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Book Chapter: The Underlying Mechanisms of Chinese Herbal Medicine-Induced Apoptotic Cell Death in Human Cancer

TitleThe Underlying Mechanisms of Chinese Herbal Medicine-Induced Apoptotic Cell Death in Human Cancer
Authors
Keywordscell apoptosis
Chinese herbal medicine
programmed cell death
intrinsic and extrinsic pathways
human cancer
Issue Date2020
PublisherIntechOpen
Citation
The Underlying Mechanisms of Chinese Herbal Medicine-Induced Apoptotic Cell Death in Human Cancer. In Gali-Muhtasib, H & Rahal, ON (Eds.), Programmed Cell Death. London: IntechOpen, 2020 How to Cite?
AbstractThe high incidence of cancer is a global burden. Cancer cells acquire immortality, which results in loss of control in cell proliferation and population expansion. Cancer cells undergo a series of genomic instability, leading to mutated amplification or deletion of certain genes that strictly control the cell fate. Programmed cell death is a mechanism of cell fate control that is aberrantly regulated in cancer cells. Apoptosis is the major form of programmed cell death regulated by both intrinsic and extrinsic pathways. Discovering effective and specific alternative solutions that can reprogram apoptosis in cancer cells is always a challenge. Chinese herbal medicine has captured increasing attention from both researchers and manufacturers, as evidenced by observable curative effects from previous clinical experience. Hence, to clarify and reinforce the understanding of the effect of Chinese medicine on cancer, in this chapter, we will retrospectively review the latest 5 years of literature and summarize the mode of action of Chinese herbal medicine on apoptotic cell death in cancer. Both Chinese medicine-induced intrinsic and extrinsic mechanisms of apoptosis will be discussed, and common compounds from Chinese medicine with druggable potential as novel apoptosis-inducing agents will be highlighted.
Persistent Identifierhttp://hdl.handle.net/10722/293840
ISBN

 

DC FieldValueLanguage
dc.contributor.authorChen, F-
dc.contributor.authorZhong, Z-
dc.contributor.authorTan, HYH-
dc.contributor.authorWang, N-
dc.contributor.authorFeng, Y-
dc.date.accessioned2020-11-23T08:22:33Z-
dc.date.available2020-11-23T08:22:33Z-
dc.date.issued2020-
dc.identifier.citationThe Underlying Mechanisms of Chinese Herbal Medicine-Induced Apoptotic Cell Death in Human Cancer. In Gali-Muhtasib, H & Rahal, ON (Eds.), Programmed Cell Death. London: IntechOpen, 2020-
dc.identifier.isbn9781789847482-
dc.identifier.urihttp://hdl.handle.net/10722/293840-
dc.description.abstractThe high incidence of cancer is a global burden. Cancer cells acquire immortality, which results in loss of control in cell proliferation and population expansion. Cancer cells undergo a series of genomic instability, leading to mutated amplification or deletion of certain genes that strictly control the cell fate. Programmed cell death is a mechanism of cell fate control that is aberrantly regulated in cancer cells. Apoptosis is the major form of programmed cell death regulated by both intrinsic and extrinsic pathways. Discovering effective and specific alternative solutions that can reprogram apoptosis in cancer cells is always a challenge. Chinese herbal medicine has captured increasing attention from both researchers and manufacturers, as evidenced by observable curative effects from previous clinical experience. Hence, to clarify and reinforce the understanding of the effect of Chinese medicine on cancer, in this chapter, we will retrospectively review the latest 5 years of literature and summarize the mode of action of Chinese herbal medicine on apoptotic cell death in cancer. Both Chinese medicine-induced intrinsic and extrinsic mechanisms of apoptosis will be discussed, and common compounds from Chinese medicine with druggable potential as novel apoptosis-inducing agents will be highlighted.-
dc.languageeng-
dc.publisherIntechOpen-
dc.relation.ispartofProgrammed Cell Death-
dc.subjectcell apoptosis-
dc.subjectChinese herbal medicine-
dc.subjectprogrammed cell death-
dc.subjectintrinsic and extrinsic pathways-
dc.subjecthuman cancer-
dc.titleThe Underlying Mechanisms of Chinese Herbal Medicine-Induced Apoptotic Cell Death in Human Cancer-
dc.typeBook_Chapter-
dc.identifier.emailZhong, Z: zfzhong@hku.hk-
dc.identifier.emailTan, HYH: hyhtan@hku.hk-
dc.identifier.emailWang, N: ckwang@hku.hk-
dc.identifier.emailFeng, Y: yfeng@hku.hk-
dc.identifier.authorityWang, N=rp02075-
dc.identifier.authorityFeng, Y=rp00466-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros320054-
dc.publisher.placeLondon-

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