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Article: Diurnal Cortisol Slope Mediates the Association Between Affect and Memory Retrieval in Older Adults With Mild Cognitive Impairment: A Path-Analytical Study

TitleDiurnal Cortisol Slope Mediates the Association Between Affect and Memory Retrieval in Older Adults With Mild Cognitive Impairment: A Path-Analytical Study
Authors
Keywordsdiurnal cortisol rhythm
early dementia
episodic memory
mild cognitive impairment
subjective mood
Issue Date2020
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/aging_neuroscience
Citation
Frontiers in Aging Neuroscience, 2020, v. 12, p. article no. 35 How to Cite?
AbstractBackground Memory deficits are linked to dysfunctional HPA axis activity and negative affect in older adults. This study evaluated the mediating effect of the diurnal cortisol pattern on the relationship between affect and memory in older people with mild cognitive impairment (MCI). Methods This longitudinal study recruited 189 Chinese older adults with MCI from elderly centers in Hong Kong. The participants completed assessments of affect, salivary cortisol, and digit spans at baseline; neurocognitive assessments on verbal fluency, memory retrieval, and digit spans at 6-month follow-up; and instrumental activities of daily living (IADL) at 1-year follow-up. Structural equation modeling examined the direct and indirect effects of negative affect on memory and IADL via diurnal cortisol pattern. Results Controlling for covariates, negative affect significantly predicted flattened diurnal cortisol slopes (beta = 0.17, p < 0.05) but not memory or IADL (p = 0.23 - 0.91) directly. Diurnal cortisol slopes negatively predicted memory retrieval (beta = -0.20, p < 0.05), which in turn positively predicted IADL (beta = 0.22, p < 0.01). The indirect effect from negative affect to IADL via cortisol slope and memory retrieval was significant and negative (alpha beta gamma = -0.05, 95% bootstrapped CI = -0.248 to -0.001). Discussion The present study established certain temporal linkages among affect and cortisol slopes at baseline, memory retrieval at 6 months, and functional decline 1 year later in older adults with MCI. Flattened diurnal cortisol slopes might mediate the detrimental effects of negative affect on memory retrieval and functioning across 1 year.
Persistent Identifierhttp://hdl.handle.net/10722/282944
ISSN
2019 Impact Factor: 4.362
2015 SCImago Journal Rankings: 1.808
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, RTH-
dc.contributor.authorFong, TCT-
dc.contributor.authorYau, JCY-
dc.contributor.authorChan, WC-
dc.contributor.authorKwan, JSK-
dc.contributor.authorChiu, PKC-
dc.contributor.authorLam, LCW-
dc.date.accessioned2020-06-05T06:23:21Z-
dc.date.available2020-06-05T06:23:21Z-
dc.date.issued2020-
dc.identifier.citationFrontiers in Aging Neuroscience, 2020, v. 12, p. article no. 35-
dc.identifier.issn1663-4365-
dc.identifier.urihttp://hdl.handle.net/10722/282944-
dc.description.abstractBackground Memory deficits are linked to dysfunctional HPA axis activity and negative affect in older adults. This study evaluated the mediating effect of the diurnal cortisol pattern on the relationship between affect and memory in older people with mild cognitive impairment (MCI). Methods This longitudinal study recruited 189 Chinese older adults with MCI from elderly centers in Hong Kong. The participants completed assessments of affect, salivary cortisol, and digit spans at baseline; neurocognitive assessments on verbal fluency, memory retrieval, and digit spans at 6-month follow-up; and instrumental activities of daily living (IADL) at 1-year follow-up. Structural equation modeling examined the direct and indirect effects of negative affect on memory and IADL via diurnal cortisol pattern. Results Controlling for covariates, negative affect significantly predicted flattened diurnal cortisol slopes (beta = 0.17, p < 0.05) but not memory or IADL (p = 0.23 - 0.91) directly. Diurnal cortisol slopes negatively predicted memory retrieval (beta = -0.20, p < 0.05), which in turn positively predicted IADL (beta = 0.22, p < 0.01). The indirect effect from negative affect to IADL via cortisol slope and memory retrieval was significant and negative (alpha beta gamma = -0.05, 95% bootstrapped CI = -0.248 to -0.001). Discussion The present study established certain temporal linkages among affect and cortisol slopes at baseline, memory retrieval at 6 months, and functional decline 1 year later in older adults with MCI. Flattened diurnal cortisol slopes might mediate the detrimental effects of negative affect on memory retrieval and functioning across 1 year.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/aging_neuroscience-
dc.relation.ispartofFrontiers in Aging Neuroscience-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectdiurnal cortisol rhythm-
dc.subjectearly dementia-
dc.subjectepisodic memory-
dc.subjectmild cognitive impairment-
dc.subjectsubjective mood-
dc.titleDiurnal Cortisol Slope Mediates the Association Between Affect and Memory Retrieval in Older Adults With Mild Cognitive Impairment: A Path-Analytical Study-
dc.typeArticle-
dc.identifier.emailHo, RTH: tinho@hku.hk-
dc.identifier.emailFong, TCT: ttaatt@hku.hk-
dc.identifier.emailYau, JCY: joshyau0@hku.hk-
dc.identifier.emailChan, WC: waicchan@hku.hk-
dc.identifier.emailKwan, JSK: jskkwan@hku.hk-
dc.identifier.emailChiu, PKC: chiukc@hku.hk-
dc.identifier.authorityHo, RTH=rp00497-
dc.identifier.authorityChan, WC=rp01687-
dc.identifier.authorityKwan, JSK=rp01868-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fnagi.2020.00035-
dc.identifier.pmid32153385-
dc.identifier.pmcidPMC7047326-
dc.identifier.scopuseid_2-s2.0-85082596431-
dc.identifier.hkuros310002-
dc.identifier.volume12-
dc.identifier.spagearticle no. 35-
dc.identifier.epagearticle no. 35-
dc.identifier.isiWOS:000523642600001-
dc.publisher.placeSwitzerland-

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