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Article: Potential Strategies in the Prevention of Nonsteroidal Anti-inflammatory Drugs-Associated Adverse Effects in the Lower Gastrointestinal Tract

TitlePotential Strategies in the Prevention of Nonsteroidal Anti-inflammatory Drugs-Associated Adverse Effects in the Lower Gastrointestinal Tract
Authors
GUO, CGLeung, jWK
KeywordsAnti-inflammatory agents
non-steroidal
Lower gastrointestinal bleeding
Protective agents
Issue Date2020
PublisherGut and Liver, Editorial Office. The Journal's web site is located at http://www.gutnliver.org/
Citation
Gut and Liver, 2020, v. 14 n. 2, p. 179-189 How to Cite?
DOI: http://dx.doi.org/10.5009/gnl19201
AbstractWith the increasing use of nonsteroidal anti-inflammatory drugs (NSAIDs), the incidence of lower gastrointestinal (GI) complications is expected to increase. However, unlike upper GI complications, the burden, pathogenesis, prevention and treatment of NSAID-associated lower GI complications remain unclear. To date, no cost-effective and safe protective agent has been developed that can completely prevent or treat NSAID-related lower GI injuries. Selective COX-2 inhibitors, misoprostol, intestinal microbiota modulation, and some mucoprotective agents have been reported to show protective effects on NSAID-induced lower GI injuries. This review aims to provide an overview of the current evidence on the prevention of NSAID-related lower GI injuries.
Persistent Identifierhttp://hdl.handle.net/10722/278219
ISSN
1976-2283
2021 Impact Factor: 4.321
2020 SCImago Journal Rankings: 1.331
ISI Accession Number ID
WOS:000520025800006

 

DC FieldValueLanguage
dc.contributor.authorGUO, CG-
dc.contributor.authorLeung, jWK-
dc.date.accessioned2019-10-04T08:09:47Z-
dc.date.available2019-10-04T08:09:47Z-
dc.date.issued2020-
dc.identifier.citationGut and Liver, 2020, v. 14 n. 2, p. 179-189-
dc.identifier.issn1976-2283-
dc.identifier.urihttp://hdl.handle.net/10722/278219-
dc.description.abstractWith the increasing use of nonsteroidal anti-inflammatory drugs (NSAIDs), the incidence of lower gastrointestinal (GI) complications is expected to increase. However, unlike upper GI complications, the burden, pathogenesis, prevention and treatment of NSAID-associated lower GI complications remain unclear. To date, no cost-effective and safe protective agent has been developed that can completely prevent or treat NSAID-related lower GI injuries. Selective COX-2 inhibitors, misoprostol, intestinal microbiota modulation, and some mucoprotective agents have been reported to show protective effects on NSAID-induced lower GI injuries. This review aims to provide an overview of the current evidence on the prevention of NSAID-related lower GI injuries.-
dc.languageeng-
dc.publisherGut and Liver, Editorial Office. The Journal's web site is located at http://www.gutnliver.org/-
dc.relation.ispartofGut and Liver-
dc.rightsGut and Liver. Copyright © Gut and Liver, Editorial Office.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAnti-inflammatory agents-
dc.subjectnon-steroidal-
dc.subjectLower gastrointestinal bleeding-
dc.subjectProtective agents-
dc.titlePotential Strategies in the Prevention of Nonsteroidal Anti-inflammatory Drugs-Associated Adverse Effects in the Lower Gastrointestinal Tract-
dc.typeArticle-
dc.identifier.emailLeung, jWK: waikleung@hku.hk-
dc.identifier.authorityLeung, jWK=rp01479-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5009/gnl19201-
dc.identifier.pmid31547642-
dc.identifier.scopuseid_2-s2.0-85081940033-
dc.identifier.hkuros307043-
dc.identifier.volume14-
dc.identifier.issue2-
dc.identifier.spage179-
dc.identifier.epage189-
dc.identifier.isiWOS:000520025800006-
dc.publisher.placeKorea, Republic of-
dc.identifier.issnl1976-2283-

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