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Conference Paper: Bariatric surgery and risks of renal diseases, cardiovascular diseases and mortality among patients with type 2 diabetes mellitus

TitleBariatric surgery and risks of renal diseases, cardiovascular diseases and mortality among patients with type 2 diabetes mellitus
Authors
Issue Date2020
PublisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/
Citation
57th European Renal Association and European Dialysis and Transplant Association (ERA-EDTA) Congress, 6-9 June 2020. 57th ERA-EDTA Congress Abstracts in Nephrology Dialysis Transplantation, 2020, v. 35 n. Suppl. 3, p. iii1363, abstract no. P1039 How to Cite?
AbstractBackground and Aims: To measure and compare the risks of end-stage renal diseases (ESRD), cardiovascular diseases (CVD), all-cause mortality between obese type 2 diabetes mellitus (T2DM) patients with and without bariatric surgery. Method: A retrospective population-based cohort of 1,690 obese T2DM patients who were free of ESRD and CVD were assembled based on 2006-2017 Hospital Authority database. One-to-five propensity-score matching was used to balance baseline covariates between patients in bariatric surgery and control groups. Incidence rates (IR) of stage 4/5 chronic renal diseases, ESRD, CVD and all-cause mortality events for two groups were calculated. Hazard ratios (HR) for stage 4/5 chronic renal diseases, ESRD, CVD events were assessed using Cox proportional hazard models. Changes in estimated glomerular filtration rate (eGFR), and urine albumin-creatinine ratio (UACR) were measured up to 60 months. Results: Over a mean follow-up period of 34 months with 863 person-years, cumulative incidences of mortality, stage 4/5 chronic kidney diseases, ESRD and CVD for surgical patients were 0, 0.050, 0.017, and 0.036, respectively. Surgical patients had reduced IR of all-cause mortality, stage 4/5 chronic kidney diseases, ESRD and CVD (IR=0, 1.784, 0.587 and 1.321 per 100 person-years, respectively) than control patients (IR=1.954, 2.028, 0.914 and 2.814 per 100 person-years, respectively). Surgery group had a significant reduction in risk of CVD events (HR=0.464, P=0.015), and no occurrence of mortality events. However, the IR of stage 4/5 chronic kidney diseases and ESRD of the two groups were not significantly different. Surgical patients had significantly higher eGFR within 12 months, and had significantly lower until 48 months. Conclusion: Among obese T2DM patients, bariatric surgery lowered the risk of CVD and mortality, and was beneficial towards the kidney outcomes of eGFR up to 36 months.
Persistent Identifierhttp://hdl.handle.net/10722/288391
ISSN
2019 Impact Factor: 4.531
2015 SCImago Journal Rankings: 1.780

 

DC FieldValueLanguage
dc.contributor.authorWong, CKH-
dc.contributor.authorWu, T-
dc.contributor.authorWong, SKH-
dc.contributor.authorLaw, TT-
dc.contributor.authorGrieve, E-
dc.contributor.authorWu, O-
dc.contributor.authorLam, CLK-
dc.date.accessioned2020-10-05T12:12:11Z-
dc.date.available2020-10-05T12:12:11Z-
dc.date.issued2020-
dc.identifier.citation57th European Renal Association and European Dialysis and Transplant Association (ERA-EDTA) Congress, 6-9 June 2020. 57th ERA-EDTA Congress Abstracts in Nephrology Dialysis Transplantation, 2020, v. 35 n. Suppl. 3, p. iii1363, abstract no. P1039-
dc.identifier.issn0931-0509-
dc.identifier.urihttp://hdl.handle.net/10722/288391-
dc.description.abstractBackground and Aims: To measure and compare the risks of end-stage renal diseases (ESRD), cardiovascular diseases (CVD), all-cause mortality between obese type 2 diabetes mellitus (T2DM) patients with and without bariatric surgery. Method: A retrospective population-based cohort of 1,690 obese T2DM patients who were free of ESRD and CVD were assembled based on 2006-2017 Hospital Authority database. One-to-five propensity-score matching was used to balance baseline covariates between patients in bariatric surgery and control groups. Incidence rates (IR) of stage 4/5 chronic renal diseases, ESRD, CVD and all-cause mortality events for two groups were calculated. Hazard ratios (HR) for stage 4/5 chronic renal diseases, ESRD, CVD events were assessed using Cox proportional hazard models. Changes in estimated glomerular filtration rate (eGFR), and urine albumin-creatinine ratio (UACR) were measured up to 60 months. Results: Over a mean follow-up period of 34 months with 863 person-years, cumulative incidences of mortality, stage 4/5 chronic kidney diseases, ESRD and CVD for surgical patients were 0, 0.050, 0.017, and 0.036, respectively. Surgical patients had reduced IR of all-cause mortality, stage 4/5 chronic kidney diseases, ESRD and CVD (IR=0, 1.784, 0.587 and 1.321 per 100 person-years, respectively) than control patients (IR=1.954, 2.028, 0.914 and 2.814 per 100 person-years, respectively). Surgery group had a significant reduction in risk of CVD events (HR=0.464, P=0.015), and no occurrence of mortality events. However, the IR of stage 4/5 chronic kidney diseases and ESRD of the two groups were not significantly different. Surgical patients had significantly higher eGFR within 12 months, and had significantly lower until 48 months. Conclusion: Among obese T2DM patients, bariatric surgery lowered the risk of CVD and mortality, and was beneficial towards the kidney outcomes of eGFR up to 36 months.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/-
dc.relation.ispartofNephrology Dialysis Transplantation-
dc.relation.ispartof57th ERA-EDTA Congress, 2020-
dc.titleBariatric surgery and risks of renal diseases, cardiovascular diseases and mortality among patients with type 2 diabetes mellitus-
dc.typeConference_Paper-
dc.identifier.emailWong, CKH: carlosho@hku.hk-
dc.identifier.emailLam, CLK: clklam@hku.hk-
dc.identifier.authorityWong, CKH=rp01931-
dc.identifier.authorityLam, CLK=rp00350-
dc.description.natureabstract-
dc.identifier.doi10.1093/ndt/gfaa142.P1039-
dc.identifier.hkuros314633-
dc.identifier.volume35-
dc.identifier.issueSuppl. 3-
dc.identifier.spageiii1363, abstract no. P1039-
dc.identifier.epageiii1363, abstract no. P1039-
dc.publisher.placeUnited Kingdom-

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