File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The relationship between loneliness and working-memory-related frontoparietal network connectivity in people with major depressive disorder

TitleThe relationship between loneliness and working-memory-related frontoparietal network connectivity in people with major depressive disorder
Authors
KeywordsMajor depressive disorder
Loneliness
Working memory
Functional connectivity
Cognitive control
Dorsomedial prefrontal cortex
Issue Date2020
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbr
Citation
Behavioural Brain Research, 2020, v. 393, article no. 112776 How to Cite?
AbstractLoneliness affects up to 40 % of middle-aged and older adults, and is closely associated with major depressive disorder (MDD). However, the relationship between loneliness and neural network functioning during executive cognitive processes, such as working memory, in MDD is still unclear. To address this gap, our study recruited 21 medicated MDD patients (mean age = 52.0 ± 5 years) and 24 matched healthy controls (HC) (mean age = 48.7 ± 6 years) who completed an n-back fMRI task. For behavioural performance, we observed no significant moderating effect of MDD or loneliness on the task condition effect. However, loneliness was positively associated, and MDD was negatively associated, with the functional connectivity between the inferior parietal cortex and the rostral dorsomedial prefrontal cortex (DMPFC) during task performance. Furthermore, an interactive effect of loneliness and MDD was observed on the functional connectivity between the supplementary motor area and the caudal DMPFC during the n-back task, with loneliness showing a positive relationship in the HC group but a negative relationship in the MDD group with the connectivity. Our results indicated that loneliness may be associated with altered neural regulatory functioning on self-referential processing and action control, which may further depend on the individual’s depressive state. These findings can form the theoretical basis for devising intervention programme aimed at improving the mental wellness of the healthy and depressed lonely individuals.
Persistent Identifierhttp://hdl.handle.net/10722/286120
ISSN
2019 Impact Factor: 2.977
2015 SCImago Journal Rankings: 1.533
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGao, M-
dc.contributor.authorShao, R-
dc.contributor.authorHuang, C-
dc.contributor.authorLiu, H-
dc.contributor.authorChen, Y-
dc.contributor.authorLee, S-
dc.contributor.authorLin, C-
dc.contributor.authorLee, TMC-
dc.date.accessioned2020-08-31T06:59:24Z-
dc.date.available2020-08-31T06:59:24Z-
dc.date.issued2020-
dc.identifier.citationBehavioural Brain Research, 2020, v. 393, article no. 112776-
dc.identifier.issn0166-4328-
dc.identifier.urihttp://hdl.handle.net/10722/286120-
dc.description.abstractLoneliness affects up to 40 % of middle-aged and older adults, and is closely associated with major depressive disorder (MDD). However, the relationship between loneliness and neural network functioning during executive cognitive processes, such as working memory, in MDD is still unclear. To address this gap, our study recruited 21 medicated MDD patients (mean age = 52.0 ± 5 years) and 24 matched healthy controls (HC) (mean age = 48.7 ± 6 years) who completed an n-back fMRI task. For behavioural performance, we observed no significant moderating effect of MDD or loneliness on the task condition effect. However, loneliness was positively associated, and MDD was negatively associated, with the functional connectivity between the inferior parietal cortex and the rostral dorsomedial prefrontal cortex (DMPFC) during task performance. Furthermore, an interactive effect of loneliness and MDD was observed on the functional connectivity between the supplementary motor area and the caudal DMPFC during the n-back task, with loneliness showing a positive relationship in the HC group but a negative relationship in the MDD group with the connectivity. Our results indicated that loneliness may be associated with altered neural regulatory functioning on self-referential processing and action control, which may further depend on the individual’s depressive state. These findings can form the theoretical basis for devising intervention programme aimed at improving the mental wellness of the healthy and depressed lonely individuals.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbr-
dc.relation.ispartofBehavioural Brain Research-
dc.subjectMajor depressive disorder-
dc.subjectLoneliness-
dc.subjectWorking memory-
dc.subjectFunctional connectivity-
dc.subjectCognitive control-
dc.subjectDorsomedial prefrontal cortex-
dc.titleThe relationship between loneliness and working-memory-related frontoparietal network connectivity in people with major depressive disorder-
dc.typeArticle-
dc.identifier.emailShao, R: rshao@hku.hk-
dc.identifier.emailLee, TMC: tmclee@hku.hk-
dc.identifier.authorityShao, R=rp02519-
dc.identifier.authorityLee, TMC=rp00564-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbr.2020.112776-
dc.identifier.pmid32615139-
dc.identifier.scopuseid_2-s2.0-85088374512-
dc.identifier.hkuros313766-
dc.identifier.volume393-
dc.identifier.spagearticle no. 112776-
dc.identifier.epagearticle no. 112776-
dc.identifier.isiWOS:000557870200026-
dc.publisher.placeNetherlands-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats