File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A Decade of Progress in Deep Brain Stimulation of the Subcallosal Cingulate for the Treatment of Depression

TitleA Decade of Progress in Deep Brain Stimulation of the Subcallosal Cingulate for the Treatment of Depression
Authors
Issue Date2020
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/jcm
Citation
Journal of Clinical Medicine, 2020, v. 9 n. 10, p. article no. 3260 How to Cite?
AbstractMajor depression contributes significantly to the global disability burden. Since the first clinical study of deep brain stimulation (DBS), over 406 patients with depression have now undergone this neuromodulation therapy, and 30 animal studies have investigated the efficacy of subgenual cingulate DBS for depression. In this review, we aim to provide a comprehensive overview of the progress of DBS of the subcallosal cingulate in humans and the medial prefrontal cortex, its rodent homolog. For preclinical animal studies, we discuss the various antidepressant-like behaviors induced by medial prefrontal cortex DBS and examine the possible mechanisms including neuroplasticity-dependent/independent cellular and molecular changes. Interestingly, the response rate of subcallosal cingulate Deep brain stimulation marks a milestone in the treatment of depression. DBS among patients with treatment-resistant depression was estimated to be approximately 54% across clinical studies. Although some studies showed its stimulation efficacy was limited, it still holds great promise as a therapy for patients with treatment-resistant depression. Overall, further research is still needed, including more credible clinical research, preclinical mechanistic studies, precise selection of patients, and customized electrical stimulation paradigms.
Persistent Identifierhttp://hdl.handle.net/10722/289585
ISSN
2018 Impact Factor: 5.688
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorMUHAMMAD SHARAFUDDIN BIN, MK-
dc.contributor.authorNgo, FY-
dc.contributor.authorLim, WL-
dc.contributor.authorAquili, L-
dc.contributor.authorKhan, NA-
dc.contributor.authorFung, ML-
dc.contributor.authorChan, YS-
dc.contributor.authorTemel, Y-
dc.contributor.authorLim, LW-
dc.date.accessioned2020-10-22T08:14:42Z-
dc.date.available2020-10-22T08:14:42Z-
dc.date.issued2020-
dc.identifier.citationJournal of Clinical Medicine, 2020, v. 9 n. 10, p. article no. 3260-
dc.identifier.issn2077-0383-
dc.identifier.urihttp://hdl.handle.net/10722/289585-
dc.description.abstractMajor depression contributes significantly to the global disability burden. Since the first clinical study of deep brain stimulation (DBS), over 406 patients with depression have now undergone this neuromodulation therapy, and 30 animal studies have investigated the efficacy of subgenual cingulate DBS for depression. In this review, we aim to provide a comprehensive overview of the progress of DBS of the subcallosal cingulate in humans and the medial prefrontal cortex, its rodent homolog. For preclinical animal studies, we discuss the various antidepressant-like behaviors induced by medial prefrontal cortex DBS and examine the possible mechanisms including neuroplasticity-dependent/independent cellular and molecular changes. Interestingly, the response rate of subcallosal cingulate Deep brain stimulation marks a milestone in the treatment of depression. DBS among patients with treatment-resistant depression was estimated to be approximately 54% across clinical studies. Although some studies showed its stimulation efficacy was limited, it still holds great promise as a therapy for patients with treatment-resistant depression. Overall, further research is still needed, including more credible clinical research, preclinical mechanistic studies, precise selection of patients, and customized electrical stimulation paradigms.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/jcm-
dc.relation.ispartofJournal of Clinical Medicine-
dc.titleA Decade of Progress in Deep Brain Stimulation of the Subcallosal Cingulate for the Treatment of Depression-
dc.typeArticle-
dc.identifier.emailFung, ML: fungml@hku.hk-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.authorityFung, ML=rp00433-
dc.identifier.authorityChan, YS=rp00318-
dc.identifier.authorityLim, LW=rp02088-
dc.identifier.doi10.3390/jcm9103260-
dc.identifier.pmid33053848-
dc.identifier.pmcidPMC7601903-
dc.identifier.hkuros316176-
dc.identifier.volume9-
dc.identifier.issue10-
dc.identifier.spagearticle no. 3260-
dc.identifier.epagearticle no. 3260-
dc.publisher.placeSwitzerland-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats