Extrapolating from those studies showing a significant nvlDBB neuronal loss in Lewy body dementia, we propose an anatomical and functional connection between the cholinergic component of the nvlDBB (Ch2) and the CA2 subfield in the hippocampus which may be especially vulnerable in Lewy body disorders.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2990-
dc.relation.ispartofNeuropathology and Applied Neurobiology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAlzheimer's disease-
dc.subjectBasal forebrain-
dc.subjectCholinergic system-
dc.subjectDiagonal band of Broca-
dc.subjectLewy body dementia-
dc.subjectParkinson's disease-
dc.titleReview: Revisiting the human cholinergic nucleus of the diagonal band of Broca-
dc.typeArticle-
dc.identifier.emailChang, RCC: rccchang@hku.hk-
dc.identifier.authorityChang, RCC=rp00470-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1111/nan.12513-
dc.identifier.pmid30005126-
dc.identifier.pmcidPMC6282557-
dc.identifier.scopuseid_2-s2.0-85052402695-
dc.identifier.hkuros303976-
dc.identifier.volume44-
dc.identifier.issue7-
dc.identifier.spage647-
dc.identifier.epage662-
dc.identifier.isiWOS:000450597300001-
dc.publisher.placeUnited Kingdom-

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