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Article: Targeting Polyamine Metabolism for Control of Human Viral Diseases
Title | Targeting Polyamine Metabolism for Control of Human Viral Diseases |
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Authors | |
Keywords | polyamine metabolism virus infection diseases |
Issue Date | 2020 |
Publisher | Dove Medical Press Ltd. The Journal's web site is located at https://www.dovepress.com/infection-and-drug-resistance-journal |
Citation | Infection and Drug Resistance, 2020, v. 2020 n. 13, p. 4335-4346 How to Cite? |
Abstract | A virus is an infectious particle which generally contains nucleic acid genome (DNA or RNA inside a protein shell), except for human immunodeficiency virus (HIV). Viruses have to reproduce by infecting their host cells. Polyamines are ubiquitous compounds in mammalian cells and play key roles in various cellular processes. The metabolic pathways of polyamines have been well studied. Targeting these metabolic pathways can reduce infections caused by viruses. In the study, we systematically reviewed the association of polyamine metabolic pathways and viruses including coxsackievirus B3 (CVB3), enterovirus 71 (EV71), poliovirus (PV), Zika virus (ZKV), hepatitis C virus (HCV), hepatitis B virus (HBV), dengue virus (DENV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), Ebola virus (EBOV), marburgvirus (MARV), chikungunya virus (CHIKV), sindbis virus (SINV), Semliki Forest virus (SFV), Epstein–Barr virus (EBV), herpes simplex virus 1 (HSV), human cytomegalovirus (HCMV), vesicular stomatitis virus (VSV), Rabies virus (RABV), Rift Valley fever virus (RVFV), La Crosse virus (LACV), human immunodeficiency virus (HIV), Middle East respiratory syndrome virus (MERS-CoV), and coronavirus disease 2019 (SARS-CoV-2). This review revealed that targeting polyamine metabolic pathways may be a potential approach to control human viral infection. |
Persistent Identifier | http://hdl.handle.net/10722/295213 |
ISSN | 2021 Impact Factor: 4.177 2020 SCImago Journal Rankings: 1.033 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Huang, M | - |
dc.contributor.author | Zhang, W | - |
dc.contributor.author | Chen, H | - |
dc.contributor.author | Zeng, J | - |
dc.date.accessioned | 2021-01-11T13:56:56Z | - |
dc.date.available | 2021-01-11T13:56:56Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Infection and Drug Resistance, 2020, v. 2020 n. 13, p. 4335-4346 | - |
dc.identifier.issn | 1178-6973 | - |
dc.identifier.uri | http://hdl.handle.net/10722/295213 | - |
dc.description.abstract | A virus is an infectious particle which generally contains nucleic acid genome (DNA or RNA inside a protein shell), except for human immunodeficiency virus (HIV). Viruses have to reproduce by infecting their host cells. Polyamines are ubiquitous compounds in mammalian cells and play key roles in various cellular processes. The metabolic pathways of polyamines have been well studied. Targeting these metabolic pathways can reduce infections caused by viruses. In the study, we systematically reviewed the association of polyamine metabolic pathways and viruses including coxsackievirus B3 (CVB3), enterovirus 71 (EV71), poliovirus (PV), Zika virus (ZKV), hepatitis C virus (HCV), hepatitis B virus (HBV), dengue virus (DENV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), Ebola virus (EBOV), marburgvirus (MARV), chikungunya virus (CHIKV), sindbis virus (SINV), Semliki Forest virus (SFV), Epstein–Barr virus (EBV), herpes simplex virus 1 (HSV), human cytomegalovirus (HCMV), vesicular stomatitis virus (VSV), Rabies virus (RABV), Rift Valley fever virus (RVFV), La Crosse virus (LACV), human immunodeficiency virus (HIV), Middle East respiratory syndrome virus (MERS-CoV), and coronavirus disease 2019 (SARS-CoV-2). This review revealed that targeting polyamine metabolic pathways may be a potential approach to control human viral infection. | - |
dc.language | eng | - |
dc.publisher | Dove Medical Press Ltd. The Journal's web site is located at https://www.dovepress.com/infection-and-drug-resistance-journal | - |
dc.relation.ispartof | Infection and Drug Resistance | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | polyamine metabolism | - |
dc.subject | virus | - |
dc.subject | infection | - |
dc.subject | diseases | - |
dc.title | Targeting Polyamine Metabolism for Control of Human Viral Diseases | - |
dc.type | Article | - |
dc.identifier.email | Chen, H: haiyong@hku.hk | - |
dc.identifier.authority | Chen, H=rp01923 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.2147/IDR.S262024 | - |
dc.identifier.pmid | 33293837 | - |
dc.identifier.pmcid | PMC7718961 | - |
dc.identifier.scopus | eid_2-s2.0-85097824728 | - |
dc.identifier.hkuros | 320816 | - |
dc.identifier.volume | 2020 | - |
dc.identifier.issue | 13 | - |
dc.identifier.spage | 4335 | - |
dc.identifier.epage | 4346 | - |
dc.identifier.isi | WOS:000597248500002 | - |
dc.publisher.place | United Kingdom | - |