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Article: A Systematic Review of Emerging Therapeutic Strategies in the Management of Chemical Injuries of the Ocular Surface

TitleA Systematic Review of Emerging Therapeutic Strategies in the Management of Chemical Injuries of the Ocular Surface
Authors
KeywordsCornea
Eye
Epithelium
Management
Therapy
Issue Date2020
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.claojournal.org/
Citation
Eye & Contact Lens, 2020, Epub 2020-05-22 How to Cite?
AbstractObjectives: To evaluate recent in vivo studies on emerging therapies for managing corneal epithelial injuries. Methods: The search was conducted on PubMed for articles published between January 2015 and September 2019 and in English language. Results: Thirty studies were identified for evaluation, including those on mesenchymal stem cells, amniotic membrane-derived therapies, endogenous peptides and their inhibitors, as well as hydrogel therapies. Intermediate to strong levels of evidence are presented regarding the use of these strategies on chemically injured cornea, including their effects on healing of corneal epithelial defect, anti-inflammatory properties, prevention of corneal neovascularization, as well as restoration of anatomy and functions of the anterior eye, although clinical trials are needed to determine the safety and efficacy of these strategies on humans. Conclusion: Recent advances and understanding in various novel therapeutic methods for corneal epithelial chemical injuries should provide potential alternatives to current standard treatment regimens and help reduce risks of complications, hence improve patient outcomes.
Persistent Identifierhttp://hdl.handle.net/10722/282865
ISSN
2019 Impact Factor: 1.521
2015 SCImago Journal Rankings: 0.580
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPoon, SHL-
dc.contributor.authorWong, WHL-
dc.contributor.authorBU, Y-
dc.contributor.authorLo, ACY-
dc.contributor.authorJhanji, V-
dc.contributor.authorChan, YK-
dc.contributor.authorShih, KC-
dc.date.accessioned2020-06-05T06:22:26Z-
dc.date.available2020-06-05T06:22:26Z-
dc.date.issued2020-
dc.identifier.citationEye & Contact Lens, 2020, Epub 2020-05-22-
dc.identifier.issn1542-2321-
dc.identifier.urihttp://hdl.handle.net/10722/282865-
dc.description.abstractObjectives: To evaluate recent in vivo studies on emerging therapies for managing corneal epithelial injuries. Methods: The search was conducted on PubMed for articles published between January 2015 and September 2019 and in English language. Results: Thirty studies were identified for evaluation, including those on mesenchymal stem cells, amniotic membrane-derived therapies, endogenous peptides and their inhibitors, as well as hydrogel therapies. Intermediate to strong levels of evidence are presented regarding the use of these strategies on chemically injured cornea, including their effects on healing of corneal epithelial defect, anti-inflammatory properties, prevention of corneal neovascularization, as well as restoration of anatomy and functions of the anterior eye, although clinical trials are needed to determine the safety and efficacy of these strategies on humans. Conclusion: Recent advances and understanding in various novel therapeutic methods for corneal epithelial chemical injuries should provide potential alternatives to current standard treatment regimens and help reduce risks of complications, hence improve patient outcomes.-
dc.languageeng-
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.claojournal.org/-
dc.relation.ispartofEye & Contact Lens-
dc.subjectCornea-
dc.subjectEye-
dc.subjectEpithelium-
dc.subjectManagement-
dc.subjectTherapy-
dc.titleA Systematic Review of Emerging Therapeutic Strategies in the Management of Chemical Injuries of the Ocular Surface-
dc.typeArticle-
dc.identifier.emailLo, ACY: amylo@hku.hk-
dc.identifier.emailChan, YK: josephyk@connect.hku.hk-
dc.identifier.emailShih, KC: kcshih@hku.hk-
dc.identifier.authorityLo, ACY=rp00425-
dc.identifier.authorityChan, YK=rp02536-
dc.identifier.authorityShih, KC=rp01374-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/ICL.0000000000000715-
dc.identifier.pmid32452924-
dc.identifier.scopuseid_2-s2.0-85094932844-
dc.identifier.hkuros310223-
dc.identifier.hkuros310050-
dc.identifier.volumeEpub 2020-05-22-
dc.identifier.isiWOS:000587796700006-
dc.publisher.placeUnited States-

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