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Article: Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study

TitleRisk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study
Authors
KeywordsPregnancy
Venous thromboembolism
Chinese
Issue Date2019
PublisherKorean Society of Hematology. The Journal's web site is located at https://www.bloodresearch.or.kr/
Citation
Blood Research, 2019, v. 54 n. 3, p. 175-180 How to Cite?
AbstractBackground: Previous Caucasian studies have described venous thromboembolism in pregnancy; however, little is known about its incidence during pregnancy and early postpartum period in the Chinese population. We investigated the risk of venous thromboembolism in a “real-world” cohort of pregnant Chinese women with no prior history of venous thromboembolism. Methods: In this observational study, 15,325 pregnancies were identified in 14,162 Chinese women at Queen Mary Hospital, Hong Kong between January 2004 and September 2016. Demographic data, obstetric information, and laboratory and imaging data were retrieved and reviewed. Results: The mean age at pregnancy was 32.4±5.3 years, and the median age was 33 years (interquartile range, 29?36 yr). Pre-existing or newly diagnosed diabetes mellitus was present in 627 women (4.1%); 359 (0.7%) women had pre-existing or newly detected hypertension. There was a small number of women with pre-existing heart disease and/or rheumatic conditions. Most deliveries (86.0%) were normal vaginal; the remaining were Cesarean section 2,146 (14.0%). The incidence of venous thromboembolism was 0.4 per 1,000 pregnancies, of which 83.3% were deep vein thrombosis and 16.7% were pulmonary embolism. In contrast to previous studies, 66.7% of venous thrombosis occurred in the first trimester. Conclusion: Chinese women had a substantially lower risk of venous thromboembolism during pregnancy and the postpartum period compared to that of Caucasians. The occurrence of pregnancy-related venous thromboembolism was largely confined to the early pregnancy period, probably related to the adoption of thromboprophylaxis, a lower rate of Cesarean section, and early mobilization.
Persistent Identifierhttp://hdl.handle.net/10722/287158
ISSN
2015 SCImago Journal Rankings: 0.495
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHuang, D-
dc.contributor.authorWong, E-
dc.contributor.authorZuo, ML-
dc.contributor.authorChan, PH-
dc.contributor.authorYue, WS-
dc.contributor.authorHu, HX-
dc.contributor.authorChen, L-
dc.contributor.authorYin, LX-
dc.contributor.authorCui, XW-
dc.contributor.authorWu, MX-
dc.contributor.authorSu, X-
dc.contributor.authorSiu, CW-
dc.contributor.authorHai, JJ-
dc.date.accessioned2020-09-22T02:56:40Z-
dc.date.available2020-09-22T02:56:40Z-
dc.date.issued2019-
dc.identifier.citationBlood Research, 2019, v. 54 n. 3, p. 175-180-
dc.identifier.issn2287-979X-
dc.identifier.urihttp://hdl.handle.net/10722/287158-
dc.description.abstractBackground: Previous Caucasian studies have described venous thromboembolism in pregnancy; however, little is known about its incidence during pregnancy and early postpartum period in the Chinese population. We investigated the risk of venous thromboembolism in a “real-world” cohort of pregnant Chinese women with no prior history of venous thromboembolism. Methods: In this observational study, 15,325 pregnancies were identified in 14,162 Chinese women at Queen Mary Hospital, Hong Kong between January 2004 and September 2016. Demographic data, obstetric information, and laboratory and imaging data were retrieved and reviewed. Results: The mean age at pregnancy was 32.4±5.3 years, and the median age was 33 years (interquartile range, 29?36 yr). Pre-existing or newly diagnosed diabetes mellitus was present in 627 women (4.1%); 359 (0.7%) women had pre-existing or newly detected hypertension. There was a small number of women with pre-existing heart disease and/or rheumatic conditions. Most deliveries (86.0%) were normal vaginal; the remaining were Cesarean section 2,146 (14.0%). The incidence of venous thromboembolism was 0.4 per 1,000 pregnancies, of which 83.3% were deep vein thrombosis and 16.7% were pulmonary embolism. In contrast to previous studies, 66.7% of venous thrombosis occurred in the first trimester. Conclusion: Chinese women had a substantially lower risk of venous thromboembolism during pregnancy and the postpartum period compared to that of Caucasians. The occurrence of pregnancy-related venous thromboembolism was largely confined to the early pregnancy period, probably related to the adoption of thromboprophylaxis, a lower rate of Cesarean section, and early mobilization.-
dc.languageeng-
dc.publisherKorean Society of Hematology. The Journal's web site is located at https://www.bloodresearch.or.kr/-
dc.relation.ispartofBlood Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectPregnancy-
dc.subjectVenous thromboembolism-
dc.subjectChinese-
dc.titleRisk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study-
dc.typeArticle-
dc.identifier.emailChan, PH: phmchan@hku.hk-
dc.identifier.emailSiu, CW: cwdsiu@hkucc.hku.hk-
dc.identifier.emailHai, JJ: haishjj@hku.hk-
dc.identifier.authorityChan, PH=rp01864-
dc.identifier.authoritySiu, CW=rp00534-
dc.identifier.authorityHai, JJ=rp02047-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5045/br.2019.54.3.175-
dc.identifier.pmid31730677-
dc.identifier.pmcidPMC6779932-
dc.identifier.scopuseid_2-s2.0-85074412938-
dc.identifier.hkuros314480-
dc.identifier.volume54-
dc.identifier.issue3-
dc.identifier.spage175-
dc.identifier.epage180-
dc.identifier.isiWOS:000488260900006-
dc.publisher.placeRepublic of Korea-
dc.identifier.issnl2287-979X-

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