File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Multiple Functions of B Cells in the Pathogenesis of Systemic Lupus Erythematosus

TitleMultiple Functions of B Cells in the Pathogenesis of Systemic Lupus Erythematosus
Authors
Keywordssystemic lupus erythematosus (SLE)
autoreactive B cells
age-associated B cells (ABCs)
regulatory B cells (Bregs)
Issue Date2019
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms
Citation
International Journal of Molecular Sciences, 2019, v. 20 n. 23, article no. 6021 How to Cite?
AbstractSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by excessive autoantibody production and multi-organ involvement. Although the etiology of SLE still remains unclear, recent studies have characterized several pathogenic B cell subsets and regulatory B cell subsets involved in the pathogenesis of SLE. Among pathogenic B cell subsets, age-associated B cells (ABCs) are a newly identified subset of autoreactive B cells with T-bet-dependent transcriptional programs and unique functional features in SLE. Accumulation of T-bet+ CD11c+ ABCs has been observed in SLE patients and lupus mouse models. In addition, innate-like B cells with the autoreactive B cell receptor (BCR) expression and long-lived plasma cells with persistent autoantibody production contribute to the development of SLE. Moreover, several regulatory B cell subsets with immune suppressive functions have been identified, while the impaired inhibitory effects of regulatory B cells have been indicated in SLE. Thus, further elucidation on the functional features of B cell subsets will provide new insights in understanding lupus pathogenesis and lead to novel therapeutic interventions in the treatment of SLE.
Persistent Identifierhttp://hdl.handle.net/10722/281908
ISSN
2011 Impact Factor: 2.598
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, K-
dc.contributor.authorDu, W-
dc.contributor.authorWang, X-
dc.contributor.authorYuan, S-
dc.contributor.authorCai, X-
dc.contributor.authorLiu, D-
dc.contributor.authorLi, J-
dc.contributor.authorLu, L-
dc.date.accessioned2020-04-03T07:23:29Z-
dc.date.available2020-04-03T07:23:29Z-
dc.date.issued2019-
dc.identifier.citationInternational Journal of Molecular Sciences, 2019, v. 20 n. 23, article no. 6021-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10722/281908-
dc.description.abstractSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by excessive autoantibody production and multi-organ involvement. Although the etiology of SLE still remains unclear, recent studies have characterized several pathogenic B cell subsets and regulatory B cell subsets involved in the pathogenesis of SLE. Among pathogenic B cell subsets, age-associated B cells (ABCs) are a newly identified subset of autoreactive B cells with T-bet-dependent transcriptional programs and unique functional features in SLE. Accumulation of T-bet+ CD11c+ ABCs has been observed in SLE patients and lupus mouse models. In addition, innate-like B cells with the autoreactive B cell receptor (BCR) expression and long-lived plasma cells with persistent autoantibody production contribute to the development of SLE. Moreover, several regulatory B cell subsets with immune suppressive functions have been identified, while the impaired inhibitory effects of regulatory B cells have been indicated in SLE. Thus, further elucidation on the functional features of B cell subsets will provide new insights in understanding lupus pathogenesis and lead to novel therapeutic interventions in the treatment of SLE.-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectsystemic lupus erythematosus (SLE)-
dc.subjectautoreactive B cells-
dc.subjectage-associated B cells (ABCs)-
dc.subjectregulatory B cells (Bregs)-
dc.titleMultiple Functions of B Cells in the Pathogenesis of Systemic Lupus Erythematosus-
dc.typeArticle-
dc.identifier.emailMa, K: kongyang@hku.hk-
dc.identifier.emailWang, X: xiaohuiwang@hku.hk-
dc.identifier.emailLu, L: liweilu@hku.hk-
dc.identifier.authorityWang, X=rp02664-
dc.identifier.authorityLu, L=rp00477-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ijms20236021-
dc.identifier.pmid31795353-
dc.identifier.pmcidPMC6929160-
dc.identifier.scopuseid_2-s2.0-85075879133-
dc.identifier.hkuros309591-
dc.identifier.volume20-
dc.identifier.issue23-
dc.identifier.spagearticle no. 6021-
dc.identifier.epagearticle no. 6021-
dc.identifier.isiWOS:000504428300203-
dc.publisher.placeSwitzerland-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats