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Article: A versatile microfluidic paper chip platform based on MIPs for rapid ratiometric sensing of dual fluorescence signals

TitleA versatile microfluidic paper chip platform based on MIPs for rapid ratiometric sensing of dual fluorescence signals
Authors
KeywordsMolecular imprinting technology
Microfluidic paper chip
Polyester fiber film
Ratiometric fluorescence detection
Sensor
Issue Date2020
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/microc
Citation
Microchemical Journal, 2020, v. 157, p. article no. 105050 How to Cite?
AbstractThe aim of the present work was designed to develop a versatile rapid ratiometric fluorescent sensing platform through sequential incorporating CdTe quantum dots (CdTe QDs) and rhodamine B (RhB) and preparation of molecularly imprinted polymers on microfluidic paper chips. And in order to get better performance of paper chip, we studied a series of paper chip materials. Owing to low background fluorescence and strong binding of fluorescent CdTe QDs and RhB, polyester fiber film DL42 was selected as substrate for in-situ synthesis of molecularly imprinted polymers in the presence of the pesticide. Moreover, CdTe QDs were used as the sensing fluorescence for detecting the concentration change of the template whereas RhB was used as the control fluorescence. Dual fluorescence signals made the resulting color change more accurate under UV light. Microfluidic paper chips were characterized by infrared spectroscopy, scanning electron microscope, and fluorescence confocal microscope. Finally, microfluidic paper chips could effectively detect 2,4-dichlorophenoxyacetic acid in the range of 0.51–80 μmol/L and at the detection limit of 0.17 μmol/L in the cucumber samples, while the response time of the microfluidic paper chips was found to be 10 min. It was remarkable that the fluorescent platform could be convenient, low cost, operated easily without professionals, and quickly and specifically detect and identify templates. These advantages make the sensor suitable for the on-site family treatment or commercial products. The cucumber samples were obtained with high recovery rates ranging from 96.6% to 104.2% and the RSD was 5.5–6.1%. The successful application for the cucumber samples also proved its practicability, which was of great significance for the further development of rapid detection technology platforms and the point-of-care testing (POCT).
Persistent Identifierhttp://hdl.handle.net/10722/283770
ISSN
2019 Impact Factor: 3.594
2015 SCImago Journal Rankings: 0.930

 

DC FieldValueLanguage
dc.contributor.authorHao, G-
dc.contributor.authorZhang, Z-
dc.contributor.authorMa, X-
dc.contributor.authorZhang, R-
dc.contributor.authorQin, X-
dc.contributor.authorSun, H-
dc.contributor.authorYang, X-
dc.contributor.authorRong, J-
dc.date.accessioned2020-07-03T08:23:51Z-
dc.date.available2020-07-03T08:23:51Z-
dc.date.issued2020-
dc.identifier.citationMicrochemical Journal, 2020, v. 157, p. article no. 105050-
dc.identifier.issn0026-265X-
dc.identifier.urihttp://hdl.handle.net/10722/283770-
dc.description.abstractThe aim of the present work was designed to develop a versatile rapid ratiometric fluorescent sensing platform through sequential incorporating CdTe quantum dots (CdTe QDs) and rhodamine B (RhB) and preparation of molecularly imprinted polymers on microfluidic paper chips. And in order to get better performance of paper chip, we studied a series of paper chip materials. Owing to low background fluorescence and strong binding of fluorescent CdTe QDs and RhB, polyester fiber film DL42 was selected as substrate for in-situ synthesis of molecularly imprinted polymers in the presence of the pesticide. Moreover, CdTe QDs were used as the sensing fluorescence for detecting the concentration change of the template whereas RhB was used as the control fluorescence. Dual fluorescence signals made the resulting color change more accurate under UV light. Microfluidic paper chips were characterized by infrared spectroscopy, scanning electron microscope, and fluorescence confocal microscope. Finally, microfluidic paper chips could effectively detect 2,4-dichlorophenoxyacetic acid in the range of 0.51–80 μmol/L and at the detection limit of 0.17 μmol/L in the cucumber samples, while the response time of the microfluidic paper chips was found to be 10 min. It was remarkable that the fluorescent platform could be convenient, low cost, operated easily without professionals, and quickly and specifically detect and identify templates. These advantages make the sensor suitable for the on-site family treatment or commercial products. The cucumber samples were obtained with high recovery rates ranging from 96.6% to 104.2% and the RSD was 5.5–6.1%. The successful application for the cucumber samples also proved its practicability, which was of great significance for the further development of rapid detection technology platforms and the point-of-care testing (POCT).-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/microc-
dc.relation.ispartofMicrochemical Journal-
dc.subjectMolecular imprinting technology-
dc.subjectMicrofluidic paper chip-
dc.subjectPolyester fiber film-
dc.subjectRatiometric fluorescence detection-
dc.subjectSensor-
dc.titleA versatile microfluidic paper chip platform based on MIPs for rapid ratiometric sensing of dual fluorescence signals-
dc.typeArticle-
dc.identifier.emailRong, J: jrong@hku.hk-
dc.identifier.authorityRong, J=rp00515-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.microc.2020.105050-
dc.identifier.scopuseid_2-s2.0-85085281316-
dc.identifier.hkuros310725-
dc.identifier.volume157-
dc.identifier.spagearticle no. 105050-
dc.identifier.epagearticle no. 105050-
dc.publisher.placeUnited States-

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