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Article: Electrocoalescence of Liquid Marbles driven by Embedded Electrodes for Triggering Bioreactions

TitleElectrocoalescence of Liquid Marbles driven by Embedded Electrodes for Triggering Bioreactions
Authors
Issue Date2019
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/loc
Citation
Lab On a Chip, 2019, v. 19 n. 20, p. 3526-3534 How to Cite?
AbstractLiquid marbles need to be controlled precisely to benefit applications, for instance, as micro-reactors on digital microfluidics platforms for chemical and biological assays. In this work, a strategy is introduced to coalesce liquid marbles via electrostatics, where two contacting liquid marbles can coalesce when a sufficiently high voltage is applied to the embedded electrodes. With the understanding of the mechanism of coalescence through relating the electric stress and the restoring capillary pressure at the contacting interface, this method coalesces liquid marbles efficiently. When compared with the existing electrocoalescence method, our approach does not require immersion of the electrodes to trigger coalescence. We demonstrate this to exchange the medium for the culture of cell spheroids and to measure cell metabolic activity through a CCK-8 assay. The manipulation of liquid marbles driven by electrostatics creates new opportunities to conduct chemical reactions and biomedical assays in these novel micro-reactors.
Persistent Identifierhttp://hdl.handle.net/10722/277110
ISSN
2019 Impact Factor: 6.774
2015 SCImago Journal Rankings: 2.373

 

DC FieldValueLanguage
dc.contributor.authorZhang, Y-
dc.contributor.authorFu, X-
dc.contributor.authorGuo, W-
dc.contributor.authorDeng, Y-
dc.contributor.authorBinks, BP-
dc.contributor.authorShum, HC-
dc.date.accessioned2019-09-20T08:44:37Z-
dc.date.available2019-09-20T08:44:37Z-
dc.date.issued2019-
dc.identifier.citationLab On a Chip, 2019, v. 19 n. 20, p. 3526-3534-
dc.identifier.issn1473-0197-
dc.identifier.urihttp://hdl.handle.net/10722/277110-
dc.description.abstractLiquid marbles need to be controlled precisely to benefit applications, for instance, as micro-reactors on digital microfluidics platforms for chemical and biological assays. In this work, a strategy is introduced to coalesce liquid marbles via electrostatics, where two contacting liquid marbles can coalesce when a sufficiently high voltage is applied to the embedded electrodes. With the understanding of the mechanism of coalescence through relating the electric stress and the restoring capillary pressure at the contacting interface, this method coalesces liquid marbles efficiently. When compared with the existing electrocoalescence method, our approach does not require immersion of the electrodes to trigger coalescence. We demonstrate this to exchange the medium for the culture of cell spheroids and to measure cell metabolic activity through a CCK-8 assay. The manipulation of liquid marbles driven by electrostatics creates new opportunities to conduct chemical reactions and biomedical assays in these novel micro-reactors.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/loc-
dc.relation.ispartofLab On a Chip-
dc.titleElectrocoalescence of Liquid Marbles driven by Embedded Electrodes for Triggering Bioreactions-
dc.typeArticle-
dc.identifier.emailShum, HC: ashum@hku.hk-
dc.identifier.authorityShum, HC=rp01439-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/C9LC00722A-
dc.identifier.pmid31544191-
dc.identifier.scopuseid_2-s2.0-85073081915-
dc.identifier.hkuros305915-
dc.identifier.volume19-
dc.identifier.issue20-
dc.identifier.spage3526-
dc.identifier.epage3534-
dc.publisher.placeUnited Kingdom-

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