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Article: Systems pharmacology-based investigation of Sanwei Ganjiang Prescription: related mechanisms in liver injury

TitleSystems pharmacology-based investigation of Sanwei Ganjiang Prescription: related mechanisms in liver injury
Authors
KeywordsSystems pharmacology
Traditional Chinese Medicine
Sanwei Ganjiang Prescription
Liver injury
Oxidative stress
Issue Date2018
PublisherElsevier Ltd. The Journal's web site is located at http://www.sciencedirect.com/science/journal/18755364
Citation
Chinese Journal of Natural Medicines, 2018, v. 16 n. 10, p. 756-765 How to Cite?
AbstractLiver injury remains a significant global health problem and has a variety of causes, including oxidative stress (OS), inflammation, and apoptosis of liver cells. There is currently no curative therapy for this disorder. Sanwei Ganjiang Prescription (SWGJP), derived from traditional Chinese medicine (TCM), has shown its effectiveness in long-term liver damage therapy, although the underlying molecular mechanisms are still not fully understood. To explore the underlining mechanisms of action for SWGJP in liver injury from a holistic view, in the present study, a systems pharmacology approach was developed, which involved drug target identification and multilevel data integration analysis. Using a comprehensive systems approach, we identified 43 candidate compounds in SWGJP and 408 corresponding potential targets. We further deciphered the mechanisms of SWGJP in treating liver injury, including compound-target network analysis, target-function network analysis, and integrated pathways analysis. We deduced that SWGJP may protect hepatocytes through several functional modules involved in liver injury integrated-pathway, such as Nrf2-dependent anti-oxidative stress module. Notably, systems pharmacology provides an alternative way to investigate the complex action mode of TCM.
Persistent Identifierhttp://hdl.handle.net/10722/277137
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLuo, YX-
dc.contributor.authorWang, XY-
dc.contributor.authorHuang, YJ-
dc.contributor.authorFang, SH-
dc.contributor.authorWu, J-
dc.contributor.authorZhang, YB-
dc.contributor.authorXiong, TQ-
dc.contributor.authorYang, C-
dc.contributor.authorShen, JG-
dc.contributor.authorSang, CL-
dc.contributor.authorWang, Q-
dc.contributor.authorFang, JS-
dc.date.accessioned2019-09-20T08:45:19Z-
dc.date.available2019-09-20T08:45:19Z-
dc.date.issued2018-
dc.identifier.citationChinese Journal of Natural Medicines, 2018, v. 16 n. 10, p. 756-765-
dc.identifier.issn1875-5364-
dc.identifier.urihttp://hdl.handle.net/10722/277137-
dc.description.abstractLiver injury remains a significant global health problem and has a variety of causes, including oxidative stress (OS), inflammation, and apoptosis of liver cells. There is currently no curative therapy for this disorder. Sanwei Ganjiang Prescription (SWGJP), derived from traditional Chinese medicine (TCM), has shown its effectiveness in long-term liver damage therapy, although the underlying molecular mechanisms are still not fully understood. To explore the underlining mechanisms of action for SWGJP in liver injury from a holistic view, in the present study, a systems pharmacology approach was developed, which involved drug target identification and multilevel data integration analysis. Using a comprehensive systems approach, we identified 43 candidate compounds in SWGJP and 408 corresponding potential targets. We further deciphered the mechanisms of SWGJP in treating liver injury, including compound-target network analysis, target-function network analysis, and integrated pathways analysis. We deduced that SWGJP may protect hepatocytes through several functional modules involved in liver injury integrated-pathway, such as Nrf2-dependent anti-oxidative stress module. Notably, systems pharmacology provides an alternative way to investigate the complex action mode of TCM.-
dc.languageeng-
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.sciencedirect.com/science/journal/18755364-
dc.relation.ispartofChinese Journal of Natural Medicines-
dc.subjectSystems pharmacology-
dc.subjectTraditional Chinese Medicine-
dc.subjectSanwei Ganjiang Prescription-
dc.subjectLiver injury-
dc.subjectOxidative stress-
dc.titleSystems pharmacology-based investigation of Sanwei Ganjiang Prescription: related mechanisms in liver injury-
dc.typeArticle-
dc.identifier.emailShen, JG: shenjg@hku.hk-
dc.identifier.authorityShen, JG=rp00487-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1875-5364(18)30115-8-
dc.identifier.pmid30322609-
dc.identifier.scopuseid_2-s2.0-85054610096-
dc.identifier.hkuros305546-
dc.identifier.volume16-
dc.identifier.issue10-
dc.identifier.spage756-
dc.identifier.epage765-
dc.publisher.placeUnited Kingdom-

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