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Conference Paper: Survival after liver transplant in recipients of different age groups: a systematic review and meta-analysis

TitleSurvival after liver transplant in recipients of different age groups: a systematic review and meta-analysis
Authors
Issue Date2020
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
Citation
Digital International Liver Congress (Digital ILC 2020), 27-29 August 2020. In Journal of Hepatology, 2020, v. 73 n. Suppl. 1, p. S263-S264 How to Cite?
AbstractBackground and Aims: An increasing number of elderly patients are undergoing liver transplantation for end-stage liver disease and hepatocellular carcinoma. However, there is a paucity of data on the risk of mortality post-liver transplantation with respect to increasing age. Method: We performed a systematic review and meta-analysis to assess the effect of older age on mortality after liver transplantation. A comprehensive literature review was conducted utilizing the PUBMED, MEDLINE, SCOPUS and EMBASE databases through July 2019 to identify all cohort studies that compared the long-term survival outcome between patients who underwent liver transplantation at the age of older recipients versus younger recipients. Effect estimates from each study were extracted and combined using the random-effect. Results: Of 686 potentially eligible articles, a total of 20 studies with 19,412 participants fulfilled the eligibility criteria and were included in the meta-analysis. With respect to transplant mortality, subgroup analysis showed age ≥70 years compared to younger recipients had the pooled RR of 1.62 (95% CI, 1.49–1.77, p < 0.0001) (Figure); age ≥60 years compared to younger recipients had the pooled RR of 1.18 (95% CI, 0.96–1.44, p = 0.11) and age ≥50 years compared to younger recipients had the pooled RR of 1.44 (95% CI, 1.07–1.96, =0.02) (Figure). Between-group comparisons, recipients age ≥70 years were significantly increase risk of mortality post-liver transplantation ( p = 0.01). Conclusion: There was a significantly increased risk of mortality post-liver transplantation among recipients age ≥70 years. This suggests that the age of 70 years could be the deflection point where the rate of mortality starts to accelerate, with risks outweighing benefits beyond this age group.
DescriptionPoster presentation - Liver transplantation and hepatobiliary surgery: Clinical aspects - no. THU250
Persistent Identifierhttp://hdl.handle.net/10722/289893
ISSN
2019 Impact Factor: 20.582
2015 SCImago Journal Rankings: 4.570

 

DC FieldValueLanguage
dc.contributor.authorCheng, HM-
dc.contributor.authorSeto, WKW-
dc.contributor.authorCheng, CKK-
dc.contributor.authorChan, ACY-
dc.contributor.authorYuen, RMF-
dc.contributor.authorFung, JYY-
dc.date.accessioned2020-10-22T08:18:58Z-
dc.date.available2020-10-22T08:18:58Z-
dc.date.issued2020-
dc.identifier.citationDigital International Liver Congress (Digital ILC 2020), 27-29 August 2020. In Journal of Hepatology, 2020, v. 73 n. Suppl. 1, p. S263-S264-
dc.identifier.issn0168-8278-
dc.identifier.urihttp://hdl.handle.net/10722/289893-
dc.descriptionPoster presentation - Liver transplantation and hepatobiliary surgery: Clinical aspects - no. THU250-
dc.description.abstractBackground and Aims: An increasing number of elderly patients are undergoing liver transplantation for end-stage liver disease and hepatocellular carcinoma. However, there is a paucity of data on the risk of mortality post-liver transplantation with respect to increasing age. Method: We performed a systematic review and meta-analysis to assess the effect of older age on mortality after liver transplantation. A comprehensive literature review was conducted utilizing the PUBMED, MEDLINE, SCOPUS and EMBASE databases through July 2019 to identify all cohort studies that compared the long-term survival outcome between patients who underwent liver transplantation at the age of older recipients versus younger recipients. Effect estimates from each study were extracted and combined using the random-effect. Results: Of 686 potentially eligible articles, a total of 20 studies with 19,412 participants fulfilled the eligibility criteria and were included in the meta-analysis. With respect to transplant mortality, subgroup analysis showed age ≥70 years compared to younger recipients had the pooled RR of 1.62 (95% CI, 1.49–1.77, p < 0.0001) (Figure); age ≥60 years compared to younger recipients had the pooled RR of 1.18 (95% CI, 0.96–1.44, p = 0.11) and age ≥50 years compared to younger recipients had the pooled RR of 1.44 (95% CI, 1.07–1.96, =0.02) (Figure). Between-group comparisons, recipients age ≥70 years were significantly increase risk of mortality post-liver transplantation ( p = 0.01). Conclusion: There was a significantly increased risk of mortality post-liver transplantation among recipients age ≥70 years. This suggests that the age of 70 years could be the deflection point where the rate of mortality starts to accelerate, with risks outweighing benefits beyond this age group.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep-
dc.relation.ispartofJournal of Hepatology-
dc.relation.ispartofDigital International Liver Congress (Digital ILC 2020)-
dc.titleSurvival after liver transplant in recipients of different age groups: a systematic review and meta-analysis-
dc.typeConference_Paper-
dc.identifier.emailCheng, HM: hmcheng@hku.hk-
dc.identifier.emailSeto, WKW: wkseto@hku.hk-
dc.identifier.emailChan, ACY: acchan@hku.hk-
dc.identifier.emailYuen, RMF: mfyuen@hku.hk-
dc.identifier.emailFung, JYY: jfung@hkucc.hku.hk-
dc.identifier.authoritySeto, WKW=rp01659-
dc.identifier.authorityChan, ACY=rp00310-
dc.identifier.authorityYuen, RMF=rp00479-
dc.identifier.authorityFung, JYY=rp00518-
dc.description.natureabstract-
dc.identifier.doi10.1016/S0168-8278(20)31030-8-
dc.identifier.hkuros315875-
dc.identifier.volume73-
dc.identifier.issueSuppl. 1-
dc.identifier.spageS263-
dc.identifier.epageS264-
dc.publisher.placeNetherlands-

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