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Article: Temporal dynamics in viral shedding and transmissibility of COVID-19

TitleTemporal dynamics in viral shedding and transmissibility of COVID-19
Authors
He, XLau, EHYWu, PDeng, XWang, JHao, XLau, YCWong, YTGuan, YTan, XMo, XChen, YLiao, BChen, WHu, FZhang, QZhong, MWu, YZhao, LZhang, FCowling, BJLi, FLeung, GM
Keywordscontrolled study
coronavirus disease 2019
disease control
disease severity
disease transmission
Issue Date2020
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nm
Citation
Nature Medicine, 2020, v. 26 n. 5, p. 672-675 How to Cite?
DOI: http://dx.doi.org/10.1038/s41591-020-0869-5
AbstractWe report temporal patterns of viral shedding in 94 patients with laboratory-confirmed COVID-19 and modeled COVID-19 infectiousness profiles from a separate sample of 77 infector–infectee transmission pairs. We observed the highest viral load in throat swabs at the time of symptom onset, and inferred that infectiousness peaked on or before symptom onset. We estimated that 44% (95% confidence interval, 25–69%) of secondary cases were infected during the index cases’ presymptomatic stage, in settings with substantial household clustering, active case finding and quarantine outside the home. Disease control measures should be adjusted to account for probable substantial presymptomatic transmission.
DescriptionHybrid open access
Persistent Identifierhttp://hdl.handle.net/10722/282830
ISSN
1078-8956
2021 Impact Factor: 87.241
2020 SCImago Journal Rankings: 19.536
ISI Accession Number ID
WOS:000526227300001
Errata
http://dx.doi.org/10.1038/s41591-020-1016-z
eid_2-s2.0-85089100644

 

DC FieldValueLanguage
dc.contributor.authorHe, X-
dc.contributor.authorLau, EHY-
dc.contributor.authorWu, P-
dc.contributor.authorDeng, X-
dc.contributor.authorWang, J-
dc.contributor.authorHao, X-
dc.contributor.authorLau, YC-
dc.contributor.authorWong, YT-
dc.contributor.authorGuan, Y-
dc.contributor.authorTan, X-
dc.contributor.authorMo, X-
dc.contributor.authorChen, Y-
dc.contributor.authorLiao, B-
dc.contributor.authorChen, W-
dc.contributor.authorHu, F-
dc.contributor.authorZhang, Q-
dc.contributor.authorZhong, M-
dc.contributor.authorWu, Y-
dc.contributor.authorZhao, L-
dc.contributor.authorZhang, F-
dc.contributor.authorCowling, BJ-
dc.contributor.authorLi, F-
dc.contributor.authorLeung, GM-
dc.date.accessioned2020-06-05T06:22:03Z-
dc.date.available2020-06-05T06:22:03Z-
dc.date.issued2020-
dc.identifier.citationNature Medicine, 2020, v. 26 n. 5, p. 672-675-
dc.identifier.issn1078-8956-
dc.identifier.urihttp://hdl.handle.net/10722/282830-
dc.descriptionHybrid open access-
dc.description.abstractWe report temporal patterns of viral shedding in 94 patients with laboratory-confirmed COVID-19 and modeled COVID-19 infectiousness profiles from a separate sample of 77 infector–infectee transmission pairs. We observed the highest viral load in throat swabs at the time of symptom onset, and inferred that infectiousness peaked on or before symptom onset. We estimated that 44% (95% confidence interval, 25–69%) of secondary cases were infected during the index cases’ presymptomatic stage, in settings with substantial household clustering, active case finding and quarantine outside the home. Disease control measures should be adjusted to account for probable substantial presymptomatic transmission.-
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nm-
dc.relation.ispartofNature Medicine-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.subjectcontrolled study-
dc.subjectcoronavirus disease 2019-
dc.subjectdisease control-
dc.subjectdisease severity-
dc.subjectdisease transmission-
dc.titleTemporal dynamics in viral shedding and transmissibility of COVID-19-
dc.typeArticle-
dc.identifier.emailLau, EHY: ehylau@hku.hk-
dc.identifier.emailWu, P: pengwu@hku.hk-
dc.identifier.emailHao, X: haoxx@hku.hk-
dc.identifier.emailWong, YT: wongytj@hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.authorityLau, EHY=rp01349-
dc.identifier.authorityWu, P=rp02025-
dc.identifier.authorityCowling, BJ=rp01326-
dc.identifier.authorityLeung, GM=rp00460-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/s41591-020-0869-5-
dc.identifier.pmid32296168-
dc.identifier.scopuseid_2-s2.0-85083513005-
dc.identifier.hkuros310170-
dc.identifier.hkuros320771-
dc.identifier.volume26-
dc.identifier.issue5-
dc.identifier.spage672-
dc.identifier.epage675-
dc.identifier.isiWOS:000526227300001-
dc.publisher.placeUnited States-
dc.relation.erratumdoi:10.1038/s41591-020-1016-z-
dc.relation.erratumeid:eid_2-s2.0-85089100644-
dc.identifier.issnl1078-8956-

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