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Article: The role of dopamine dysregulation and evidence for the transdiagnostic nature of elevated dopamine synthesis in psychosis: a positron emission tomography (PET) study comparing schizophrenia, delusional disorder, and other psychotic disorders

TitleThe role of dopamine dysregulation and evidence for the transdiagnostic nature of elevated dopamine synthesis in psychosis: a positron emission tomography (PET) study comparing schizophrenia, delusional disorder, and other psychotic disorders
Authors
KeywordsRaclopride
Corpus Striatum
Dopamine
Issue Date2020
PublisherNature Publishing Group. The Journal's web site is located at http://www.neuropsychopharmacology.org
Citation
Neuropsychopharmacology, 2020, Epub 2020-07-01 How to Cite?
AbstractThere have been few studies performed to examine the pathophysiological differences between different types of psychosis, such as between delusional disorder (DD) and schizophrenia (SZ). Notably, despite the different clinical characteristics of DD and schizophrenia (SZ), antipsychotics are deemed equally effective pharmaceutical treatments for both conditions. In this context, dopamine dysregulation may be transdiagnostic of the pathophysiology of psychotic disorders such as DD and SZ. In this study, an examination is made of the dopamine synthesis capacity (DSC) of patients with SZ, DD, other psychotic disorders, and the DSC of healthy subjects. Fifty-four subjects were recruited to the study, comprising 35 subjects with first-episode psychosis (11 DD, 12 SZ, 12 other psychotic disorders) and 19 healthy controls. All received an 18F-DOPA positron emission tomography (PET)/magnetic resonance (MR) scan to measure DSC (Kocc;30–60 value) within 1 month of starting antipsychotic treatment. Clinical assessments were also made, which included Positive and Negative Syndrome Scale (PANSS) measurements. The mean Kocc;30–60 was significantly greater in the caudate region of subjects in the DD group (ES = 0.83, corrected p = 0.048), the SZ group (ES = 1.40, corrected p = 0.003) and the other psychotic disorder group (ES = 1.34, corrected p = 0.0045), compared to that of the control group. These data indicate that DD, SZ, and other psychotic disorders have similar dysregulated mechanisms of dopamine synthesis, which supports the utility of abnormal dopamine synthesis in transdiagnoses of these psychotic conditions.
Persistent Identifierhttp://hdl.handle.net/10722/284110
ISSN
2019 Impact Factor: 6.751
2015 SCImago Journal Rankings: 3.517

 

DC FieldValueLanguage
dc.contributor.authorCheng, PWC-
dc.contributor.authorChang, WC-
dc.contributor.authorLo, GG-
dc.contributor.authorChan, KWS-
dc.contributor.authorLee, HME-
dc.contributor.authorHui, LMC-
dc.contributor.authorSuen, YN-
dc.contributor.authorLeung, YLE-
dc.contributor.authorAu Yeung, KMP-
dc.contributor.authorChen, S-
dc.contributor.authorMak, KFH-
dc.contributor.authorSham, PC-
dc.contributor.authorSantangelo, B-
dc.contributor.authorVeronese, M-
dc.contributor.authorHo, CL-
dc.contributor.authorChen, YHE-
dc.contributor.authorHowes, OD-
dc.date.accessioned2020-07-20T05:56:10Z-
dc.date.available2020-07-20T05:56:10Z-
dc.date.issued2020-
dc.identifier.citationNeuropsychopharmacology, 2020, Epub 2020-07-01-
dc.identifier.issn0893-133X-
dc.identifier.urihttp://hdl.handle.net/10722/284110-
dc.description.abstractThere have been few studies performed to examine the pathophysiological differences between different types of psychosis, such as between delusional disorder (DD) and schizophrenia (SZ). Notably, despite the different clinical characteristics of DD and schizophrenia (SZ), antipsychotics are deemed equally effective pharmaceutical treatments for both conditions. In this context, dopamine dysregulation may be transdiagnostic of the pathophysiology of psychotic disorders such as DD and SZ. In this study, an examination is made of the dopamine synthesis capacity (DSC) of patients with SZ, DD, other psychotic disorders, and the DSC of healthy subjects. Fifty-four subjects were recruited to the study, comprising 35 subjects with first-episode psychosis (11 DD, 12 SZ, 12 other psychotic disorders) and 19 healthy controls. All received an 18F-DOPA positron emission tomography (PET)/magnetic resonance (MR) scan to measure DSC (Kocc;30–60 value) within 1 month of starting antipsychotic treatment. Clinical assessments were also made, which included Positive and Negative Syndrome Scale (PANSS) measurements. The mean Kocc;30–60 was significantly greater in the caudate region of subjects in the DD group (ES = 0.83, corrected p = 0.048), the SZ group (ES = 1.40, corrected p = 0.003) and the other psychotic disorder group (ES = 1.34, corrected p = 0.0045), compared to that of the control group. These data indicate that DD, SZ, and other psychotic disorders have similar dysregulated mechanisms of dopamine synthesis, which supports the utility of abnormal dopamine synthesis in transdiagnoses of these psychotic conditions.-
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.neuropsychopharmacology.org-
dc.relation.ispartofNeuropsychopharmacology-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.subjectRaclopride-
dc.subjectCorpus Striatum-
dc.subjectDopamine-
dc.titleThe role of dopamine dysregulation and evidence for the transdiagnostic nature of elevated dopamine synthesis in psychosis: a positron emission tomography (PET) study comparing schizophrenia, delusional disorder, and other psychotic disorders-
dc.typeArticle-
dc.identifier.emailCheng, PWC: chengpsy@hku.hk-
dc.identifier.emailChang, WC: changwc@hku.hk-
dc.identifier.emailChan, KWS: kwsherry@hku.hk-
dc.identifier.emailLee, HME: edwinlhm@hku.hk-
dc.identifier.emailHui, LMC: christyh@hku.hk-
dc.identifier.emailSuen, YN: suenyn@hku.hk-
dc.identifier.emailSham, PC: pcsham@hku.hk-
dc.identifier.emailChen, YHE: eyhchen@hku.hk-
dc.identifier.authorityCheng, PWC=rp02333-
dc.identifier.authorityChang, WC=rp01465-
dc.identifier.authorityChan, KWS=rp00539-
dc.identifier.authorityLee, HME=rp01575-
dc.identifier.authorityHui, LMC=rp01993-
dc.identifier.authoritySuen, YN=rp02481-
dc.identifier.authoritySham, PC=rp00459-
dc.identifier.authorityChen, YHE=rp00392-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/s41386-020-0740-x-
dc.identifier.scopuseid_2-s2.0-85087285206-
dc.identifier.hkuros310814-
dc.identifier.volumeEpub 2020-07-01-
dc.publisher.placeUnited Kingdom-

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