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Article: Hierarchical ZnO Nanotube/Graphene Oxide Nanostructures Endow Pure Zn Implant with Synergistic Bactericidal Activity and Osteogenicity

TitleHierarchical ZnO Nanotube/Graphene Oxide Nanostructures Endow Pure Zn Implant with Synergistic Bactericidal Activity and Osteogenicity
Authors
KeywordsCoating materials
Electrochemistry
Oxides
Biomaterials
Oxidation
Issue Date2019
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/iecr
Citation
Industrial & Engineering Chemistry Research, 2019, v. 58 n. 42, p. 19377-19385 How to Cite?
AbstractZinc (Zn) material has recently become a rising biodegradable metal in orthopedic applications owing to its critical physiological functions and degradation characteristics. However, the unsatisfactory cytocompatibility due to the locally high concentration of Zn ions liberated during degradation accompanied with a lack of antibacterial property and osteogenesis severely obstruct the clinical adoption of pure Zn implants. To address these challenges, we construct hierarchical ZnO nanotube/graphene oxide (GO) nanostructures (GO-An-Zn) on the pure Zn substrates via anodic oxidation followed by silk fibroin/GO self-assembly in the present study. The resultant surface displays superior bacteria-killing performances against both Gram-negative and Gram-positive bacteria. Moreover, osteoblasts on the dexamethasone (Dex)-laden hierarchical microstructured/nanostructured Zn (GO-Dex-An-Zn) show the enhanced cell compatibility and osteogenicity, outperforming these on pure Zn substrates. It is mainly attributed to the synergistic delivery of Zn ions and Dex from bulk materials during degradation, forming a favorable microenvironment for cell survival and bone tissue remodeling. Accordingly, such work provides a novel solution to simultaneously improve the bactericidal activity and osteogenic potential of Zn-based biomaterials, bode well for their orthopedic use.
Persistent Identifierhttp://hdl.handle.net/10722/282852
ISSN
2019 Impact Factor: 3.573
2015 SCImago Journal Rankings: 0.976
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLyu, H-
dc.contributor.authorHe, Z-
dc.contributor.authorChan, YK-
dc.contributor.authorHe, X-
dc.contributor.authorYu, Y-
dc.contributor.authorDeng, Y-
dc.date.accessioned2020-06-05T06:22:19Z-
dc.date.available2020-06-05T06:22:19Z-
dc.date.issued2019-
dc.identifier.citationIndustrial & Engineering Chemistry Research, 2019, v. 58 n. 42, p. 19377-19385-
dc.identifier.issn0888-5885-
dc.identifier.urihttp://hdl.handle.net/10722/282852-
dc.description.abstractZinc (Zn) material has recently become a rising biodegradable metal in orthopedic applications owing to its critical physiological functions and degradation characteristics. However, the unsatisfactory cytocompatibility due to the locally high concentration of Zn ions liberated during degradation accompanied with a lack of antibacterial property and osteogenesis severely obstruct the clinical adoption of pure Zn implants. To address these challenges, we construct hierarchical ZnO nanotube/graphene oxide (GO) nanostructures (GO-An-Zn) on the pure Zn substrates via anodic oxidation followed by silk fibroin/GO self-assembly in the present study. The resultant surface displays superior bacteria-killing performances against both Gram-negative and Gram-positive bacteria. Moreover, osteoblasts on the dexamethasone (Dex)-laden hierarchical microstructured/nanostructured Zn (GO-Dex-An-Zn) show the enhanced cell compatibility and osteogenicity, outperforming these on pure Zn substrates. It is mainly attributed to the synergistic delivery of Zn ions and Dex from bulk materials during degradation, forming a favorable microenvironment for cell survival and bone tissue remodeling. Accordingly, such work provides a novel solution to simultaneously improve the bactericidal activity and osteogenic potential of Zn-based biomaterials, bode well for their orthopedic use.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/iecr-
dc.relation.ispartofIndustrial & Engineering Chemistry Research-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.subjectCoating materials-
dc.subjectElectrochemistry-
dc.subjectOxides-
dc.subjectBiomaterials-
dc.subjectOxidation-
dc.titleHierarchical ZnO Nanotube/Graphene Oxide Nanostructures Endow Pure Zn Implant with Synergistic Bactericidal Activity and Osteogenicity-
dc.typeArticle-
dc.identifier.emailChan, YK: josephyk@connect.hku.hk-
dc.identifier.authorityChan, YK=rp02536-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.iecr.9b02986-
dc.identifier.scopuseid_2-s2.0-85073056752-
dc.identifier.hkuros310042-
dc.identifier.volume58-
dc.identifier.issue42-
dc.identifier.spage19377-
dc.identifier.epage19385-
dc.identifier.isiWOS:000500349200005-
dc.publisher.placeUnited States-
dc.identifier.issnl0888-5885-

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