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Conference Paper: Role of osteogenic circulating endothelial progenitor cells in dissemination of large arterial calcification in rheumatoid arthritis

TitleRole of osteogenic circulating endothelial progenitor cells in dissemination of large arterial calcification in rheumatoid arthritis
Authors
KeywordsPeripheral Artery Disease
Issue Date2019
PublisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
Citation
European Society of Cardiology (ESC) Congress 2019 & World Congress of Cardiology, Paris, France, 31 August – 4 September 2019. In European Heart Journal, 2019, v. 40 n. Suppl. 1 How to Cite?
AbstractBackground: Rheumatoid arthritis is associated with both abnormal bone metabolism and atherogenesis but mechanistic links were missing. Aim: This study aimed to investigate the role of osteocalcin (OCN)-expressing circulating endothelial progenitor cells (EPC)s in the severity and dissemination of systemic arterial calcifications in rheumatoid arthritis. Methods: We performed flow cytometry studies in 145 consecutive patients with rheumatoid arthritis to determine osteogenic circulating levels of OCN-positive (OCN+) CD34+KDR+ and OCN+CD34+, versus conventional early EPC CD34+CD133+KDR+. Total calcium load of the thoracic aorta (ascending plus descending) and the carotid arteries were assessed by non-contrast computed tomography (CT) and contrast CT angiography. Results: Osteogenic EPCs OCN+CD34+KDR+ (P=0.002) and OCN+CD34+ were strikingly associated with the clustered presence of aortic and carotid calcification (P=0.002 and 0.001 respectively, Figure). Multivariable analyses revealed that circulating OCN+CD34+KDR+ (B=14.4 [95% CI 4.0 to 24.8], P=0.007) and OCN+CD34+ (B=9.6 [95% CI 4.9 to 14.3], P<0.001) remained independently associated with increased aortic calcium load. OCN+CD34+ EPC (B=0.8 [95% CI 0.1 to 1.5], P=0.023), but not OCN+CD34+KDR+ EPC (B=1.2 [95% CI −0.2 to 2.6], P=0.09) was further independently associated with carotid calcium load. In comparison, conventional early EPC CD34+CD133+KDR+ had no significant association with aortic or carotid calcium load (P=0.46 and 0.88, respectively). Conclusions: Circulating level of osteogenic EPC is associated with promulgated aortic and carotid calcification in patients with rheumatoid arthritis, suggesting a potential mechanistic role of the bone-vascular axis in pro-atherogenicity of rheumatic diseases.
DescriptionNew data in carotid disease: From understanding the pathology to management: Carotid Disease - abstract no. 3045
Persistent Identifierhttp://hdl.handle.net/10722/284917
ISSN
2019 Impact Factor: 22.673
2015 SCImago Journal Rankings: 6.997

 

DC FieldValueLanguage
dc.contributor.authorChan, YH-
dc.contributor.authorNgai, MC-
dc.contributor.authorChen, Y-
dc.contributor.authorWu, M-
dc.contributor.authorYu, Y-
dc.contributor.authorZhen, Z-
dc.contributor.authorLai, K-
dc.contributor.authorCheung, TT-
dc.contributor.authorHo, LM-
dc.contributor.authorChung, HY-
dc.contributor.authorLau, CP-
dc.contributor.authorTse, HF-
dc.contributor.authorYiu, KH-
dc.date.accessioned2020-08-07T09:04:20Z-
dc.date.available2020-08-07T09:04:20Z-
dc.date.issued2019-
dc.identifier.citationEuropean Society of Cardiology (ESC) Congress 2019 & World Congress of Cardiology, Paris, France, 31 August – 4 September 2019. In European Heart Journal, 2019, v. 40 n. Suppl. 1-
dc.identifier.issn0195-668X-
dc.identifier.urihttp://hdl.handle.net/10722/284917-
dc.descriptionNew data in carotid disease: From understanding the pathology to management: Carotid Disease - abstract no. 3045-
dc.description.abstractBackground: Rheumatoid arthritis is associated with both abnormal bone metabolism and atherogenesis but mechanistic links were missing. Aim: This study aimed to investigate the role of osteocalcin (OCN)-expressing circulating endothelial progenitor cells (EPC)s in the severity and dissemination of systemic arterial calcifications in rheumatoid arthritis. Methods: We performed flow cytometry studies in 145 consecutive patients with rheumatoid arthritis to determine osteogenic circulating levels of OCN-positive (OCN+) CD34+KDR+ and OCN+CD34+, versus conventional early EPC CD34+CD133+KDR+. Total calcium load of the thoracic aorta (ascending plus descending) and the carotid arteries were assessed by non-contrast computed tomography (CT) and contrast CT angiography. Results: Osteogenic EPCs OCN+CD34+KDR+ (P=0.002) and OCN+CD34+ were strikingly associated with the clustered presence of aortic and carotid calcification (P=0.002 and 0.001 respectively, Figure). Multivariable analyses revealed that circulating OCN+CD34+KDR+ (B=14.4 [95% CI 4.0 to 24.8], P=0.007) and OCN+CD34+ (B=9.6 [95% CI 4.9 to 14.3], P<0.001) remained independently associated with increased aortic calcium load. OCN+CD34+ EPC (B=0.8 [95% CI 0.1 to 1.5], P=0.023), but not OCN+CD34+KDR+ EPC (B=1.2 [95% CI −0.2 to 2.6], P=0.09) was further independently associated with carotid calcium load. In comparison, conventional early EPC CD34+CD133+KDR+ had no significant association with aortic or carotid calcium load (P=0.46 and 0.88, respectively). Conclusions: Circulating level of osteogenic EPC is associated with promulgated aortic and carotid calcification in patients with rheumatoid arthritis, suggesting a potential mechanistic role of the bone-vascular axis in pro-atherogenicity of rheumatic diseases.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/-
dc.relation.ispartofEuropean Heart Journal-
dc.relation.ispartofEuropean Society of Cardiology (ESC) Congress 2019 & World Congress of Cardiology-
dc.subjectPeripheral Artery Disease-
dc.titleRole of osteogenic circulating endothelial progenitor cells in dissemination of large arterial calcification in rheumatoid arthritis-
dc.typeConference_Paper-
dc.identifier.emailCheung, TT: tcheungt@hku.hk-
dc.identifier.emailHo, LM: lmho@hku.hk-
dc.identifier.emailChung, HY: jameschy@hku.hk-
dc.identifier.emailLau, CP: cplau@hkucc.hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.authorityCheung, TT=rp01682-
dc.identifier.authorityHo, LM=rp00360-
dc.identifier.authorityChung, HY=rp02330-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.doi10.1093/eurheartj/ehz745.0012-
dc.identifier.hkuros311770-
dc.identifier.volume40-
dc.identifier.issueSuppl. 1-
dc.publisher.placeUnited Kingdom-

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