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Conference Paper: Clinico-pathological Features and Treatment Patterns of Primary Breast Cancer in Older Women in Hong Kong, with Comparison to Their Younger Counterparts

TitleClinico-pathological Features and Treatment Patterns of Primary Breast Cancer in Older Women in Hong Kong, with Comparison to Their Younger Counterparts
Authors
KeywordsBreast cancer
pathology
breast cancer specific survival
overall survival
Issue Date2019
PublisherElsevier Inc. The Journal's web site is located at http://www.geriatriconcology.net/
Citation
The 19th Annual Conference of the International Society of Geriatric Oncology (SIOG 2019), Geneva, Switzerland, 14-16 November 2019. In Journal of Geriatric Oncology, 2019, v. 10 n. 6, Suppl. 1, p. S52 How to Cite?
AbstractIntroduction: Breast cancer in older women is frequently considered less aggressive when compared with that in younger women. Objectives: To compare the clinico-pathological features and treatment patterns in two age groups (age ≥70 and <70). Methods: As part of a UK-Hong Kong research program on the effect of age and ethnicity on biology and clinical outcome of breast cancer, we retrospectively reviewed a consecutive series of Chinese female patients, with available surgical tumor samples, T1-4N0-2M0 breast carcinoma treated with primary surgery, between 2000-2005, and referred for adjuvant treatment and follow up at the Departments of Clinical Oncology of two teaching hospitals (Queen Mary Hospital and Pamela Youde Nethersole Eastern Hospital) in Hong Kong. Results: Total 783 patients were included (20% aged ≥70; 80% <70) with a mean follow-up of 132 months. No differences were seen in T and N stages, ER/PR and HER-2 status in both age groups. More older patients underwent mastectomy (87.3% versus 80.4%, p=0.046), with no differences seen in the type of axillary surgery. Adjuvant chemotherapy (8.9% versus 58.2%, p<0.0001) and radiotherapy (30.0% versus 57.1%, p<0.0001) were less often used in the older age group. At 10 years, there remained no difference in local or distant recurrences between the two groups. Both of which had similar breast cancer specifi c survival (BCSS) (older versus younger: 76.8% versus 77.9%, p=0.285). The older group had a shorter overall survival (OS) (51.1% versus 75.6%, p<0.001). Conclusions: Some differences in treatment pattern have been observed between the two groups. The difference in OS in the older population may in part be explained by competing causes of death. The lack of differences in clinico-pathological features and BCSS compared to what is often seen in the Western literature, suggests there may be possible differences in tumor biology in Chinese breast cancer. Further work is ongoing to investigate this.
DescriptionPoster Presentations - no. P040
Persistent Identifierhttp://hdl.handle.net/10722/287794
ISSN
2019 Impact Factor: 2.761
2015 SCImago Journal Rankings: 1.092

 

DC FieldValueLanguage
dc.contributor.authorChan, WLW-
dc.contributor.authorKhoo, US-
dc.contributor.authorSoong, I-
dc.contributor.authorHioe, M-
dc.contributor.authorWong, LS-
dc.contributor.authorChan, SYA-
dc.contributor.authorLuk, MY-
dc.contributor.authorCheung, KL-
dc.date.accessioned2020-10-05T12:03:23Z-
dc.date.available2020-10-05T12:03:23Z-
dc.date.issued2019-
dc.identifier.citationThe 19th Annual Conference of the International Society of Geriatric Oncology (SIOG 2019), Geneva, Switzerland, 14-16 November 2019. In Journal of Geriatric Oncology, 2019, v. 10 n. 6, Suppl. 1, p. S52-
dc.identifier.issn1879-4068-
dc.identifier.urihttp://hdl.handle.net/10722/287794-
dc.descriptionPoster Presentations - no. P040-
dc.description.abstractIntroduction: Breast cancer in older women is frequently considered less aggressive when compared with that in younger women. Objectives: To compare the clinico-pathological features and treatment patterns in two age groups (age ≥70 and <70). Methods: As part of a UK-Hong Kong research program on the effect of age and ethnicity on biology and clinical outcome of breast cancer, we retrospectively reviewed a consecutive series of Chinese female patients, with available surgical tumor samples, T1-4N0-2M0 breast carcinoma treated with primary surgery, between 2000-2005, and referred for adjuvant treatment and follow up at the Departments of Clinical Oncology of two teaching hospitals (Queen Mary Hospital and Pamela Youde Nethersole Eastern Hospital) in Hong Kong. Results: Total 783 patients were included (20% aged ≥70; 80% <70) with a mean follow-up of 132 months. No differences were seen in T and N stages, ER/PR and HER-2 status in both age groups. More older patients underwent mastectomy (87.3% versus 80.4%, p=0.046), with no differences seen in the type of axillary surgery. Adjuvant chemotherapy (8.9% versus 58.2%, p<0.0001) and radiotherapy (30.0% versus 57.1%, p<0.0001) were less often used in the older age group. At 10 years, there remained no difference in local or distant recurrences between the two groups. Both of which had similar breast cancer specifi c survival (BCSS) (older versus younger: 76.8% versus 77.9%, p=0.285). The older group had a shorter overall survival (OS) (51.1% versus 75.6%, p<0.001). Conclusions: Some differences in treatment pattern have been observed between the two groups. The difference in OS in the older population may in part be explained by competing causes of death. The lack of differences in clinico-pathological features and BCSS compared to what is often seen in the Western literature, suggests there may be possible differences in tumor biology in Chinese breast cancer. Further work is ongoing to investigate this.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.geriatriconcology.net/-
dc.relation.ispartofJournal of Geriatric Oncology-
dc.relation.ispartofInternational Society of Geriatric Oncology (SIOG) Annual Meeting-
dc.subjectBreast cancer-
dc.subjectpathology-
dc.subjectbreast cancer specific survival-
dc.subjectoverall survival-
dc.titleClinico-pathological Features and Treatment Patterns of Primary Breast Cancer in Older Women in Hong Kong, with Comparison to Their Younger Counterparts-
dc.typeConference_Paper-
dc.identifier.emailChan, WLW: winglok@hku.hk-
dc.identifier.emailLuk, MY: myluk@hkucc.hku.hk-
dc.identifier.authorityChan, WLW=rp02541-
dc.description.natureabstract-
dc.identifier.doi10.1016/S1879-4068(19)31204-4-
dc.identifier.hkuros314763-
dc.identifier.volume10-
dc.identifier.issue6, Suppl. 1-
dc.identifier.spageS52-
dc.identifier.epageS52-
dc.publisher.placeUnited States-

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