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Article: Maternal antibodies against influenza in cord blood and protection against laboratory-confirmed influenza in infants

TitleMaternal antibodies against influenza in cord blood and protection against laboratory-confirmed influenza in infants
Authors
Keywordsinfluenza
maternal
antibodies
infant
protection
Issue Date2019
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
Citation
Clinical Infectious Diseases, 2019, Epub 2019-10-29 How to Cite?
AbstractBackground: Studies that correlate maternal antibodies with protection from influenza A or B virus infection in young infants in areas with prolonged influenza circulation are lacking. Methods: We conducted a prospective, observational study to evaluate the effects of maternally transferred antibodies against influenza A and B viruses against laboratory-confirmed influenza in a cohort born over 24 months. Cord blood samples were retrieved at birth and infants were actively followed for the first 6 months of life. Nasal swabs were collected and tested for influenza A and B by reverse transcriptase–polymerase chain reaction whenever an illness episode was identified. Cord blood samples were tested by the hemagglutination inhibition (HAI) assay to viruses that circulated during the follow-up period. Results: 1162 infants were born to 1140 recruited women: 1092 (94%) infants completed 6 months of follow-up. Proportions of cord blood with HAI antibody titers ≥40 against A(H1N1), A(H3N2), B/Victoria, and B/Yamagata were 31%, 24%, 31%, and 54%, respectively. Only 4% of women had maternal influenza vaccination. Cord blood antigen-specific HAI titers ≥40 were found to correlate with protection from infection only for influenza B/Yamagata. No influenza B virus infection occurred in infants ≤60 days old. Proportional hazards analysis showed that a cord blood HAI titer of 40 was associated with 83% (95% confidence interval, 44–95%) reduction in the risk of influenza B/Yamagata infections compared with a cord blood titer <10. Conclusions: We documented that maternal immunity against influenza B/Yamagata was conferred to infants within the first 6 months of life.
Persistent Identifierhttp://hdl.handle.net/10722/282831
ISSN
2019 Impact Factor: 8.313
2015 SCImago Journal Rankings: 4.742

 

DC FieldValueLanguage
dc.contributor.authorCowling, BJ-
dc.contributor.authorPerera, RAPM-
dc.contributor.authorFang, VJ-
dc.contributor.authorChu, DKW-
dc.contributor.authorHui, APW-
dc.contributor.authorYeung, APC-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorWong, WHS-
dc.contributor.authorChan, ELY-
dc.contributor.authorChiu, SS-
dc.date.accessioned2020-06-05T06:22:04Z-
dc.date.available2020-06-05T06:22:04Z-
dc.date.issued2019-
dc.identifier.citationClinical Infectious Diseases, 2019, Epub 2019-10-29-
dc.identifier.issn1058-4838-
dc.identifier.urihttp://hdl.handle.net/10722/282831-
dc.description.abstractBackground: Studies that correlate maternal antibodies with protection from influenza A or B virus infection in young infants in areas with prolonged influenza circulation are lacking. Methods: We conducted a prospective, observational study to evaluate the effects of maternally transferred antibodies against influenza A and B viruses against laboratory-confirmed influenza in a cohort born over 24 months. Cord blood samples were retrieved at birth and infants were actively followed for the first 6 months of life. Nasal swabs were collected and tested for influenza A and B by reverse transcriptase–polymerase chain reaction whenever an illness episode was identified. Cord blood samples were tested by the hemagglutination inhibition (HAI) assay to viruses that circulated during the follow-up period. Results: 1162 infants were born to 1140 recruited women: 1092 (94%) infants completed 6 months of follow-up. Proportions of cord blood with HAI antibody titers ≥40 against A(H1N1), A(H3N2), B/Victoria, and B/Yamagata were 31%, 24%, 31%, and 54%, respectively. Only 4% of women had maternal influenza vaccination. Cord blood antigen-specific HAI titers ≥40 were found to correlate with protection from infection only for influenza B/Yamagata. No influenza B virus infection occurred in infants ≤60 days old. Proportional hazards analysis showed that a cord blood HAI titer of 40 was associated with 83% (95% confidence interval, 44–95%) reduction in the risk of influenza B/Yamagata infections compared with a cord blood titer <10. Conclusions: We documented that maternal immunity against influenza B/Yamagata was conferred to infants within the first 6 months of life.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/-
dc.relation.ispartofClinical Infectious Diseases-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.subjectinfluenza-
dc.subjectmaternal-
dc.subjectantibodies-
dc.subjectinfant-
dc.subjectprotection-
dc.titleMaternal antibodies against influenza in cord blood and protection against laboratory-confirmed influenza in infants-
dc.typeArticle-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.emailPerera, RAPM: mahenp@hku.hk-
dc.identifier.emailChu, DKW: dkwchu@hku.hk-
dc.identifier.emailHui, APW: apwhui@hkucc.hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailWong, WHS: whswong@hku.hk-
dc.identifier.emailChan, ELY: laiyin@hkucc.hku.hk-
dc.identifier.emailChiu, SS: ssschiu@hku.hk-
dc.identifier.authorityCowling, BJ=rp01326-
dc.identifier.authorityPerera, RAPM=rp02500-
dc.identifier.authorityChu, DKW=rp02512-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityChiu, SS=rp00421-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/cid/ciz1058-
dc.identifier.pmid31665236-
dc.identifier.hkuros310171-
dc.identifier.volumeEpub 2019-10-29-
dc.publisher.placeUnited States-

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