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Conference Paper: Sex-specific pattern of left ventricular hypertrophy and diastolic function in patients with type 2 diabetes mellitus

TitleSex-specific pattern of left ventricular hypertrophy and diastolic function in patients with type 2 diabetes mellitus
Authors
KeywordsCardiovascular Disease in Women
Issue Date2019
PublisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
Citation
European Society of Cardiology (ESC) Congress 2019 & World Congress of Cardiology, Paris, France, 31 August – 4 September 2019. In European Heart Journal, 2019, v. 40 n. Suppl. 1, abstract no. P3461 How to Cite?
AbstractBackground: Few prospective studies have evaluated sex-specific pattern, natural progression of left ventricular (LV) remodeling and diastolic dysfunction in patients with type 2 diabetes (T2DM). Purpose: The aim of this study was to study the sex-specific prevalence, longitudinal changes of LV remodeling and diastolic dysfunction in patients with T2DM. Further the prognostic value of diastolic function in women and men was also evaluated. Methods: A total of 386 patients with T2DM (mean age 61±11 years; women, 48.2%) was recruited. Detailed echocardiography was performed and LV geometry, systolic and diastolic function were measured at baseline and follow-up. A major adverse cardiovascular event (MACE) was defined as cardiovascular death, heart failure hospitalization or myocardial infarction. Multivariable cox-regression adjusted for age, hypertension, LVEF and HbA1c was used to assess the association between sex-specific diastolic function and the development of a MACE. Results: Despite a similar age, prevalence of hypertension and body mass index, women had a higher prevalence of LV hypertrophy and diastolic dysfunction at baseline and follow-up compared with men. A total of 26 patients developed a MACE (4 cardiovascular death, 14 hospitalization for heart failure, 8 myocardial infarction) during follow-up. Women with diastolic dysfunction had a higher incidence of MACE than those with normal diastolic function but this association was neutral in men. Multivariable Cox-regression analysis indicated that diastolic dysfunction was associated with MACE in women (hazard ratio 6.35, 95% confidence interval 1.18–34.19, P<0.05) but not men (hazard ratio 1.85, 95% confidence interval 0.58–5.92, P=0.30). Conclusions: LV hypertrophy and diastolic dysfunction, both at baseline and follow-up, were more common in women than men. Pre-clinical diastolic dysfunction was independently associated with MACE only in women with T2DM but was neutral in men.
DescriptionPoster Session 4: Cardiovascular Disease in Women - no. P3461
Persistent Identifierhttp://hdl.handle.net/10722/285108
ISSN
2019 Impact Factor: 22.673
2015 SCImago Journal Rankings: 6.997

 

DC FieldValueLanguage
dc.contributor.authorWu, M-
dc.contributor.authorChen, Y-
dc.contributor.authorYu, Y-
dc.contributor.authorTse, HF-
dc.contributor.authorYiu, KH-
dc.date.accessioned2020-08-07T09:06:52Z-
dc.date.available2020-08-07T09:06:52Z-
dc.date.issued2019-
dc.identifier.citationEuropean Society of Cardiology (ESC) Congress 2019 & World Congress of Cardiology, Paris, France, 31 August – 4 September 2019. In European Heart Journal, 2019, v. 40 n. Suppl. 1, abstract no. P3461-
dc.identifier.issn0195-668X-
dc.identifier.urihttp://hdl.handle.net/10722/285108-
dc.descriptionPoster Session 4: Cardiovascular Disease in Women - no. P3461-
dc.description.abstractBackground: Few prospective studies have evaluated sex-specific pattern, natural progression of left ventricular (LV) remodeling and diastolic dysfunction in patients with type 2 diabetes (T2DM). Purpose: The aim of this study was to study the sex-specific prevalence, longitudinal changes of LV remodeling and diastolic dysfunction in patients with T2DM. Further the prognostic value of diastolic function in women and men was also evaluated. Methods: A total of 386 patients with T2DM (mean age 61±11 years; women, 48.2%) was recruited. Detailed echocardiography was performed and LV geometry, systolic and diastolic function were measured at baseline and follow-up. A major adverse cardiovascular event (MACE) was defined as cardiovascular death, heart failure hospitalization or myocardial infarction. Multivariable cox-regression adjusted for age, hypertension, LVEF and HbA1c was used to assess the association between sex-specific diastolic function and the development of a MACE. Results: Despite a similar age, prevalence of hypertension and body mass index, women had a higher prevalence of LV hypertrophy and diastolic dysfunction at baseline and follow-up compared with men. A total of 26 patients developed a MACE (4 cardiovascular death, 14 hospitalization for heart failure, 8 myocardial infarction) during follow-up. Women with diastolic dysfunction had a higher incidence of MACE than those with normal diastolic function but this association was neutral in men. Multivariable Cox-regression analysis indicated that diastolic dysfunction was associated with MACE in women (hazard ratio 6.35, 95% confidence interval 1.18–34.19, P<0.05) but not men (hazard ratio 1.85, 95% confidence interval 0.58–5.92, P=0.30). Conclusions: LV hypertrophy and diastolic dysfunction, both at baseline and follow-up, were more common in women than men. Pre-clinical diastolic dysfunction was independently associated with MACE only in women with T2DM but was neutral in men.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/-
dc.relation.ispartofEuropean Heart Journal-
dc.relation.ispartofEuropean Society of Cardiology (ESC) Congress 2019 & World Congress of Cardiology-
dc.subjectCardiovascular Disease in Women-
dc.titleSex-specific pattern of left ventricular hypertrophy and diastolic function in patients with type 2 diabetes mellitus-
dc.typeConference_Paper-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.doi10.1093/eurheartj/ehz745.0334-
dc.identifier.hkuros311771-
dc.identifier.volume40-
dc.identifier.issueSuppl. 1-
dc.publisher.placeUnited Kingdom-

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