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Article: Determinants of physical, mental and social well-being: a longitudinal environment-wide association study

TitleDeterminants of physical, mental and social well-being: a longitudinal environment-wide association study
Authors
KeywordsEnvironment-wide association study
physical well-being
mental well-being
social well-being
depressive symptoms
Issue Date2020
PublisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/
Citation
International Journal of Epidemiology, 2020, v. 49 n. 2, p. 380-389 How to Cite?
AbstractBackground Although the World Health Organization (WHO) has defined health as a state of physical, mental and social well-being, public health strategies have primarily focused on one domain of well-being. We sought to systematically and simultaneously identify and validate associations of behavioural patterns, psychosocial factors, mental and physical health conditions, access to and utilization of health care and anthropometrics with physical, mental and social well-being. Methods: We conducted a longitudinal environment-wide association study (EWAS) with a training and testing set approach, accounting for multiple testing using a false discovery rate control. We used multivariate multilevel regression to examine the association of each exposure at wave 1 with the three outcomes at wave 2 in the Hong Kong FAMILY Cohort (n = 10 484). Results: Out of 194 exposures, we identified and validated 14, 5 and 5 exposures that were individually associated with physical, mental and social well-being, respectively. We discovered three factors, namely depressive symptoms, life satisfaction and happiness, that were simultaneously associated with the three domains that define health. Conclusions: These associations, if verified to be causal, could become intervention targets to holistically improve population health. Our findings provide empirical support for placing mental health at the forefront of the public health agenda, and also support recent calls to use life satisfaction and happiness to guide public policy.
Persistent Identifierhttp://hdl.handle.net/10722/281669
ISSN
2019 Impact Factor: 7.707
2015 SCImago Journal Rankings: 4.381

 

DC FieldValueLanguage
dc.contributor.authorNi, MY-
dc.contributor.authorYao, X-
dc.contributor.authorCheung, F-
dc.contributor.authorWu, JT-
dc.contributor.authorSchooling, CM-
dc.contributor.authorPang, H-
dc.contributor.authorLeung, GM-
dc.date.accessioned2020-03-22T04:18:03Z-
dc.date.available2020-03-22T04:18:03Z-
dc.date.issued2020-
dc.identifier.citationInternational Journal of Epidemiology, 2020, v. 49 n. 2, p. 380-389-
dc.identifier.issn0300-5771-
dc.identifier.urihttp://hdl.handle.net/10722/281669-
dc.description.abstractBackground Although the World Health Organization (WHO) has defined health as a state of physical, mental and social well-being, public health strategies have primarily focused on one domain of well-being. We sought to systematically and simultaneously identify and validate associations of behavioural patterns, psychosocial factors, mental and physical health conditions, access to and utilization of health care and anthropometrics with physical, mental and social well-being. Methods: We conducted a longitudinal environment-wide association study (EWAS) with a training and testing set approach, accounting for multiple testing using a false discovery rate control. We used multivariate multilevel regression to examine the association of each exposure at wave 1 with the three outcomes at wave 2 in the Hong Kong FAMILY Cohort (n = 10 484). Results: Out of 194 exposures, we identified and validated 14, 5 and 5 exposures that were individually associated with physical, mental and social well-being, respectively. We discovered three factors, namely depressive symptoms, life satisfaction and happiness, that were simultaneously associated with the three domains that define health. Conclusions: These associations, if verified to be causal, could become intervention targets to holistically improve population health. Our findings provide empirical support for placing mental health at the forefront of the public health agenda, and also support recent calls to use life satisfaction and happiness to guide public policy.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/-
dc.relation.ispartofInternational Journal of Epidemiology-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.subjectEnvironment-wide association study-
dc.subjectphysical well-being-
dc.subjectmental well-being-
dc.subjectsocial well-being-
dc.subjectdepressive symptoms-
dc.titleDeterminants of physical, mental and social well-being: a longitudinal environment-wide association study-
dc.typeArticle-
dc.identifier.emailNi, MY: nimy@hku.hk-
dc.identifier.emailYao, X: irisyxx@hku.hk-
dc.identifier.emailCheung, F: felixckc@hku.hk-
dc.identifier.emailWu, JT: joewu@hku.hk-
dc.identifier.emailSchooling, CM: cms1@hkucc.hku.hk-
dc.identifier.emailPang, H: herbpang@hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.authorityNi, MY=rp01639-
dc.identifier.authorityCheung, F=rp02275-
dc.identifier.authorityWu, JT=rp00517-
dc.identifier.authoritySchooling, CM=rp00504-
dc.identifier.authorityPang, H=rp01857-
dc.identifier.authorityLeung, GM=rp00460-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/ije/dyz238-
dc.identifier.pmid31872233-
dc.identifier.scopuseid_2-s2.0-85078129383-
dc.identifier.hkuros309483-
dc.identifier.volume49-
dc.identifier.issue2-
dc.identifier.spage380-
dc.identifier.epage389-
dc.publisher.placeUnited Kingdom-

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