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Article: Artificial intelligence mobile health platform for early detection of COVID-19 in quarantine subjects using a wearable biosensor: protocol for a randomised controlled trial

TitleArtificial intelligence mobile health platform for early detection of COVID-19 in quarantine subjects using a wearable biosensor: protocol for a randomised controlled trial
Authors
Keywordsinfection controlt
elemedicine
virology
Issue Date2020
PublisherBMJ Publishing Group: BMJ Open. The Journal's web site is located at http://bmjopen.bmj.com
Citation
BMJ Open, 2020, v. 10 n. 7, p. article no. e038555 How to Cite?
AbstractIntroduction: There is an outbreak of COVID-19 worldwide. As there is no effective therapy or vaccine yet, rigorous implementation of traditional public health measures such as isolation and quarantine remains the most effective tool to control the outbreak. When an asymptomatic individual with COVID-19 exposure is being quarantined, it is necessary to perform temperature and symptom surveillance. As such surveillance is intermittent in nature and highly dependent on self-discipline, it has limited effectiveness. Advances in biosensor technologies made it possible to continuously monitor physiological parameters using wearable biosensors with a variety of form factors. Objective: To explore the potential of using wearable biosensors to continuously monitor multidimensional physiological parameters for early detection of COVID-19 clinical progression. Method: This randomised controlled open-labelled trial will involve 200–1000 asymptomatic subjects with close COVID-19 contact under mandatory quarantine at designated facilities in Hong Kong. Subjects will be randomised to receive a remote monitoring strategy (intervention group) or standard strategy (control group) in a 1:1 ratio during the 14 day-quarantine period. In addition to fever and symptom surveillance in the control group, subjects in the intervention group will wear wearable biosensors on their arms to continuously monitor skin temperature, respiratory rate, blood pressure, pulse rate, blood oxygen saturation and daily activities. These physiological parameters will be transferred in real time to a smartphone application called Biovitals Sentinel. These data will then be processed using a cloud-based multivariate physiology analytics engine called Biovitals to detect subtle physiological changes. The results will be displayed on a web-based dashboard for clinicians’ review. The primary outcome is the time to diagnosis of COVID-19. Ethics and dissemination: Ethical approval has been obtained from institutional review boards at the study sites. Results will be published in peer-reviewed journals.
Persistent Identifierhttp://hdl.handle.net/10722/289783
ISSN
2020 Impact Factor: 2.692
2020 SCImago Journal Rankings: 1.132
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorWong, CK-
dc.contributor.authorHo, DTY-
dc.contributor.authorTam, AR-
dc.contributor.authorZhou, M-
dc.contributor.authorLau, YM-
dc.contributor.authorTang, MOY-
dc.contributor.authorTong, RCF-
dc.contributor.authorRajput, KS-
dc.contributor.authorChen, G-
dc.contributor.authorChan, SC-
dc.contributor.authorSiu, CW-
dc.contributor.authorHung, IFN-
dc.date.accessioned2020-10-22T08:17:25Z-
dc.date.available2020-10-22T08:17:25Z-
dc.date.issued2020-
dc.identifier.citationBMJ Open, 2020, v. 10 n. 7, p. article no. e038555-
dc.identifier.issn2044-6055-
dc.identifier.urihttp://hdl.handle.net/10722/289783-
dc.description.abstractIntroduction: There is an outbreak of COVID-19 worldwide. As there is no effective therapy or vaccine yet, rigorous implementation of traditional public health measures such as isolation and quarantine remains the most effective tool to control the outbreak. When an asymptomatic individual with COVID-19 exposure is being quarantined, it is necessary to perform temperature and symptom surveillance. As such surveillance is intermittent in nature and highly dependent on self-discipline, it has limited effectiveness. Advances in biosensor technologies made it possible to continuously monitor physiological parameters using wearable biosensors with a variety of form factors. Objective: To explore the potential of using wearable biosensors to continuously monitor multidimensional physiological parameters for early detection of COVID-19 clinical progression. Method: This randomised controlled open-labelled trial will involve 200–1000 asymptomatic subjects with close COVID-19 contact under mandatory quarantine at designated facilities in Hong Kong. Subjects will be randomised to receive a remote monitoring strategy (intervention group) or standard strategy (control group) in a 1:1 ratio during the 14 day-quarantine period. In addition to fever and symptom surveillance in the control group, subjects in the intervention group will wear wearable biosensors on their arms to continuously monitor skin temperature, respiratory rate, blood pressure, pulse rate, blood oxygen saturation and daily activities. These physiological parameters will be transferred in real time to a smartphone application called Biovitals Sentinel. These data will then be processed using a cloud-based multivariate physiology analytics engine called Biovitals to detect subtle physiological changes. The results will be displayed on a web-based dashboard for clinicians’ review. The primary outcome is the time to diagnosis of COVID-19. Ethics and dissemination: Ethical approval has been obtained from institutional review boards at the study sites. Results will be published in peer-reviewed journals.-
dc.languageeng-
dc.publisherBMJ Publishing Group: BMJ Open. The Journal's web site is located at http://bmjopen.bmj.com-
dc.relation.ispartofBMJ Open-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectinfection controlt-
dc.subjectelemedicine-
dc.subjectvirology-
dc.titleArtificial intelligence mobile health platform for early detection of COVID-19 in quarantine subjects using a wearable biosensor: protocol for a randomised controlled trial-
dc.typeArticle-
dc.identifier.emailHo, DTY: tipyinho@hku.hk-
dc.identifier.emailTang, MOY: medtoy@hku.hk-
dc.identifier.emailSiu, CW: cwdsiu@hkucc.hku.hk-
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hk-
dc.identifier.authoritySiu, CW=rp00534-
dc.identifier.authorityHung, IFN=rp00508-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1136/bmjopen-2020-038555-
dc.identifier.pmid32699167-
dc.identifier.pmcidPMC7380847-
dc.identifier.scopuseid_2-s2.0-85088436093-
dc.identifier.hkuros317177-
dc.identifier.volume10-
dc.identifier.issue7-
dc.identifier.spagearticle no. e038555-
dc.identifier.epagearticle no. e038555-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl2044-6055-

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