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- Publisher Website: 10.1002/anie.201812982
- Scopus: eid_2-s2.0-85069909396
- PMID: 30793459
- WOS: WOS:000476318300001
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Article: Chemical Syntheses and Chemical Biology of Carboxyl Polyether Ionophores: Recent Highlights
Title | Chemical Syntheses and Chemical Biology of Carboxyl Polyether Ionophores: Recent Highlights |
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Authors | |
Keywords | chemical biology carboxyl polyether ionophores natural products total synthesis |
Issue Date | 2019 |
Citation | Angewandte Chemie - International Edition, 2019, v. 58, n. 39, p. 13630-13642 How to Cite? |
Abstract | © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim A central goal of chemical biology is to develop molecular probes that enable fundamental studies of cellular systems. In the hierarchy of bioactive molecules, the so-called ionophore class occupies an unflattering position in the lower branches, with typical labels being “non-specific” and “toxic”. In fact, the mere possibility that a candidate molecule possesses “ionophore activity” typically prompts its removal from further studies; ionophores—from a chemical genetics perspective—are molecular outlaws. In stark contrast to this overall poor reputation of ionophores, synthetic chemistry owes some of its most amazing achievements to studies of ionophore natural products, in particular the carboxyl polyethers renowned for their intricate molecular structures. These compounds have for decades been academic battlegrounds where new synthetic methodology is tested and retrosynthetic tactics perfected. Herein, we review the most exciting recent advances in carboxyl polyether ionophore (CPI) synthesis and in addition discuss the burgeoning field of CPI chemical biology. |
Persistent Identifier | http://hdl.handle.net/10722/292121 |
ISSN | 2021 Impact Factor: 16.823 2020 SCImago Journal Rankings: 5.831 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, Han | - |
dc.contributor.author | Lin, Shaoquan | - |
dc.contributor.author | Jacobsen, Kristian M. | - |
dc.contributor.author | Poulsen, Thomas B. | - |
dc.date.accessioned | 2020-11-17T14:55:48Z | - |
dc.date.available | 2020-11-17T14:55:48Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Angewandte Chemie - International Edition, 2019, v. 58, n. 39, p. 13630-13642 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292121 | - |
dc.description.abstract | © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim A central goal of chemical biology is to develop molecular probes that enable fundamental studies of cellular systems. In the hierarchy of bioactive molecules, the so-called ionophore class occupies an unflattering position in the lower branches, with typical labels being “non-specific” and “toxic”. In fact, the mere possibility that a candidate molecule possesses “ionophore activity” typically prompts its removal from further studies; ionophores—from a chemical genetics perspective—are molecular outlaws. In stark contrast to this overall poor reputation of ionophores, synthetic chemistry owes some of its most amazing achievements to studies of ionophore natural products, in particular the carboxyl polyethers renowned for their intricate molecular structures. These compounds have for decades been academic battlegrounds where new synthetic methodology is tested and retrosynthetic tactics perfected. Herein, we review the most exciting recent advances in carboxyl polyether ionophore (CPI) synthesis and in addition discuss the burgeoning field of CPI chemical biology. | - |
dc.language | eng | - |
dc.relation.ispartof | Angewandte Chemie - International Edition | - |
dc.subject | chemical biology | - |
dc.subject | carboxyl polyether ionophores | - |
dc.subject | natural products | - |
dc.subject | total synthesis | - |
dc.title | Chemical Syntheses and Chemical Biology of Carboxyl Polyether Ionophores: Recent Highlights | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/anie.201812982 | - |
dc.identifier.pmid | 30793459 | - |
dc.identifier.scopus | eid_2-s2.0-85069909396 | - |
dc.identifier.volume | 58 | - |
dc.identifier.issue | 39 | - |
dc.identifier.spage | 13630 | - |
dc.identifier.epage | 13642 | - |
dc.identifier.eissn | 1521-3773 | - |
dc.identifier.isi | WOS:000476318300001 | - |
dc.identifier.issnl | 1433-7851 | - |