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Article: Higher Dementia Incidence in Older Adults with Poor Visual Acuity

TitleHigher Dementia Incidence in Older Adults with Poor Visual Acuity
Authors
Editors
Editor(s):Magaziner, J
KeywordsPoor vision
Visual impairment
Cognitive impairment
Issue Date2020
PublisherOxford University Press. The Journal's web site is located at https://academic.oup.com/biomedgerontology
Citation
Journals Of Gerontology Series A: Biological Sciences And Medical Sciences, 2020, Epub 2020-02-11 How to Cite?
AbstractBackground: Longitudinal evidence of poor visual acuity associating with higher risk of incident dementia is mixed. This study aimed to examine if poor visual acuity was associated with higher dementia incidence in a large community cohort of older adults, independent of the possible biases relating to misclassification error, reverse causality, and confounding effects due to health problems and behaviors. Methods: A total of 15,576 community-living older adults without dementia at baseline were followed for 6 years to the outcome of incident dementia, which was diagnosed according to the ICD-10 or a Clinical Dementia Rating of 1 to 3. Visual acuity was assessed using the Snellen’s chart at baseline and follow-up. Important variables including demographics (age, sex, education, and socioeconomic status), physical and psychiatric comorbidities (cardiovascular risks, ophthalmological conditions, hearing impairment, poor mobility, and depression), and lifestyle behaviors (smoking, diet, physical, intellectual, and social activities) were also assessed. Results: Over 68,904 person-years of follow-up, 1,349 participants developed dementia. Poorer visual acuity at baseline was associated with higher dementia incidence in 6 years, even after adjusting for demographics, health problems, and lifestyle behaviors, and excluding those who developed dementia within 3 years after baseline. Compared with normal vision, the hazard ratio of dementia was 1.19 (p = .31), 2.09 (p < .001), and 8.66 (p < .001) for mild, moderate, and severe visual impairment, respectively. Conclusions: Moderate-to-severe visual impairment could be a potential predictor and possibly a risk factor for dementia. From a clinical perspective, older adults with poor visual acuity might warrant further risk assessment for dementia.
Persistent Identifierhttp://hdl.handle.net/10722/282010
ISSN
2019 Impact Factor: 5.236
2015 SCImago Journal Rankings: 2.675

 

DC FieldValueLanguage
dc.contributor.authorLee, ATC-
dc.contributor.authorRichards, M-
dc.contributor.authorChan, WC-
dc.contributor.authorChiu, HFK-
dc.contributor.authorLee, RSY-
dc.contributor.authorLam, LCW-
dc.contributor.editorMagaziner, J-
dc.date.accessioned2020-04-19T03:34:05Z-
dc.date.available2020-04-19T03:34:05Z-
dc.date.issued2020-
dc.identifier.citationJournals Of Gerontology Series A: Biological Sciences And Medical Sciences, 2020, Epub 2020-02-11-
dc.identifier.issn1079-5006-
dc.identifier.urihttp://hdl.handle.net/10722/282010-
dc.description.abstractBackground: Longitudinal evidence of poor visual acuity associating with higher risk of incident dementia is mixed. This study aimed to examine if poor visual acuity was associated with higher dementia incidence in a large community cohort of older adults, independent of the possible biases relating to misclassification error, reverse causality, and confounding effects due to health problems and behaviors. Methods: A total of 15,576 community-living older adults without dementia at baseline were followed for 6 years to the outcome of incident dementia, which was diagnosed according to the ICD-10 or a Clinical Dementia Rating of 1 to 3. Visual acuity was assessed using the Snellen’s chart at baseline and follow-up. Important variables including demographics (age, sex, education, and socioeconomic status), physical and psychiatric comorbidities (cardiovascular risks, ophthalmological conditions, hearing impairment, poor mobility, and depression), and lifestyle behaviors (smoking, diet, physical, intellectual, and social activities) were also assessed. Results: Over 68,904 person-years of follow-up, 1,349 participants developed dementia. Poorer visual acuity at baseline was associated with higher dementia incidence in 6 years, even after adjusting for demographics, health problems, and lifestyle behaviors, and excluding those who developed dementia within 3 years after baseline. Compared with normal vision, the hazard ratio of dementia was 1.19 (p = .31), 2.09 (p < .001), and 8.66 (p < .001) for mild, moderate, and severe visual impairment, respectively. Conclusions: Moderate-to-severe visual impairment could be a potential predictor and possibly a risk factor for dementia. From a clinical perspective, older adults with poor visual acuity might warrant further risk assessment for dementia.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at https://academic.oup.com/biomedgerontology-
dc.relation.ispartofJournals Of Gerontology Series A: Biological Sciences And Medical Sciences, 2020-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectPoor vision-
dc.subjectVisual impairment-
dc.subjectCognitive impairment-
dc.titleHigher Dementia Incidence in Older Adults with Poor Visual Acuity-
dc.typeArticle-
dc.identifier.emailChan, WC: waicchan@hku.hk-
dc.identifier.authorityChan, WC=rp01687-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/gerona/glaa036-
dc.identifier.scopuseid_2-s2.0-85090447267-
dc.identifier.hkuros309756-
dc.identifier.volumeEpub 2020-02-11-
dc.publisher.placeUnited States-

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