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Book: Bismuth drugs as antimicrobial agents

TitleBismuth drugs as antimicrobial agents
Authors
KeywordsBismuth drug
Helicobacter pylori
Antimicrobial agent
Resistance breaker
Issue Date2020
PublisherAcademic Press
Citation
Bismuth drugs as antimicrobial agents. In Sadler, PF & van Eldik, R (Eds.), Advances in Inorganic Chemistry, v. 75, p. 183-205. Cambridge, MA: Academic Press, 2020 How to Cite?
AbstractBismuth-based agents have been widely used in medicine, particularly as the active components for the treatment of Helicobacter pylori-associated gastrointestinal ailments. The selective toxicity of bismuth toward Helicobacter pylori stems from the intrinsic chemical and biological properties of bismuth. The molecular targets of bismuth agents and their antimicrobial mechanisms of action are reviewed. Beyond anti-Helicobacter pylori actions, novel bismuth-based agents with broad antimicrobial activities against both Gram-positive and Gram-negative bacterial pathogens are highlighted. Intriguingly, bismuth-based combination therapy could effectively treat infections caused by antibiotic resistant superbugs. This chapter strives to offer an account of state-of-the-art research progress on antibacterial mechanisms of action of bismuth and explore the frontiers of up-to-date potential medicinal applications of bismuth-based agents with reference to recent developments in the literature.
DescriptionChapter Six
Volume title: Medicinal Chemistry
Persistent Identifierhttp://hdl.handle.net/10722/286558
ISBN
ISSN
2019 Impact Factor: 2.658
2015 SCImago Journal Rankings: 1.132

 

DC FieldValueLanguage
dc.contributor.authorWang, R-
dc.contributor.authorLi, H-
dc.contributor.authorIp, KYT-
dc.contributor.authorSun, H-
dc.date.accessioned2020-08-31T07:05:30Z-
dc.date.available2020-08-31T07:05:30Z-
dc.date.issued2020-
dc.identifier.citationBismuth drugs as antimicrobial agents. In Sadler, PF & van Eldik, R (Eds.), Advances in Inorganic Chemistry, v. 75, p. 183-205. Cambridge, MA: Academic Press, 2020-
dc.identifier.isbn9780128191965-
dc.identifier.issn0898-8838-
dc.identifier.urihttp://hdl.handle.net/10722/286558-
dc.descriptionChapter Six-
dc.descriptionVolume title: Medicinal Chemistry-
dc.description.abstractBismuth-based agents have been widely used in medicine, particularly as the active components for the treatment of Helicobacter pylori-associated gastrointestinal ailments. The selective toxicity of bismuth toward Helicobacter pylori stems from the intrinsic chemical and biological properties of bismuth. The molecular targets of bismuth agents and their antimicrobial mechanisms of action are reviewed. Beyond anti-Helicobacter pylori actions, novel bismuth-based agents with broad antimicrobial activities against both Gram-positive and Gram-negative bacterial pathogens are highlighted. Intriguingly, bismuth-based combination therapy could effectively treat infections caused by antibiotic resistant superbugs. This chapter strives to offer an account of state-of-the-art research progress on antibacterial mechanisms of action of bismuth and explore the frontiers of up-to-date potential medicinal applications of bismuth-based agents with reference to recent developments in the literature.-
dc.languageeng-
dc.publisherAcademic Press-
dc.relation.ispartofAdvances in Inorganic Chemistry-
dc.subjectBismuth drug-
dc.subjectHelicobacter pylori-
dc.subjectAntimicrobial agent-
dc.subjectResistance breaker-
dc.titleBismuth drugs as antimicrobial agents-
dc.typeBook-
dc.identifier.emailWang, R: chemrmw@HKUCC-COM.hku.hk-
dc.identifier.emailLi, H: hylichem@hku.hk-
dc.identifier.emailSun, H: hsun@hku.hk-
dc.identifier.authoritySun, H=rp00777-
dc.identifier.doi10.1016/bs.adioch.2019.10.011-
dc.identifier.scopuseid_2-s2.0-85076219198-
dc.identifier.hkuros313758-
dc.identifier.volume75-
dc.identifier.spage183-
dc.identifier.epage205-
dc.publisher.placeCambridge, MA-

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