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Article: Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

TitleAlcohol drinking and head and neck cancer risk: the joint effect of intensity and duration
Authors
Issue Date2020
PublisherSpringer Nature, published in association with Cancer Research UK. The Journal's web site is located at http://www.nature.com/bjc
Citation
British Journal of Cancer, 2020 How to Cite?
AbstractBackground: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. Results: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). Conclusions: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.
Persistent Identifierhttp://hdl.handle.net/10722/286147
ISSN
2019 Impact Factor: 5.791
2015 SCImago Journal Rankings: 2.939
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDi Credico, G-
dc.contributor.authorPolesel, J-
dc.contributor.authorDal Maso, L-
dc.contributor.authorPauli, F-
dc.contributor.authorTorelli, N-
dc.contributor.authorLuce, D-
dc.contributor.authorRadoï, L-
dc.contributor.authorMatsuo, K-
dc.contributor.authorSerraino, D-
dc.contributor.authorBrennan, P-
dc.contributor.authorHolcatova, I-
dc.contributor.authorAhrens, W-
dc.contributor.authorLagiou, P-
dc.contributor.authorCanova, C-
dc.contributor.authorRichiardi, L-
dc.contributor.authorHealy, CM-
dc.contributor.authorKjaerheim, K-
dc.contributor.authorConway, DI-
dc.contributor.authorMacfarlane, GJ-
dc.contributor.authorThomson, P-
dc.contributor.authorAgudo, A-
dc.contributor.authorZnaor, A-
dc.contributor.authorFranceschi, S-
dc.contributor.authorHerrero, R-
dc.contributor.authorToporcov, TN-
dc.contributor.authorMoyses, RA-
dc.contributor.authorMuscat, J-
dc.contributor.authorNegri, E-
dc.contributor.authorVilensky, M-
dc.contributor.authorFernandez, L-
dc.contributor.authorCurado, MP-
dc.contributor.authorMenezes, A-
dc.contributor.authorDaudt, AW-
dc.contributor.authorKoifman, R-
dc.contributor.authorWunsch-Filho, V-
dc.contributor.authorOlshan, AF-
dc.contributor.authorZevallos, JP-
dc.contributor.authorSturgis, EM-
dc.contributor.authorLi, G-
dc.contributor.authorLevi, F-
dc.contributor.authorZhang, ZF-
dc.contributor.authorMorgenstern, H-
dc.contributor.authorSmith, E-
dc.contributor.authorLazarus, P-
dc.contributor.authorLa Vecchia, C-
dc.contributor.authorGaravello, W-
dc.contributor.authorChen, C-
dc.contributor.authorSchwartz, SM-
dc.contributor.authorZheng, T-
dc.contributor.authorVaughan, TL-
dc.contributor.authorKelsey, K-
dc.contributor.authorMcClean, M-
dc.contributor.authorBenhamou, S-
dc.contributor.authorHayes, RB-
dc.contributor.authorPurdue, MP-
dc.contributor.authorGillison, M-
dc.contributor.authorSchantz, S-
dc.contributor.authorYu, GP-
dc.contributor.authorChuang, SC-
dc.contributor.authorBoffetta, P-
dc.contributor.authorHashibe, M-
dc.contributor.authorYuan-Chin, AL-
dc.contributor.authorEdefonti, V-
dc.date.accessioned2020-08-31T06:59:48Z-
dc.date.available2020-08-31T06:59:48Z-
dc.date.issued2020-
dc.identifier.citationBritish Journal of Cancer, 2020-
dc.identifier.issn0007-0920-
dc.identifier.urihttp://hdl.handle.net/10722/286147-
dc.description.abstractBackground: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. Results: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). Conclusions: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.-
dc.languageeng-
dc.publisherSpringer Nature, published in association with Cancer Research UK. The Journal's web site is located at http://www.nature.com/bjc-
dc.relation.ispartofBritish Journal of Cancer-
dc.titleAlcohol drinking and head and neck cancer risk: the joint effect of intensity and duration-
dc.typeArticle-
dc.identifier.emailThomson, P: thomsonp@hku.hk-
dc.identifier.authorityThomson, P=rp02327-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/s41416-020-01031-z-
dc.identifier.pmid32830199-
dc.identifier.scopuseid_2-s2.0-85089733609-
dc.identifier.hkuros313708-
dc.identifier.isiWOS:000562007700006-
dc.publisher.placeUnited Kingdom-

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