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Book Chapter: Polarization of tumour-associated macrophages by Chinese medicine intervention: mechanisms and applications

TitlePolarization of tumour-associated macrophages by Chinese medicine intervention: mechanisms and applications
Authors
Keywordstumor microenvironment
tumor-associated macrophage
polarization
Chinese medicine
Issue Date2020
PublisherIntechOpen
Citation
Polarization of tumour-associated macrophages by Chinese medicine intervention: mechanisms and applications. In Bhat, KH (Ed.), Macrophage Activation: Biology and Disease. London: IntechOpen, 2020 How to Cite?
AbstractMacrophage polarization is a spectrum of phenotypes and generally can be classified into two states: (1) classically activated or M1 macrophages, which can be driven by lipopolysaccharide (LPS) alone or in association with Th1 cytokines and produce pro-inflammatory cytokines such as TNF-α, IL-6 and, IL-12, and (2) alternatively activated M2 macrophages, which can be promoted by Th2 mediators IL-4 and IL-13 and produce anti-inflammatory cytokines such as TGF-β and IL-10. Current studies have found that the phenotypic switch between M1 and M2 macrophages governs the fate of an organ in inflammation or injury. The imbalance of M1/M2 polarization is closely involved in various pathological processes and is becoming a potential target for therapeutic strategies. Traditional Chinese medicine is an integrated healthcare system composed of many practices and is characterized by multi-target, multi-level, and coordinated intervention effects. Chinese medicines nowadays are applied to regulate phenotype polarization of macrophages to improve the microenvironment, thus ameliorating or even eliminating the symptoms. In this chapter, we will discuss the molecular mechanisms of macrophage polarization, their roles in health and disease, and the intervention with Chinese medicines to modulate the polarization of macrophages in tumor microenvironment (TME) for therapeutic purpose.
Persistent Identifierhttp://hdl.handle.net/10722/293839
ISBN

 

DC FieldValueLanguage
dc.contributor.authorLu, Y-
dc.contributor.authorTan, HYH-
dc.contributor.authorWang, N-
dc.contributor.authorFeng, Y-
dc.date.accessioned2020-11-23T08:22:32Z-
dc.date.available2020-11-23T08:22:32Z-
dc.date.issued2020-
dc.identifier.citationPolarization of tumour-associated macrophages by Chinese medicine intervention: mechanisms and applications. In Bhat, KH (Ed.), Macrophage Activation: Biology and Disease. London: IntechOpen, 2020-
dc.identifier.isbn9781789846447-
dc.identifier.urihttp://hdl.handle.net/10722/293839-
dc.description.abstractMacrophage polarization is a spectrum of phenotypes and generally can be classified into two states: (1) classically activated or M1 macrophages, which can be driven by lipopolysaccharide (LPS) alone or in association with Th1 cytokines and produce pro-inflammatory cytokines such as TNF-α, IL-6 and, IL-12, and (2) alternatively activated M2 macrophages, which can be promoted by Th2 mediators IL-4 and IL-13 and produce anti-inflammatory cytokines such as TGF-β and IL-10. Current studies have found that the phenotypic switch between M1 and M2 macrophages governs the fate of an organ in inflammation or injury. The imbalance of M1/M2 polarization is closely involved in various pathological processes and is becoming a potential target for therapeutic strategies. Traditional Chinese medicine is an integrated healthcare system composed of many practices and is characterized by multi-target, multi-level, and coordinated intervention effects. Chinese medicines nowadays are applied to regulate phenotype polarization of macrophages to improve the microenvironment, thus ameliorating or even eliminating the symptoms. In this chapter, we will discuss the molecular mechanisms of macrophage polarization, their roles in health and disease, and the intervention with Chinese medicines to modulate the polarization of macrophages in tumor microenvironment (TME) for therapeutic purpose.-
dc.languageeng-
dc.publisherIntechOpen-
dc.relation.ispartofMacrophage Activation: Biology and Disease-
dc.subjecttumor microenvironment-
dc.subjecttumor-associated macrophage-
dc.subjectpolarization-
dc.subjectChinese medicine-
dc.titlePolarization of tumour-associated macrophages by Chinese medicine intervention: mechanisms and applications-
dc.typeBook_Chapter-
dc.identifier.emailTan, HYH: hyhtan@hku.hk-
dc.identifier.emailWang, N: ckwang@hku.hk-
dc.identifier.emailFeng, Y: yfeng@hku.hk-
dc.identifier.authorityWang, N=rp02075-
dc.identifier.authorityFeng, Y=rp00466-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.5772/intechopen.86484-
dc.identifier.hkuros320053-
dc.publisher.placeLondon-

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