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Article: Improved total synthesis of the antibiotic A54145B

TitleImproved total synthesis of the antibiotic A54145B
Authors
Chow, HYChen, DLi, X
KeywordsDAPTOMYCIN
CYCLIZATION
ANALOGS
Issue Date2020
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/obc
Citation
Organic & Biomolecular Chemistry, 2020, v. 18 n. 23, p. 4401-4405 How to Cite?
DOI: http://dx.doi.org/10.1039/D0OB00558D
AbstractA54145B is a calcium-dependent cyclic lipodepsipeptide antibiotic that is active against Gram-positive pathogens. Herein, we report an improved synthetic route toward A54145B in terms of the yield and time required. The key changes include using a pre-assembled minimalist tetradepsipeptide building block to solve the difficult on-resin esterification from our previous synthetic route, and a new macrocyclization site to avoid the peptide self-cleavage problem.
Persistent Identifierhttp://hdl.handle.net/10722/284531
ISSN
1477-0520
2021 Impact Factor: 3.890
2020 SCImago Journal Rankings: 0.923
ISI Accession Number ID
WOS:000542959000009
Grants
Total Synthesis and Medicinal Chemistry of Cyclic Peptide-based Antibacterial Compounds: An Integrative Programme for Novel Antibiotic Development

 

DC FieldValueLanguage
dc.contributor.authorChow, HY-
dc.contributor.authorChen, D-
dc.contributor.authorLi, X-
dc.date.accessioned2020-08-07T08:58:58Z-
dc.date.available2020-08-07T08:58:58Z-
dc.date.issued2020-
dc.identifier.citationOrganic & Biomolecular Chemistry, 2020, v. 18 n. 23, p. 4401-4405-
dc.identifier.issn1477-0520-
dc.identifier.urihttp://hdl.handle.net/10722/284531-
dc.description.abstractA54145B is a calcium-dependent cyclic lipodepsipeptide antibiotic that is active against Gram-positive pathogens. Herein, we report an improved synthetic route toward A54145B in terms of the yield and time required. The key changes include using a pre-assembled minimalist tetradepsipeptide building block to solve the difficult on-resin esterification from our previous synthetic route, and a new macrocyclization site to avoid the peptide self-cleavage problem.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/obc-
dc.relation.ispartofOrganic & Biomolecular Chemistry-
dc.subjectDAPTOMYCIN-
dc.subjectCYCLIZATION-
dc.subjectANALOGS-
dc.titleImproved total synthesis of the antibiotic A54145B-
dc.typeArticle-
dc.identifier.emailChow, HY: hchowhy@connect.hku.hk-
dc.identifier.emailChen, D: delinc@hku.hk-
dc.identifier.emailLi, X: xuechenl@hku.hk-
dc.identifier.authorityLi, X=rp00742-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/D0OB00558D-
dc.identifier.scopuseid_2-s2.0-85092621037-
dc.identifier.hkuros311894-
dc.identifier.volume18-
dc.identifier.issue23-
dc.identifier.spage4401-
dc.identifier.epage4405-
dc.identifier.isiWOS:000542959000009-
dc.publisher.placeUnited Kingdom-
dc.relation.projectTotal Synthesis and Medicinal Chemistry of Cyclic Peptide-based Antibacterial Compounds: An Integrative Programme for Novel Antibiotic Development-
dc.identifier.issnl1477-0520-

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