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Article: MRI inflammation of facet and costovertebral joints is associated with restricted spinal mobility and worsened functional status

TitleMRI inflammation of facet and costovertebral joints is associated with restricted spinal mobility and worsened functional status
Authors
Keywordsspondyloarthritis
short tau inversion recovery (STIR) image
Bath Ankylosing Spondylitis Metrology Index
spinal mobility
inflammation
Issue Date2020
PublisherOxford University Press. The Journal's web site is located at http://rheumatology.oxfordjournals.org/
Citation
Rheumatology, 2020, Epub How to Cite?
AbstractObjective: To investigate the association of spinal inflammation on MRI in patients with various clinical, functional and radiological outcomes in patients with axial spondyloarthritis (SpA). Methods: Three hundred and ninety-seven participants with axial SpA and back pain were recruited from 10 rheumatology centres. Clinical, biochemical and radiological parameters were collected and participants underwent MRI of the spine. MRI features including inflammatory lesions of facet joints and costovertebral joints, corner inflammatory lesions, and spondylitis were assessed. BASFI, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Global Index, BASMI and modified Stoke Ankylosing Spondylitis Spinal Score were measured. Multivariate linear regression models were used to determine the associations between MRI parameters and various clinical, functional and radiological outcomes. Results: BASMI and BASFI correlated well with inflammatory features in spinal MRI. Multivariate analysis showed that lumbar facet joint inflammation was independently associated with BASMI (regression coefficient (β) = 0.12, P < 0.001), lumbar spinal flexion (β = 0.13, P = 0.00), lateral spinal flexion (β = 0.09, P = 0.04), tragus-to-wall distance (β = 0.16, P < 0.001) and BASFI (β = 0.14, P = 0.01). Costovertebral joint inflammation was also associated with BASMI (β = 0.08, P = 0.05). Conclusion: Inflammatory lesions of facet and costovertebral joints in MRI are associated with restriction in spinal mobility and functional impairment. These important yet commonly overlooked lesions should be reviewed in clinical practice in patients with SpA.
Persistent Identifierhttp://hdl.handle.net/10722/280368
ISSN
2017 Impact Factor: 5.245
2015 SCImago Journal Rankings: 1.449

 

DC FieldValueLanguage
dc.contributor.authorChui, ETF-
dc.contributor.authorTsang, HHL-
dc.contributor.authorLee, KH-
dc.contributor.authorLau, CS-
dc.contributor.authorWong, CH-
dc.contributor.authorChung, HY-
dc.date.accessioned2020-02-07T07:40:04Z-
dc.date.available2020-02-07T07:40:04Z-
dc.date.issued2020-
dc.identifier.citationRheumatology, 2020, Epub-
dc.identifier.issn1462-0324-
dc.identifier.urihttp://hdl.handle.net/10722/280368-
dc.description.abstractObjective: To investigate the association of spinal inflammation on MRI in patients with various clinical, functional and radiological outcomes in patients with axial spondyloarthritis (SpA). Methods: Three hundred and ninety-seven participants with axial SpA and back pain were recruited from 10 rheumatology centres. Clinical, biochemical and radiological parameters were collected and participants underwent MRI of the spine. MRI features including inflammatory lesions of facet joints and costovertebral joints, corner inflammatory lesions, and spondylitis were assessed. BASFI, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Global Index, BASMI and modified Stoke Ankylosing Spondylitis Spinal Score were measured. Multivariate linear regression models were used to determine the associations between MRI parameters and various clinical, functional and radiological outcomes. Results: BASMI and BASFI correlated well with inflammatory features in spinal MRI. Multivariate analysis showed that lumbar facet joint inflammation was independently associated with BASMI (regression coefficient (β) = 0.12, P < 0.001), lumbar spinal flexion (β = 0.13, P = 0.00), lateral spinal flexion (β = 0.09, P = 0.04), tragus-to-wall distance (β = 0.16, P < 0.001) and BASFI (β = 0.14, P = 0.01). Costovertebral joint inflammation was also associated with BASMI (β = 0.08, P = 0.05). Conclusion: Inflammatory lesions of facet and costovertebral joints in MRI are associated with restriction in spinal mobility and functional impairment. These important yet commonly overlooked lesions should be reviewed in clinical practice in patients with SpA.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://rheumatology.oxfordjournals.org/-
dc.relation.ispartofRheumatology-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.subjectspondyloarthritis-
dc.subjectshort tau inversion recovery (STIR) image-
dc.subjectBath Ankylosing Spondylitis Metrology Index-
dc.subjectspinal mobility-
dc.subjectinflammation-
dc.titleMRI inflammation of facet and costovertebral joints is associated with restricted spinal mobility and worsened functional status-
dc.typeArticle-
dc.identifier.emailLau, CS: cslau@hku.hk-
dc.identifier.emailChung, HY: jameschy@hku.hk-
dc.identifier.authorityLau, CS=rp01348-
dc.identifier.authorityChung, HY=rp02330-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/rheumatology/kez649-
dc.identifier.hkuros309103-
dc.identifier.volumeEpub-
dc.publisher.placeUnited Kingdom-

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