Optogenetic fMRI of large-scale vestibular system and their cross-modal functions

Abstract

The vestibular system - pivotal for our sense of balance and orientation - integrates input from our other dominant senses, such as audition and vision, to create a multisensory percept. However, little is known regarding the extent of modulatory effects (if any) that the vestibular system exerts on the other sensory processing. Here, our report combined fMRI, optogenetics and sensory stimuli to provide large-scale brain-wide insights into the extent of cross-modal modulatory effects of the vestibular system on sensory processing. We reveal that vestibular nucleus optogenetic stimulation can modulate auditory and visual sensory processing at midbrain, thalamic and cortical regions.