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Article: Continental-scale pollution of estuaries with antibiotic resistance genes

TitleContinental-scale pollution of estuaries with antibiotic resistance genes
Authors
Issue Date2017
Citation
Nature Microbiology, 2017, v. 2 n. 4, p. 16270 How to Cite?
AbstractAntibiotic resistance genes (ARGs) have moved from the environmental resistome into human commensals and pathogens, driven by human selection with antimicrobial agents. These genes have increased in abundance in humans and domestic animals, to become common components of waste streams. Estuarine habitats lie between terrestrial/freshwater and marine ecosystems, acting as natural filtering points for pollutants. Here, we have profiled ARGs in sediments from 18 estuaries over 4,000 km of coastal China using high-throughput quantitative polymerase chain reaction, and investigated their relationship with bacterial communities, antibiotic residues and socio-economic factors. ARGs in estuarine sediments were diverse and abundant, with over 200 different resistance genes being detected, 18 of which were found in all 90 sediment samples. The strong correlations of identified resistance genes with known mobile elements, network analyses and partial redundancy analysis all led to the conclusion that human activity is responsible for the abundance and dissemination of these ARGs. Such widespread pollution with xenogenetic elements has environmental, agricultural and medical consequences.
Persistent Identifierhttp://hdl.handle.net/10722/293740
ISSN
2019 Impact Factor: 15.54

 

DC FieldValueLanguage
dc.contributor.authorZhu, Y-
dc.contributor.authorZhao, Y-
dc.contributor.authorLi, B-
dc.contributor.authorHuang, C-
dc.contributor.authorZhang, S-
dc.contributor.authorYu, S-
dc.contributor.authorChen, Y-
dc.contributor.authorZhang, T-
dc.contributor.authorGillings, MR-
dc.contributor.authorSu, J-
dc.date.accessioned2020-11-23T08:21:08Z-
dc.date.available2020-11-23T08:21:08Z-
dc.date.issued2017-
dc.identifier.citationNature Microbiology, 2017, v. 2 n. 4, p. 16270-
dc.identifier.issn2058-5276-
dc.identifier.urihttp://hdl.handle.net/10722/293740-
dc.description.abstractAntibiotic resistance genes (ARGs) have moved from the environmental resistome into human commensals and pathogens, driven by human selection with antimicrobial agents. These genes have increased in abundance in humans and domestic animals, to become common components of waste streams. Estuarine habitats lie between terrestrial/freshwater and marine ecosystems, acting as natural filtering points for pollutants. Here, we have profiled ARGs in sediments from 18 estuaries over 4,000 km of coastal China using high-throughput quantitative polymerase chain reaction, and investigated their relationship with bacterial communities, antibiotic residues and socio-economic factors. ARGs in estuarine sediments were diverse and abundant, with over 200 different resistance genes being detected, 18 of which were found in all 90 sediment samples. The strong correlations of identified resistance genes with known mobile elements, network analyses and partial redundancy analysis all led to the conclusion that human activity is responsible for the abundance and dissemination of these ARGs. Such widespread pollution with xenogenetic elements has environmental, agricultural and medical consequences.-
dc.languageeng-
dc.relation.ispartofNature Microbiology-
dc.titleContinental-scale pollution of estuaries with antibiotic resistance genes-
dc.typeArticle-
dc.identifier.emailZhang, T: zhangt@hkucc.hku.hk-
dc.identifier.authorityZhang, T=rp00211-
dc.identifier.doi10.1038/nmicrobiol.2016.270-
dc.identifier.hkuros319383-
dc.identifier.volume2-
dc.identifier.issue4-
dc.identifier.spage16270-
dc.identifier.epage16270-

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