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Article: A Red Light‐Triggered Drug Release System Based on One‐Photon Upconversion‐Like Photolysis

TitleA Red Light‐Triggered Drug Release System Based on One‐Photon Upconversion‐Like Photolysis
Authors
Keywordsdrug release
long‐wavelength light triggering
photocleavages
photoresponsive nanoparticles
polymeric nanoparticles
Issue Date2020
PublisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=2192-2640
Citation
Advanced Healthcare Materials, 2020, v. 9 n. 21, p. article no. 2001118 How to Cite?
AbstractPhotoresponsive drug release systems can enhance drug accumulation at the sites where light is applied. Nowadays, the photocleavable groups used in the systems usually require ultraviolet or blue light irradiation, which limits tissue penetration depth and is harmful to normal cells and living bodies. A one‐photon upconversion‐like photolysis strategy, which can cleave green light‐activatable prodrugs with red light at the presence of a red light‐excitable photosensitizer in organic solvents, is developed. However, both the prodrug and photosensitizer are hydrophobic and their energy transfer process is sensitive to oxygen molecules. Here, a simple strategy to address these problems by loading the two components in biocompatible and biodegradable polymeric micelles, is presented. The developed low‐irradiance red light‐triggered drug release system has a size around 40 nm and exhibits good stability in aqueous solutions. The micellar encapsulation protects the photolysis reaction from oxygen quenching in normoxia aqueous solutions. The therapeutic effect of the system enhanced by the redlight irradiation is demonstrated through in vitro and in vivo studies, indicating promising potential in cancer therapy. The study provides the first example and also an important reference for applying one‐photon upconversion‐like photolysis in biomedical applications.
Persistent Identifierhttp://hdl.handle.net/10722/289254
ISSN
2020 Impact Factor: 9.933
2020 SCImago Journal Rankings: 2.288
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLyu, W-
dc.contributor.authorLONG, K-
dc.contributor.authorYang, Y-
dc.contributor.authorChen, S-
dc.contributor.authorZhan, C-
dc.contributor.authorWang, W-
dc.date.accessioned2020-10-22T08:10:03Z-
dc.date.available2020-10-22T08:10:03Z-
dc.date.issued2020-
dc.identifier.citationAdvanced Healthcare Materials, 2020, v. 9 n. 21, p. article no. 2001118-
dc.identifier.issn2192-2640-
dc.identifier.urihttp://hdl.handle.net/10722/289254-
dc.description.abstractPhotoresponsive drug release systems can enhance drug accumulation at the sites where light is applied. Nowadays, the photocleavable groups used in the systems usually require ultraviolet or blue light irradiation, which limits tissue penetration depth and is harmful to normal cells and living bodies. A one‐photon upconversion‐like photolysis strategy, which can cleave green light‐activatable prodrugs with red light at the presence of a red light‐excitable photosensitizer in organic solvents, is developed. However, both the prodrug and photosensitizer are hydrophobic and their energy transfer process is sensitive to oxygen molecules. Here, a simple strategy to address these problems by loading the two components in biocompatible and biodegradable polymeric micelles, is presented. The developed low‐irradiance red light‐triggered drug release system has a size around 40 nm and exhibits good stability in aqueous solutions. The micellar encapsulation protects the photolysis reaction from oxygen quenching in normoxia aqueous solutions. The therapeutic effect of the system enhanced by the redlight irradiation is demonstrated through in vitro and in vivo studies, indicating promising potential in cancer therapy. The study provides the first example and also an important reference for applying one‐photon upconversion‐like photolysis in biomedical applications.-
dc.languageeng-
dc.publisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=2192-2640-
dc.relation.ispartofAdvanced Healthcare Materials-
dc.rightsThis is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectdrug release-
dc.subjectlong‐wavelength light triggering-
dc.subjectphotocleavages-
dc.subjectphotoresponsive nanoparticles-
dc.subjectpolymeric nanoparticles-
dc.titleA Red Light‐Triggered Drug Release System Based on One‐Photon Upconversion‐Like Photolysis-
dc.typeArticle-
dc.identifier.emailLyu, W: lyuwen@hku.hk-
dc.identifier.emailWang, W: wangwp@hku.hk-
dc.identifier.authorityWang, W=rp02227-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/adhm.202001118-
dc.identifier.pmid32985134-
dc.identifier.scopuseid_2-s2.0-85091484590-
dc.identifier.hkuros315986-
dc.identifier.volume9-
dc.identifier.issue21-
dc.identifier.spagearticle no. 2001118-
dc.identifier.epagearticle no. 2001118-
dc.identifier.isiWOS:000572949500001-
dc.publisher.placeGermany-
dc.identifier.issnl2192-2640-

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