File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus

TitleProstratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus
Authors
Issue Date2005
Citation
Antiviral Therapy, 2005, v. 10, n. 6, p. 745-751 How to Cite?
AbstractKaposi's sarcoma-associated herpesvirus (KSHV) establishes latent infections in lymphocytes and endothelial cells, and latent infection is closely linked to tumorigenesis. As few viral markers are expressed during latency, compounds that can safely and efficiently increase lytic gene expression in vivo have been sought. We have found that the non-tumour-promoting phorbol ester prostratin and the proteasome inhibitor bortezomib induce immediate-early, early and late KSHV gene expression from two lymphoma cell lines in vitro. Their ability to induce lytic gene expression supports a role for phorbol-ester and proteasome-regulated signalling pathways in KSHV reactivation and prompts further investigation of prostratin and bortezomib as therapeutic agents for KSHV-associated malignancies. © 2005 International Medical Press.
Persistent Identifierhttp://hdl.handle.net/10722/285890
ISSN
2019 Impact Factor: 2.043
2015 SCImago Journal Rankings: 1.361
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBrown, Helen J.-
dc.contributor.authorMcBride, William H.-
dc.contributor.authorZack, Jerome A.-
dc.contributor.authorSun, Ren-
dc.date.accessioned2020-08-18T04:56:55Z-
dc.date.available2020-08-18T04:56:55Z-
dc.date.issued2005-
dc.identifier.citationAntiviral Therapy, 2005, v. 10, n. 6, p. 745-751-
dc.identifier.issn1359-6535-
dc.identifier.urihttp://hdl.handle.net/10722/285890-
dc.description.abstractKaposi's sarcoma-associated herpesvirus (KSHV) establishes latent infections in lymphocytes and endothelial cells, and latent infection is closely linked to tumorigenesis. As few viral markers are expressed during latency, compounds that can safely and efficiently increase lytic gene expression in vivo have been sought. We have found that the non-tumour-promoting phorbol ester prostratin and the proteasome inhibitor bortezomib induce immediate-early, early and late KSHV gene expression from two lymphoma cell lines in vitro. Their ability to induce lytic gene expression supports a role for phorbol-ester and proteasome-regulated signalling pathways in KSHV reactivation and prompts further investigation of prostratin and bortezomib as therapeutic agents for KSHV-associated malignancies. © 2005 International Medical Press.-
dc.languageeng-
dc.relation.ispartofAntiviral Therapy-
dc.titleProstratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid16218174-
dc.identifier.scopuseid_2-s2.0-25444459935-
dc.identifier.volume10-
dc.identifier.issue6-
dc.identifier.spage745-
dc.identifier.epage751-
dc.identifier.isiWOS:000232446400008-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats